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The map label for this gene is ziaA [H]

Identifier: 220904534

GI number: 220904534

Start: 1493313

End: 1495403

Strand: Direct

Name: ziaA [H]

Synonym: Ddes_1265

Alternate gene names: 220904534

Gene position: 1493313-1495403 (Clockwise)

Preceding gene: 220904533

Following gene: 220904539

Centisome position: 51.97

GC content: 57.87

Gene sequence:

>2091_bases
ATGAGCCATTGCTCCGCAAAAAACCATAACCACAGCAATGGGCACGCTTGTGCCTGCAATTCGACTACCGGCACACTTGC
CCCCATACCCACTCCGGATACTCAGAACTGCGCCAGCTCATCCGCCGGACCTACCGCGCCCTGCGGGACGACAGAAGAGG
AAGAGCAACACGGTTGCGGCTGCAGTTCGTGCGGCTGCCATGATCACTCGCATGAGCACGGCTCTGGTGATGAACGCCGC
GAACTTGTCATTATGGGTATATCAGCAGTGCTTTTCGGCATTGGAATGGTGGCCGACGAGGCCATGGCGCGGTATGTTCC
CAACTGGCTGGTCATTGCCGTATTTTATGCCCTGCCGTATTTTCTTTGCGGCTATGACGTGTTGCACCTTGGCTTGCGCA
GCATTGTTAAAAAAGACTTTTTTAATGAGTTTACCCTGATGGGGGGAGCAACCATTGCGGCCATCGCTCTTGGACAATTG
CCTGAAGCCGTAGGGGTAATGCTCTTCTACCGCATCGGCGAGTTTGTGCAGGAGCGGGCGGCGGGGCATTCGCGTCGTTC
GGTCAAGGCGCTTCTGGCGGCACGCCCGAGCACCGCCCATGAAATGCTTGATGACGGCACTACGCGGGACGTCCAGCCAG
AAGATCTTGGCCCCGGCAGCCACATCCTTGTACGCCCCGGCGAAAAAATCCCGCTTGACGGTACCGTGCTTGAAGGCAAC
TCGCAAGTGGATACCTCGCCTCTCACGGGTGAATCCGTGCCGCTTCTTCTGAAGCCCGGCAGTCGCGCTCTTGCAGGCAC
TATCAATCTTAATGGTGCGATCCGCATGGAAGTGACTGCGCCTTTTGCCGAGTCATCCATCGCGCGAATTCTGGAAATGG
TGGAAAACGCAGCTGCGCGTAAAGCTCCTACCGAACGCTTCATCACCCGCATGGCTCGCTGGTATACCCCTGCCGTAACC
GGCCTTGCCCTGCTTGTAGCTGTGGTGCCGCCCATTATAGGGCTGGGTGATTTTTCACAGTGGCTTTACCGTGCTCTGGT
GCTTCTGGTGATTTCCTGCCCCTGCGCCCTGCTCATATCCATCCCGCTCGGCTACTTTGGCGGCATAGGAGCAGCATCCC
GCCGGGGGATACTCATCAAGGGCGGCGCTGTGCTGGACAAGCTGCGTGATATCCGCGTGGCAGCTCTGGACAAAACCGGC
ACTCTTACCGAAGGAGTATTTGAAGTCAACGCCGTACTGCCGGCCCTTGGAACGGACTCCACTGAGCTGTTGCAGGCTGC
TGCCCTGGCCGAAAGCCGTTCGAACCACCCCATTGCCCGCTCTGTAATCAGAGCTGCGGAACATGCCAATATCGTTACCG
ATGATTCGACCATCACGGCGATGCGTGAAATTCCCGGTAAAGGTGTTGAGGCAACCACATACGACACTACCCTTCTGGCC
GGAAATGCCGCCCTCATGGAAGCCAACGGCATTGCACCACAAGCAGTAGACATGCCCGGCAGTATTGTTCAGGTGGCTCG
CAACGGCCGCCTGCTTGGCGCACTCGTGGTTGCTGACCGCCTCAAATCACAATCGCCTGAAGCCATTGAACAACTGCGGC
ATCTGGGAGTGAATACCATAGCCATGCTGACTGGCGACCGTGAAGAGCAGGCCCTTCCTGTGGCCCAGAGGCTCGGCCTG
GATGTTCTCAAGGCAGGGTTGCTGCCCGAAGGAAAAGCCGAGGCCCTTGAATCTCTTGGCCCGGTAGAAAACACCATCTT
TGTGGGAGACGGCATCAACGATGCTCCTGTTCTGGCCACAGCGGGGGTGGGGGTCGCCATGGGTGGACTTGGCTCGGAAG
CGGCCATTGAAACTGCTGATGTTGTGATTCTTGACGACAATCCCGCACGCCTGCCCGAACTGCTGCGCATTGCCCGCCGC
ACACGCACCATTGTGTGGCAGAACATTATTATGGCTCTCGGCATCAAGAGCCTGTTCATGGGGCTTGGCATCGTGGGCCT
TTCCGGCCTGTGGGAAGCCGTATTCGCAGACGTGGGCGTAGCTCTTATGGCCGTGCTCAACGCAGCGCGCGCCGGAAAGA
TTGAACAATAA

Upstream 100 bases:

>100_bases
CAGATGAAATTGACGGCAGTGATGATACCGATGCTGCCCCCGGGACCGACACGGACTCCGCCACTAACTAAGCCCTCGAG
GCCTCATACAGGAGACCCCC

Downstream 100 bases:

>100_bases
AAGAAGCTGGAGGGCAGGAAACATATTGAAATGTCCTGCCCTCCGGCGTTCATTGCACATTGGCAAGAGCGGCCGCGCTT
CGCGCGGTTTCAGGCTGAAT

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSHCSAKNHNHSNGHACACNSTTGTLAPIPTPDTQNCASSSAGPTAPCGTTEEEEQHGCGCSSCGCHDHSHEHGSGDERR
ELVIMGISAVLFGIGMVADEAMARYVPNWLVIAVFYALPYFLCGYDVLHLGLRSIVKKDFFNEFTLMGGATIAAIALGQL
PEAVGVMLFYRIGEFVQERAAGHSRRSVKALLAARPSTAHEMLDDGTTRDVQPEDLGPGSHILVRPGEKIPLDGTVLEGN
SQVDTSPLTGESVPLLLKPGSRALAGTINLNGAIRMEVTAPFAESSIARILEMVENAAARKAPTERFITRMARWYTPAVT
GLALLVAVVPPIIGLGDFSQWLYRALVLLVISCPCALLISIPLGYFGGIGAASRRGILIKGGAVLDKLRDIRVAALDKTG
TLTEGVFEVNAVLPALGTDSTELLQAAALAESRSNHPIARSVIRAAEHANIVTDDSTITAMREIPGKGVEATTYDTTLLA
GNAALMEANGIAPQAVDMPGSIVQVARNGRLLGALVVADRLKSQSPEAIEQLRHLGVNTIAMLTGDREEQALPVAQRLGL
DVLKAGLLPEGKAEALESLGPVENTIFVGDGINDAPVLATAGVGVAMGGLGSEAAIETADVVILDDNPARLPELLRIARR
TRTIVWQNIIMALGIKSLFMGLGIVGLSGLWEAVFADVGVALMAVLNAARAGKIEQ

Sequences:

>Translated_696_residues
MSHCSAKNHNHSNGHACACNSTTGTLAPIPTPDTQNCASSSAGPTAPCGTTEEEEQHGCGCSSCGCHDHSHEHGSGDERR
ELVIMGISAVLFGIGMVADEAMARYVPNWLVIAVFYALPYFLCGYDVLHLGLRSIVKKDFFNEFTLMGGATIAAIALGQL
PEAVGVMLFYRIGEFVQERAAGHSRRSVKALLAARPSTAHEMLDDGTTRDVQPEDLGPGSHILVRPGEKIPLDGTVLEGN
SQVDTSPLTGESVPLLLKPGSRALAGTINLNGAIRMEVTAPFAESSIARILEMVENAAARKAPTERFITRMARWYTPAVT
GLALLVAVVPPIIGLGDFSQWLYRALVLLVISCPCALLISIPLGYFGGIGAASRRGILIKGGAVLDKLRDIRVAALDKTG
TLTEGVFEVNAVLPALGTDSTELLQAAALAESRSNHPIARSVIRAAEHANIVTDDSTITAMREIPGKGVEATTYDTTLLA
GNAALMEANGIAPQAVDMPGSIVQVARNGRLLGALVVADRLKSQSPEAIEQLRHLGVNTIAMLTGDREEQALPVAQRLGL
DVLKAGLLPEGKAEALESLGPVENTIFVGDGINDAPVLATAGVGVAMGGLGSEAAIETADVVILDDNPARLPELLRIARR
TRTIVWQNIIMALGIKSLFMGLGIVGLSGLWEAVFADVGVALMAVLNAARAGKIEQ
>Mature_695_residues
SHCSAKNHNHSNGHACACNSTTGTLAPIPTPDTQNCASSSAGPTAPCGTTEEEEQHGCGCSSCGCHDHSHEHGSGDERRE
LVIMGISAVLFGIGMVADEAMARYVPNWLVIAVFYALPYFLCGYDVLHLGLRSIVKKDFFNEFTLMGGATIAAIALGQLP
EAVGVMLFYRIGEFVQERAAGHSRRSVKALLAARPSTAHEMLDDGTTRDVQPEDLGPGSHILVRPGEKIPLDGTVLEGNS
QVDTSPLTGESVPLLLKPGSRALAGTINLNGAIRMEVTAPFAESSIARILEMVENAAARKAPTERFITRMARWYTPAVTG
LALLVAVVPPIIGLGDFSQWLYRALVLLVISCPCALLISIPLGYFGGIGAASRRGILIKGGAVLDKLRDIRVAALDKTGT
LTEGVFEVNAVLPALGTDSTELLQAAALAESRSNHPIARSVIRAAEHANIVTDDSTITAMREIPGKGVEATTYDTTLLAG
NAALMEANGIAPQAVDMPGSIVQVARNGRLLGALVVADRLKSQSPEAIEQLRHLGVNTIAMLTGDREEQALPVAQRLGLD
VLKAGLLPEGKAEALESLGPVENTIFVGDGINDAPVLATAGVGVAMGGLGSEAAIETADVVILDDNPARLPELLRIARRT
RTIVWQNIIMALGIKSLFMGLGIVGLSGLWEAVFADVGVALMAVLNAARAGKIEQ

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=583, Percent_Identity=28.6449399656947, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI115529486, Length=601, Percent_Identity=26.7886855241265, Blast_Score=197, Evalue=4e-50,
Organism=Homo sapiens, GI55743073, Length=504, Percent_Identity=29.3650793650794, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1789879, Length=569, Percent_Identity=39.1915641476274, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1786691, Length=516, Percent_Identity=31.3953488372093, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786914, Length=502, Percent_Identity=30.2788844621514, Blast_Score=152, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17556548, Length=589, Percent_Identity=26.6553480475382, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320475, Length=532, Percent_Identity=29.5112781954887, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=509, Percent_Identity=25.5402750491159, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321430, Length=605, Percent_Identity=22.3140495867769, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221329854, Length=351, Percent_Identity=27.0655270655271, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 73104; Mature: 72973

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHCSAKNHNHSNGHACACNSTTGTLAPIPTPDTQNCASSSAGPTAPCGTTEEEEQHGCG
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCC
CSSCGCHDHSHEHGSGDERRELVIMGISAVLFGIGMVADEAMARYVPNWLVIAVFYALPY
CCCCCCCCCCCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FLCGYDVLHLGLRSIVKKDFFNEFTLMGGATIAAIALGQLPEAVGVMLFYRIGEFVQERA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AGHSRRSVKALLAARPSTAHEMLDDGTTRDVQPEDLGPGSHILVRPGEKIPLDGTVLEGN
CCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCC
SQVDTSPLTGESVPLLLKPGSRALAGTINLNGAIRMEVTAPFAESSIARILEMVENAAAR
CCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
KAPTERFITRMARWYTPAVTGLALLVAVVPPIIGLGDFSQWLYRALVLLVISCPCALLIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPLGYFGGIGAASRRGILIKGGAVLDKLRDIRVAALDKTGTLTEGVFEVNAVLPALGTDS
HHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCH
TELLQAAALAESRSNHPIARSVIRAAEHANIVTDDSTITAMREIPGKGVEATTYDTTLLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCHHHHHHHHCCCCCCEEEECCCEEEE
GNAALMEANGIAPQAVDMPGSIVQVARNGRLLGALVVADRLKSQSPEAIEQLRHLGVNTI
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
AMLTGDREEQALPVAQRLGLDVLKAGLLPEGKAEALESLGPVENTIFVGDGINDAPVLAT
EEEECCCHHHHCHHHHHHCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEE
AGVGVAMGGLGSEAAIETADVVILDDNPARLPELLRIARRTRTIVWQNIIMALGIKSLFM
CCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIVGLSGLWEAVFADVGVALMAVLNAARAGKIEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SHCSAKNHNHSNGHACACNSTTGTLAPIPTPDTQNCASSSAGPTAPCGTTEEEEQHGCG
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCC
CSSCGCHDHSHEHGSGDERRELVIMGISAVLFGIGMVADEAMARYVPNWLVIAVFYALPY
CCCCCCCCCCCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FLCGYDVLHLGLRSIVKKDFFNEFTLMGGATIAAIALGQLPEAVGVMLFYRIGEFVQERA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AGHSRRSVKALLAARPSTAHEMLDDGTTRDVQPEDLGPGSHILVRPGEKIPLDGTVLEGN
CCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCC
SQVDTSPLTGESVPLLLKPGSRALAGTINLNGAIRMEVTAPFAESSIARILEMVENAAAR
CCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
KAPTERFITRMARWYTPAVTGLALLVAVVPPIIGLGDFSQWLYRALVLLVISCPCALLIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPLGYFGGIGAASRRGILIKGGAVLDKLRDIRVAALDKTGTLTEGVFEVNAVLPALGTDS
HHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCH
TELLQAAALAESRSNHPIARSVIRAAEHANIVTDDSTITAMREIPGKGVEATTYDTTLLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCHHHHHHHHCCCCCCEEEECCCEEEE
GNAALMEANGIAPQAVDMPGSIVQVARNGRLLGALVVADRLKSQSPEAIEQLRHLGVNTI
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
AMLTGDREEQALPVAQRLGLDVLKAGLLPEGKAEALESLGPVENTIFVGDGINDAPVLAT
EEEECCCHHHHCHHHHHHCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEE
AGVGVAMGGLGSEAAIETADVVILDDNPARLPELLRIARRTRTIVWQNIIMALGIKSLFM
CCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIVGLSGLWEAVFADVGVALMAVLNAARAGKIEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]