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The map label for this gene is obgE

Identifier: 220905509

GI number: 220905509

Start: 2708882

End: 2709982

Strand: Reverse

Name: obgE

Synonym: Ddes_2248

Alternate gene names: 220905509

Gene position: 2709982-2708882 (Counterclockwise)

Preceding gene: 220905510

Following gene: 220905508

Centisome position: 94.31

GC content: 61.04

Gene sequence:

>1101_bases
ATGAGATTTGTGGATGAAGCCAGAATTCAGGTGCGTGCCGGCAAAGGCGGGCACGGCTGCCTGTCCTTCCGGCGCGAAAA
ATTTGTACCCCGAGGCGGCCCGGACGGCGGCAACGGGGGGGATGGCGGTTCTGTGTACCTCAGGGCAGATAACCGGCTGC
TCTCGCTGTACGACTTTCGCCTCAAGCGCCTGTACGAGGCACAGAACGGCCGCCCCGGCGAGGGCAGCCAGTGCGATGGC
CGCAAGGGCGAAAATCTGGTTCTGAATCTGCCCGTGGGAACGCTGGTGTACGCGGAAGGTCCCGAAGGTGAAGTGCTGGT
GGCCGACCTGAGCGAGCCGGATGCGGAAGTGCTGGTAGCCAGCGGCGGCCGCGGCGGCAAGGGGAATGAGCATTTCAAGT
CTTCGACCATGCGCGCGCCGCGGTTTTCGCAACCCGGCGAACCCGGAGAGGAATTCAATCTGCGGCTTGAGCTGAAAATT
CTGGCGGACGCCGGTCTGATAGGCTTGCCCAACGCCGGAAAATCCACATTCATTTCGCAGGTGTCGGCCGCGCGGCCCAA
GATTGCCGCGTATCCCTTCACCACGCTTACCCCCAATCTGGGGGTGATGATTGATGAGGTCGACCCGGACAGGCGCATGG
TCATTGCCGACATCCCGGGTCTGATCGAAGGGGCGCACGAAGGGCAGGGGCTTGGCCTGCGTTTTCTCAAGCATGTGGAG
CGCACACGTTTTCTCGTGCACATTCTCAGCATCGAGGATGTGGGCGATGAAGACCCCTGGGCGGGCTTCAGCCTGGTCAA
TGAAGAGCTGCGCCGGTTTGACGCGGAGCTTGGCGAGCGCAGGCAGATCGAGGTGGTGAACAAAATCGACCTTGTAAGCC
CTGAAAGGCTGGAAGCCCTGAAAGAGCGGGCCAGAGCCGACGGGCGCGAGGTTTACTTCATTTCTGCCCGCGATGACCTG
GGTCTTGAGCCTCTGGTGCAGGAGCTTTGGCAGGTTTGCGAGAGCACCGCACGCAACGAGCCGATTGTGCGTCTGGAAGG
CCTCACCGATGTGGAGGAAGAGGAATTTCCCGAAATTGAAGTCATCTATACCCGCGAATAG

Upstream 100 bases:

>100_bases
CGCAAGGCTTCTTCCCTTTCGGTGTTTGTGTGCCGTGACCCTGCCGGCCGCAACATGCCGCTGAAAAACAAGCCCGTAAG
CATCGGGCAGAGGATATTGC

Downstream 100 bases:

>100_bases
CGGGATGTGGAGCGGATATGAGCAGGCAGCGCCCTCATGGCACGGCGTCCGGAGCCGGACGGCCGGAGCAGTGCGGCACG
TGTGGCTCTGAAGAAGAGCG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRFVDEARIQVRAGKGGHGCLSFRREKFVPRGGPDGGNGGDGGSVYLRADNRLLSLYDFRLKRLYEAQNGRPGEGSQCDG
RKGENLVLNLPVGTLVYAEGPEGEVLVADLSEPDAEVLVASGGRGGKGNEHFKSSTMRAPRFSQPGEPGEEFNLRLELKI
LADAGLIGLPNAGKSTFISQVSAARPKIAAYPFTTLTPNLGVMIDEVDPDRRMVIADIPGLIEGAHEGQGLGLRFLKHVE
RTRFLVHILSIEDVGDEDPWAGFSLVNEELRRFDAELGERRQIEVVNKIDLVSPERLEALKERARADGREVYFISARDDL
GLEPLVQELWQVCESTARNEPIVRLEGLTDVEEEEFPEIEVIYTRE

Sequences:

>Translated_366_residues
MRFVDEARIQVRAGKGGHGCLSFRREKFVPRGGPDGGNGGDGGSVYLRADNRLLSLYDFRLKRLYEAQNGRPGEGSQCDG
RKGENLVLNLPVGTLVYAEGPEGEVLVADLSEPDAEVLVASGGRGGKGNEHFKSSTMRAPRFSQPGEPGEEFNLRLELKI
LADAGLIGLPNAGKSTFISQVSAARPKIAAYPFTTLTPNLGVMIDEVDPDRRMVIADIPGLIEGAHEGQGLGLRFLKHVE
RTRFLVHILSIEDVGDEDPWAGFSLVNEELRRFDAELGERRQIEVVNKIDLVSPERLEALKERARADGREVYFISARDDL
GLEPLVQELWQVCESTARNEPIVRLEGLTDVEEEEFPEIEVIYTRE
>Mature_366_residues
MRFVDEARIQVRAGKGGHGCLSFRREKFVPRGGPDGGNGGDGGSVYLRADNRLLSLYDFRLKRLYEAQNGRPGEGSQCDG
RKGENLVLNLPVGTLVYAEGPEGEVLVADLSEPDAEVLVASGGRGGKGNEHFKSSTMRAPRFSQPGEPGEEFNLRLELKI
LADAGLIGLPNAGKSTFISQVSAARPKIAAYPFTTLTPNLGVMIDEVDPDRRMVIADIPGLIEGAHEGQGLGLRFLKHVE
RTRFLVHILSIEDVGDEDPWAGFSLVNEELRRFDAELGERRQIEVVNKIDLVSPERLEALKERARADGREVYFISARDDL
GLEPLVQELWQVCESTARNEPIVRLEGLTDVEEEEFPEIEVIYTRE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=338, Percent_Identity=42.0118343195266, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI111955139, Length=298, Percent_Identity=35.9060402684564, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI111955063, Length=130, Percent_Identity=41.5384615384615, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI58761500, Length=134, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=359, Percent_Identity=47.075208913649, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=38.2978723404255, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=306, Percent_Identity=29.7385620915033, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=220, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=184, Percent_Identity=41.8478260869565, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI20129375, Length=289, Percent_Identity=40.1384083044983, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24585318, Length=297, Percent_Identity=37.7104377104377, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24640873, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640877, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640875, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_DESDA (B8J4L3)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480821.1
- GeneID:   7285965
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2248
- HOGENOM:   HBG716038
- ProtClustDB:   PRK12299
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 40419; Mature: 40419

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVDEARIQVRAGKGGHGCLSFRREKFVPRGGPDGGNGGDGGSVYLRADNRLLSLYDFR
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHH
LKRLYEAQNGRPGEGSQCDGRKGENLVLNLPVGTLVYAEGPEGEVLVADLSEPDAEVLVA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCEEEEE
SGGRGGKGNEHFKSSTMRAPRFSQPGEPGEEFNLRLELKILADAGLIGLPNAGKSTFISQ
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHH
VSAARPKIAAYPFTTLTPNLGVMIDEVDPDRRMVIADIPGLIEGAHEGQGLGLRFLKHVE
HHHCCCCEEECCCCCCCCCCCEEEECCCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHH
RTRFLVHILSIEDVGDEDPWAGFSLVNEELRRFDAELGERRQIEVVNKIDLVSPERLEAL
HHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHH
KERARADGREVYFISARDDLGLEPLVQELWQVCESTARNEPIVRLEGLTDVEEEEFPEIE
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCEE
VIYTRE
EEEECC
>Mature Secondary Structure
MRFVDEARIQVRAGKGGHGCLSFRREKFVPRGGPDGGNGGDGGSVYLRADNRLLSLYDFR
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHH
LKRLYEAQNGRPGEGSQCDGRKGENLVLNLPVGTLVYAEGPEGEVLVADLSEPDAEVLVA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCEEEEE
SGGRGGKGNEHFKSSTMRAPRFSQPGEPGEEFNLRLELKILADAGLIGLPNAGKSTFISQ
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHH
VSAARPKIAAYPFTTLTPNLGVMIDEVDPDRRMVIADIPGLIEGAHEGQGLGLRFLKHVE
HHHCCCCEEECCCCCCCCCCCEEEECCCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHH
RTRFLVHILSIEDVGDEDPWAGFSLVNEELRRFDAELGERRQIEVVNKIDLVSPERLEAL
HHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHH
KERARADGREVYFISARDDLGLEPLVQELWQVCESTARNEPIVRLEGLTDVEEEEFPEIE
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCEE
VIYTRE
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA