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The map label for this gene is ttcA [H]

Identifier: 220905422

GI number: 220905422

Start: 2603874

End: 2604668

Strand: Reverse

Name: ttcA [H]

Synonym: Ddes_2160

Alternate gene names: 220905422

Gene position: 2604668-2603874 (Counterclockwise)

Preceding gene: 220905425

Following gene: 220905421

Centisome position: 90.65

GC content: 58.74

Gene sequence:

>795_bases
ATGAGCAGAGAAAAACGGTCTTTCGCGCAGGAAGTATGCGTGAAAAGCGCGGGCAAGGCCATGCAGATGACAGGCATGCT
CTGGCCCGGCTGCCGAGTGGGAGTGGCGGCCTCCGGCGGGGTGGACAGCTTTGTATTGCTGAAAACGCTTAAAATACGCC
AGGGAATCGTACCTTTTCGCTTTGAAATCATGGCCCTGCACCTTAATCCCGGCTTTGACGGCCAGAGTCACGCGGCGCTT
TTGCCCTGGCTGGCGGCGCACGGCATTCCTGCTCATGTTGAGGTTACAAGCCACGGGCCTGACGCCCATTCAGAAAAAAA
CCTGCGCCGCTCGGCCTGTTTCCGCTGTGCCTGGCTGCGTCGCAAAAGACTGTTCGAGCTTTGCTCGCAGTACGGGCTTA
CCCATCTTGCCCTGGGACATAATGCCGAGGATCTGGTGGAAACGTTTTTCATGAACATCTGCCGCAACGGGCGTGTGGAC
GGCATGAGCATGAACGAGCCTTTTTTTGACGGCAAGTTACGGCTTATCCGCCCGCTCATGCTGGTGGAGAAAAAATACAT
ACGTCAGGCGGCGCGGCAATGGGGCCTGCCCATATGGGCCAACGCCTGCCCCTCAGCCGGAAAGACAGCCAGAAGCGACA
TGGCCCAGACCCTTGAACATCTTTATGCCATCACAAAAGACGGCCGTCGCTGTGTGCTCAACGGCCTGACCCGCTGGCAG
CTCGATAAAAGCAGCGCGGCCGCGCGTGAGCGCGCGCAGGCAGACATGCGGGAAGGTGTGCAGGATGACGGCTGA

Upstream 100 bases:

>100_bases
TTGCCTGCTGAAATAAGATATGATATAGGCCGCCTCTGTACCTGTCAAGAGCCGGGAAAGCGGCCCGCAGCATAGACTAT
TGTTAAGGAGATTGCCAGCC

Downstream 100 bases:

>100_bases
GGGTGTGCGCGCCAATCGCATTGACAGGGCCGCCACAGCCCCCTAAAGTTGCTCCGCATGCTTTTCGGCAAATACCATAT
AGTCATATTCAAAGAGGGCC

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSREKRSFAQEVCVKSAGKAMQMTGMLWPGCRVGVAASGGVDSFVLLKTLKIRQGIVPFRFEIMALHLNPGFDGQSHAAL
LPWLAAHGIPAHVEVTSHGPDAHSEKNLRRSACFRCAWLRRKRLFELCSQYGLTHLALGHNAEDLVETFFMNICRNGRVD
GMSMNEPFFDGKLRLIRPLMLVEKKYIRQAARQWGLPIWANACPSAGKTARSDMAQTLEHLYAITKDGRRCVLNGLTRWQ
LDKSSAAARERAQADMREGVQDDG

Sequences:

>Translated_264_residues
MSREKRSFAQEVCVKSAGKAMQMTGMLWPGCRVGVAASGGVDSFVLLKTLKIRQGIVPFRFEIMALHLNPGFDGQSHAAL
LPWLAAHGIPAHVEVTSHGPDAHSEKNLRRSACFRCAWLRRKRLFELCSQYGLTHLALGHNAEDLVETFFMNICRNGRVD
GMSMNEPFFDGKLRLIRPLMLVEKKYIRQAARQWGLPIWANACPSAGKTARSDMAQTLEHLYAITKDGRRCVLNGLTRWQ
LDKSSAAARERAQADMREGVQDDG
>Mature_263_residues
SREKRSFAQEVCVKSAGKAMQMTGMLWPGCRVGVAASGGVDSFVLLKTLKIRQGIVPFRFEIMALHLNPGFDGQSHAALL
PWLAAHGIPAHVEVTSHGPDAHSEKNLRRSACFRCAWLRRKRLFELCSQYGLTHLALGHNAEDLVETFFMNICRNGRVDG
MSMNEPFFDGKLRLIRPLMLVEKKYIRQAARQWGLPIWANACPSAGKTARSDMAQTLEHLYAITKDGRRCVLNGLTRWQL
DKSSAAARERAQADMREGVQDDG

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=206, Percent_Identity=30.0970873786408, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=246, Percent_Identity=29.2682926829268, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 29509; Mature: 29377

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREKRSFAQEVCVKSAGKAMQMTGMLWPGCRVGVAASGGVDSFVLLKTLKIRQGIVPFR
CCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
FEIMALHLNPGFDGQSHAALLPWLAAHGIPAHVEVTSHGPDAHSEKNLRRSACFRCAWLR
EEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
RKRLFELCSQYGLTHLALGHNAEDLVETFFMNICRNGRVDGMSMNEPFFDGKLRLIRPLM
HHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LVEKKYIRQAARQWGLPIWANACPSAGKTARSDMAQTLEHLYAITKDGRRCVLNGLTRWQ
HHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHC
LDKSSAAARERAQADMREGVQDDG
CCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SREKRSFAQEVCVKSAGKAMQMTGMLWPGCRVGVAASGGVDSFVLLKTLKIRQGIVPFR
CCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
FEIMALHLNPGFDGQSHAALLPWLAAHGIPAHVEVTSHGPDAHSEKNLRRSACFRCAWLR
EEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
RKRLFELCSQYGLTHLALGHNAEDLVETFFMNICRNGRVDGMSMNEPFFDGKLRLIRPLM
HHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LVEKKYIRQAARQWGLPIWANACPSAGKTARSDMAQTLEHLYAITKDGRRCVLNGLTRWQ
HHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHC
LDKSSAAARERAQADMREGVQDDG
CCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA