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The map label for this gene is guaD [H]

Identifier: 220904518

GI number: 220904518

Start: 1468434

End: 1468901

Strand: Direct

Name: guaD [H]

Synonym: Ddes_1249

Alternate gene names: 220904518

Gene position: 1468434-1468901 (Clockwise)

Preceding gene: 220904517

Following gene: 220904519

Centisome position: 51.1

GC content: 49.79

Gene sequence:

>468_bases
ATGGAAAGCAGGCGTTTTATGGAAAGGGCCATTGAACTCTCCAAACAAAGCATGGCAGCCGGAGGGGGACCGTTTGGAGC
GGTGATCGTGCGGGACGGGAAAATCATAGGTGAGGGGACAAATAACGTTACCCCCCATAACGATCCTACAGCACATGCCG
AAGTGGAGGCCATCCGGAATGCCTGTCGTGCGCTTGAAACGTTCGACCTCTCAGGCTCTGCAATATTTACAAGTTGCGAG
CCTTGTCCTATGTGTCTCAGCGCCATATGGTGGGCGCGCATTGGGAAAATATATTTTTCCAATACTAAAGAAGACGCTGC
TGATGCCGGTTTTGACGATGCAGCCATATATTGTGAAATCTCCAAAAAACTGAATGAGCGCACACTGCCTATCGAACAGC
TTTATTGCAAAACCAGTTCCGAAGTTTTCCGGCAGTGGCAGTCTTGCGAAGGGAAAACAGCGTACTGA

Upstream 100 bases:

>100_bases
CAGTTGCCGCAACAGGACTCGCGAGCCGCTCCATTGGTTGCCGTCTTTTGTGTAAACGGATAAGAACAATACAAGCATGA
AAAATAATTCGGGAGTCGGC

Downstream 100 bases:

>100_bases
GTCGCGAAAGTCCCCACCGCGGACCTTTTTCACGTTGTGCTGCAAAAATATTTTGCCTGGTCGCCCCGCTGTCTTTCCCA
ATATACCTGGACGGCGGAGG

Product: CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MESRRFMERAIELSKQSMAAGGGPFGAVIVRDGKIIGEGTNNVTPHNDPTAHAEVEAIRNACRALETFDLSGSAIFTSCE
PCPMCLSAIWWARIGKIYFSNTKEDAADAGFDDAAIYCEISKKLNERTLPIEQLYCKTSSEVFRQWQSCEGKTAY

Sequences:

>Translated_155_residues
MESRRFMERAIELSKQSMAAGGGPFGAVIVRDGKIIGEGTNNVTPHNDPTAHAEVEAIRNACRALETFDLSGSAIFTSCE
PCPMCLSAIWWARIGKIYFSNTKEDAADAGFDDAAIYCEISKKLNERTLPIEQLYCKTSSEVFRQWQSCEGKTAY
>Mature_155_residues
MESRRFMERAIELSKQSMAAGGGPFGAVIVRDGKIIGEGTNNVTPHNDPTAHAEVEAIRNACRALETFDLSGSAIFTSCE
PCPMCLSAIWWARIGKIYFSNTKEDAADAGFDDAAIYCEISKKLNERTLPIEQLYCKTSSEVFRQWQSCEGKTAY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=105, Percent_Identity=34.2857142857143, Blast_Score=78, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17554608, Length=151, Percent_Identity=46.3576158940397, Blast_Score=145, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17555996, Length=135, Percent_Identity=44.4444444444444, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17112; Mature: 17112

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRRFMERAIELSKQSMAAGGGPFGAVIVRDGKIIGEGTNNVTPHNDPTAHAEVEAIRN
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHH
ACRALETFDLSGSAIFTSCEPCPMCLSAIWWARIGKIYFSNTKEDAADAGFDDAAIYCEI
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEE
SKKLNERTLPIEQLYCKTSSEVFRQWQSCEGKTAY
HHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MESRRFMERAIELSKQSMAAGGGPFGAVIVRDGKIIGEGTNNVTPHNDPTAHAEVEAIRN
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHH
ACRALETFDLSGSAIFTSCEPCPMCLSAIWWARIGKIYFSNTKEDAADAGFDDAAIYCEI
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEE
SKKLNERTLPIEQLYCKTSSEVFRQWQSCEGKTAY
HHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]