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The map label for this gene is hldD [H]

Identifier: 220905182

GI number: 220905182

Start: 2314176

End: 2315147

Strand: Reverse

Name: hldD [H]

Synonym: Ddes_1920

Alternate gene names: 220905182

Gene position: 2315147-2314176 (Counterclockwise)

Preceding gene: 220905190

Following gene: 220905177

Centisome position: 80.57

GC content: 56.69

Gene sequence:

>972_bases
TTGTACGTGATTACCGGTGGAGCGGGTTTTTTGGGCAGCGCTCTTTTATGGCAGCTTAACTGCATGAACATTGACGATAT
CGTGATTGTGGACAACCTGGCACGGAGCGATAAATGGCGTAATCTCGTCAAGCGCCGCTACGTGGACTATCTGCACAGGG
ACCAGTTTTACGATCTCATGCAGCGCGATGCCCTGCCCTGGAAGGTCAGCGGCGTGGTGCATCTCGGAGCCTGTTCGTCC
ACCACGGAAAAGGACGCGGATTTTCTGATGGAAAACAATTTCCATTACAGTCGCGACCTGTGCCGTTACACGCTGGACAA
GGGGGGCCGCTTCATCAATGCCAGCTCCGCCGCGACCTATGGCGACGGTTCGCTGGGATTCAGCGATGACGAGCAGCTTG
TGCCGCGCCTGCGGCCTTTGAACATGTACGGCTACTCCAAACAGCTTTTTGACCTATGGCTGCTACGCGAGGGCTTGCAG
GCCGAAACGGCCAGCCTGAAATTTTTCAATGTTTACGGTCCCAACGAATATCACAAGGGCGATATGCAGAGTGTGGCTGC
CAAGGCCCACCGGCAGATAGGCCAGGAAGGTTTGCTGCGGCTCTTCAGGTCCGACCGCCCGGATGTGGCGGACGGGGAAC
AGAAGCGCGATTTTGTTTACGTCAAGGACTGCACTGCCCTGATGGCCTGGCTGCTGGAACGCAACGATGTTTGCGGTATC
CACAACGTGGGTACAGGAACCGCGCGCAGCTTTAACGATCTGGCGCAGGCCGTGTTTGCGGCCCTGAACCGGCCCTGCCA
TATAGAGTATGTGGATATGCCCGACAGCCTGCGGGGGCGCTACCAGCACTACACACAGGCAGACATGGCCTGGCTCGGGC
AGGTAGATTGCCCGCTTGCATTTACACCGCTTGAAGAAGGCGTGGCAGACTATGTGAAGGGCTATCTGGAAAAAGAAGAC
CCCTATCTGTAG

Upstream 100 bases:

>100_bases
GTGTCCAGAGGAAGGCGCGCGAACAGGATAAACACGTGGCGGGCCTTGCGGTTGCGGCCCGCACTGGCTACCATGCGTAA
AGATGTAATGGAGGTGTCCA

Downstream 100 bases:

>100_bases
GGACCGGGTTTGCAGGCGCGGATTTTCTCCGGCTGCGGGTTGTGCCGTACCTGTATTTACGACCGGGACTGCGCCGCCGG
GGCAACTGGCAAAGCCTCCC

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MYVITGGAGFLGSALLWQLNCMNIDDIVIVDNLARSDKWRNLVKRRYVDYLHRDQFYDLMQRDALPWKVSGVVHLGACSS
TTEKDADFLMENNFHYSRDLCRYTLDKGGRFINASSAATYGDGSLGFSDDEQLVPRLRPLNMYGYSKQLFDLWLLREGLQ
AETASLKFFNVYGPNEYHKGDMQSVAAKAHRQIGQEGLLRLFRSDRPDVADGEQKRDFVYVKDCTALMAWLLERNDVCGI
HNVGTGTARSFNDLAQAVFAALNRPCHIEYVDMPDSLRGRYQHYTQADMAWLGQVDCPLAFTPLEEGVADYVKGYLEKED
PYL

Sequences:

>Translated_323_residues
MYVITGGAGFLGSALLWQLNCMNIDDIVIVDNLARSDKWRNLVKRRYVDYLHRDQFYDLMQRDALPWKVSGVVHLGACSS
TTEKDADFLMENNFHYSRDLCRYTLDKGGRFINASSAATYGDGSLGFSDDEQLVPRLRPLNMYGYSKQLFDLWLLREGLQ
AETASLKFFNVYGPNEYHKGDMQSVAAKAHRQIGQEGLLRLFRSDRPDVADGEQKRDFVYVKDCTALMAWLLERNDVCGI
HNVGTGTARSFNDLAQAVFAALNRPCHIEYVDMPDSLRGRYQHYTQADMAWLGQVDCPLAFTPLEEGVADYVKGYLEKED
PYL
>Mature_323_residues
MYVITGGAGFLGSALLWQLNCMNIDDIVIVDNLARSDKWRNLVKRRYVDYLHRDQFYDLMQRDALPWKVSGVVHLGACSS
TTEKDADFLMENNFHYSRDLCRYTLDKGGRFINASSAATYGDGSLGFSDDEQLVPRLRPLNMYGYSKQLFDLWLLREGLQ
AETASLKFFNVYGPNEYHKGDMQSVAAKAHRQIGQEGLLRLFRSDRPDVADGEQKRDFVYVKDCTALMAWLLERNDVCGI
HNVGTGTARSFNDLAQAVFAALNRPCHIEYVDMPDSLRGRYQHYTQADMAWLGQVDCPLAFTPLEEGVADYVKGYLEKED
PYL

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=317, Percent_Identity=40.6940063091483, Blast_Score=219, Evalue=1e-58,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36812; Mature: 36812

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVITGGAGFLGSALLWQLNCMNIDDIVIVDNLARSDKWRNLVKRRYVDYLHRDQFYDLM
CEEEECCCHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRDALPWKVSGVVHLGACSSTTEKDADFLMENNFHYSRDLCRYTLDKGGRFINASSAATY
HHCCCCEEECCEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCC
GDGSLGFSDDEQLVPRLRPLNMYGYSKQLFDLWLLREGLQAETASLKFFNVYGPNEYHKG
CCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
DMQSVAAKAHRQIGQEGLLRLFRSDRPDVADGEQKRDFVYVKDCTALMAWLLERNDVCGI
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
HNVGTGTARSFNDLAQAVFAALNRPCHIEYVDMPDSLRGRYQHYTQADMAWLGQVDCPLA
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEE
FTPLEEGVADYVKGYLEKEDPYL
ECCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYVITGGAGFLGSALLWQLNCMNIDDIVIVDNLARSDKWRNLVKRRYVDYLHRDQFYDLM
CEEEECCCHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRDALPWKVSGVVHLGACSSTTEKDADFLMENNFHYSRDLCRYTLDKGGRFINASSAATY
HHCCCCEEECCEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCC
GDGSLGFSDDEQLVPRLRPLNMYGYSKQLFDLWLLREGLQAETASLKFFNVYGPNEYHKG
CCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
DMQSVAAKAHRQIGQEGLLRLFRSDRPDVADGEQKRDFVYVKDCTALMAWLLERNDVCGI
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
HNVGTGTARSFNDLAQAVFAALNRPCHIEYVDMPDSLRGRYQHYTQADMAWLGQVDCPLA
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEE
FTPLEEGVADYVKGYLEKEDPYL
ECCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA