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The map label for this gene is yiaY [H]

Identifier: 220905205

GI number: 220905205

Start: 2339290

End: 2340489

Strand: Reverse

Name: yiaY [H]

Synonym: Ddes_1943

Alternate gene names: 220905205

Gene position: 2340489-2339290 (Counterclockwise)

Preceding gene: 220905206

Following gene: 220905192

Centisome position: 81.45

GC content: 56.75

Gene sequence:

>1200_bases
ATGAGTACGGAGCTTAAGAGCATGCATATGGGGCAGGTTACCTCCTTCTTCATTCCCAATGTTACTCTTGTGGGCGAAGG
GTGTTCCAAGGAAATTCCCGCCCGTCTCAAAAATATCGGCGGCGGCAAACCGCTGATCGTTACGGACCAGGGCATCGTCA
AGGCCGGCATTCTCAAACAGATTACCGGTATTCTTGATGCTGCCAAAATGCAGTACGCCATTTACGACCAGACCGTGCCC
AACCCCACTGACCATAACGTGGACGCGGCCTTCGAGATGTACAAGAAAGAAAAGTGCGACAGCCTTATCACCCTTGGCGG
CGGCAGTTCGCATGACTGCGGCAAGGGCGTGGGCTTTCTTGCCGGCAACGGCGGAAAAATTCATGATTATGAAGGCGTGG
ATAAATCCACCAAGCCCTTCCCGCCTTATGTGGCCGTCAATACCACGGCCGGTACCGCCTCTGAAATGACCCGCTTCTGC
ATCATTACCGACACCTCGCGCAAAGTGAAAATGGCTATTGTTGACTGGCGCTGTACGCCCGGTGTGGCCATTGACGACCC
CCTGCTCATGATGGGCATGCCCCCGGCGCTTACCGCCGCCACGGGCATGGACGCCCTGACCCACGCTGTAGAGGCGTATG
TGTCCACGGCAGCCACTCCTATGACCGATGCCTGCGCTGAAAAGGCTATGGAATTTATCAACCGCTACCTGCGTCGCGCT
GTGGCCAACGGTCAGGACAAAGAAGCCCGCGAAGGCATGTGCTATGCCCAGTATCTGGCTGGTATGGCCTTCAACAACGC
GAGCCTCGGTCATGTGCATGCCATGGCGCACCAGCTGGGCGGCTTTTATGACCTGCCGCATGGCGAATGCAATGCCATTC
TGCTGCCCCACGTTTGCGAGTATAACCGCATGGCGACCCGCCGCCGCTTCGGCCGCATTGCCCGCCTGCTTGGTGAAATC
ACCGACGGGCTGAGCGCCGACGAAGCTTCTAAAAAGGCCATTGCCGCCATCAATACCCTGTCTTCTGATGTGGGCATTCC
CGAGGGACTCAAGGCTCTTGGCAAAAAGTATGGCAAGGATGTGAAAGAAGCGGACATTCCCACTATGACCGCCAATGCCC
AGAAAGACGCCTGTGGCCTTACCAATCCTCGCACCATGACTGATGCCGCTGTGGCTGCCATTTACAAGGCTGCCATGTAG

Upstream 100 bases:

>100_bases
TTGATGCTGTACTCTTTTTTGCAAGGTTATTTCCTTATCACTGCGGTACAATAGTGGTACATGTCGCGCGATTGTGTCCG
CATAACGCTAGGAGTCGCAT

Downstream 100 bases:

>100_bases
GTTTTTGACAGTGCCTTGCGGTCCCGCCCTGGCGGGACCGCAGAAAACACAAAAGGGCCGCCCGGCATATGGGCGGCCCT
TTTGTGTGGCAATATCATGC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSTELKSMHMGQVTSFFIPNVTLVGEGCSKEIPARLKNIGGGKPLIVTDQGIVKAGILKQITGILDAAKMQYAIYDQTVP
NPTDHNVDAAFEMYKKEKCDSLITLGGGSSHDCGKGVGFLAGNGGKIHDYEGVDKSTKPFPPYVAVNTTAGTASEMTRFC
IITDTSRKVKMAIVDWRCTPGVAIDDPLLMMGMPPALTAATGMDALTHAVEAYVSTAATPMTDACAEKAMEFINRYLRRA
VANGQDKEAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVCEYNRMATRRRFGRIARLLGEI
TDGLSADEASKKAIAAINTLSSDVGIPEGLKALGKKYGKDVKEADIPTMTANAQKDACGLTNPRTMTDAAVAAIYKAAM

Sequences:

>Translated_399_residues
MSTELKSMHMGQVTSFFIPNVTLVGEGCSKEIPARLKNIGGGKPLIVTDQGIVKAGILKQITGILDAAKMQYAIYDQTVP
NPTDHNVDAAFEMYKKEKCDSLITLGGGSSHDCGKGVGFLAGNGGKIHDYEGVDKSTKPFPPYVAVNTTAGTASEMTRFC
IITDTSRKVKMAIVDWRCTPGVAIDDPLLMMGMPPALTAATGMDALTHAVEAYVSTAATPMTDACAEKAMEFINRYLRRA
VANGQDKEAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVCEYNRMATRRRFGRIARLLGEI
TDGLSADEASKKAIAAINTLSSDVGIPEGLKALGKKYGKDVKEADIPTMTANAQKDACGLTNPRTMTDAAVAAIYKAAM
>Mature_398_residues
STELKSMHMGQVTSFFIPNVTLVGEGCSKEIPARLKNIGGGKPLIVTDQGIVKAGILKQITGILDAAKMQYAIYDQTVPN
PTDHNVDAAFEMYKKEKCDSLITLGGGSSHDCGKGVGFLAGNGGKIHDYEGVDKSTKPFPPYVAVNTTAGTASEMTRFCI
ITDTSRKVKMAIVDWRCTPGVAIDDPLLMMGMPPALTAATGMDALTHAVEAYVSTAATPMTDACAEKAMEFINRYLRRAV
ANGQDKEAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVCEYNRMATRRRFGRIARLLGEIT
DGLSADEASKKAIAAINTLSSDVGIPEGLKALGKKYGKDVKEADIPTMTANAQKDACGLTNPRTMTDAAVAAIYKAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=415, Percent_Identity=26.9879518072289, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI48994951, Length=386, Percent_Identity=52.8497409326425, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1789163, Length=376, Percent_Identity=42.5531914893617, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI87082107, Length=396, Percent_Identity=35.6060606060606, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1787493, Length=377, Percent_Identity=34.2175066312997, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789386, Length=339, Percent_Identity=27.1386430678466, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=416, Percent_Identity=26.2019230769231, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=391, Percent_Identity=50.1278772378517, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24657991, Length=416, Percent_Identity=26.2019230769231, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 42569; Mature: 42438

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTELKSMHMGQVTSFFIPNVTLVGEGCSKEIPARLKNIGGGKPLIVTDQGIVKAGILKQ
CCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHH
ITGILDAAKMQYAIYDQTVPNPTDHNVDAAFEMYKKEKCDSLITLGGGSSHDCGKGVGFL
HHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEE
AGNGGKIHDYEGVDKSTKPFPPYVAVNTTAGTASEMTRFCIITDTSRKVKMAIVDWRCTP
ECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEECCC
GVAIDDPLLMMGMPPALTAATGMDALTHAVEAYVSTAATPMTDACAEKAMEFINRYLRRA
CCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VANGQDKEAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVCE
HCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEECCCCCCCCEEECCHHHH
YNRMATRRRFGRIARLLGEITDGLSADEASKKAIAAINTLSSDVGIPEGLKALGKKYGKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
VKEADIPTMTANAQKDACGLTNPRTMTDAAVAAIYKAAM
CHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STELKSMHMGQVTSFFIPNVTLVGEGCSKEIPARLKNIGGGKPLIVTDQGIVKAGILKQ
CCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHH
ITGILDAAKMQYAIYDQTVPNPTDHNVDAAFEMYKKEKCDSLITLGGGSSHDCGKGVGFL
HHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEE
AGNGGKIHDYEGVDKSTKPFPPYVAVNTTAGTASEMTRFCIITDTSRKVKMAIVDWRCTP
ECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEECCC
GVAIDDPLLMMGMPPALTAATGMDALTHAVEAYVSTAATPMTDACAEKAMEFINRYLRRA
CCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VANGQDKEAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVCE
HCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEECCCCCCCCEEECCHHHH
YNRMATRRRFGRIARLLGEITDGLSADEASKKAIAAINTLSSDVGIPEGLKALGKKYGKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
VKEADIPTMTANAQKDACGLTNPRTMTDAAVAAIYKAAM
CHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]