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The map label for this gene is degP [H]

Identifier: 220904478

GI number: 220904478

Start: 1421061

End: 1422488

Strand: Direct

Name: degP [H]

Synonym: Ddes_1208

Alternate gene names: 220904478

Gene position: 1421061-1422488 (Clockwise)

Preceding gene: 220904477

Following gene: 220904479

Centisome position: 49.46

GC content: 53.78

Gene sequence:

>1428_bases
ATGTTTATAAAAAAATGCCTTTCGGGCCTGCTCGCAGTGACTTTTGTCGTTGCCGCGCAGTTTGCCCAGGCAGGAAACCT
GCCGGATTTCAGCGAGCTGGCAGCCAAAAGCGGCCCCGCTGTGGTCAATATCAACACTGAAAAAATGGCTGCCAGCGGCG
GCTCTGAAGAGTTTTTTGGCGAGATGTTCCGTAATATGCCCCCTGGGTTTGAAAAATTTTTTGACCAGTTCGGCGGCAAG
CGGGACGGCAAGCGCCCCCAGTCCAGACAAAAATCGCTCGGCTCCGGTTTTCTGGTATCGGCGGATGGCTTTATCGTCAC
CAACAACCATGTGGTGGCCGATGCTGACGTTATTCGCGTAACGCTGGATCAGGAGAACGGCAAGAGCGAATCCTTCACGG
CGACCCTTATCGGCGCTGATGAAGAAACCGACCTGGCTCTGCTGAAAGTGGAAACCAAAAAGAATCTGCCTTTTCTGGTT
TTCGGCAATTCCGACGAACTCAAGGTGGGCGAGTGGCTGCTGGCCATCGGCAATCCCTTTGGCTTGGACCACACGGTGAC
CGCGGGTATTCTGTCGGCCAAAAACCGCAACATTCATGCCGGTCCCTTTGACAACTTTCTTCAGACTGATGCCTCCATCA
ACCCCGGAAACAGCGGCGGACCTCTGCTGAACATGCAGGGGCAGGTGGTAGGCATCAATACGGCCATCATTGCCAGCGGG
CAGGGCATTGGTTTCGCAATACCCAGCAACATGGCTGCCAAGATCATTGATCAGATCAAAAGCGGCAAAAAAGTCAGCCG
TGGCTGGATTGGCGTTACCATCCAGGATGTTGAAGAAAATACCGCAAAGGCCTTGGGCATGAAAGACGCCAAGGGCGCGC
TTGTGGGCAGCGTTATGGAAAATGAACCTGCCGGCAAGGGCGGCATGAAAGACGGCGACATCATCCTGGCTGTAGATGGA
AAGGATATTGATGACGCGTCGGCCCTGCTGCGTGCCATTGCCGAAAAGACCCCCGGCAGTAAAGCCGTAATCAAGGTATG
GCGCGATGGAAAGGTTCTTGACCTTACAGTCACCTTGGGTGAGCGTCAGTCAACTTCTCAGGCCTCTGCATCTGGAAAGG
GCGGTCCCAAACAAAACGAAGGCCTCCTTGGCATCGCTGTGCGACCTCTCAATGATACCGAACGCCGGGATATGAAGATT
GATAAAAATGAAGGCCTGCTTATTGTGGATGTCACCCCCAGCAAACCTGCGGCCGAAGCTGACTTGCGCCCCGGTGACGT
AATCCTCAAGGCAAACCTCAAGCCTGTGAATACGTCAGAGGCATTGTCAAAAATTGTTAATGAAGAGGGCGCAAAGCGTG
GGGCCATCATGCTGCAGATTTCGCGCCGCGGCGACGTGTATTTCCGCACAATTCCTTTGAGCAAATAA

Upstream 100 bases:

>100_bases
AGCATGCCAGCAAGGGGAGCGGTTCTGCAAACACCGGAATGAACACTTTGGCACAAGCTTTGCATAAGGCAATGCAAAAC
AAGTAACCAGGAGTTTTTCC

Downstream 100 bases:

>100_bases
GAAACATCGCTGACTCTGGCAGAACAAGGACTGCAAGGGCTGCTCCTCTGGGGCAGCCCTTTTCTGTGCGGAGGTAAAAG
ATAATCTGGTCTGAATGTCA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MFIKKCLSGLLAVTFVVAAQFAQAGNLPDFSELAAKSGPAVVNINTEKMAASGGSEEFFGEMFRNMPPGFEKFFDQFGGK
RDGKRPQSRQKSLGSGFLVSADGFIVTNNHVVADADVIRVTLDQENGKSESFTATLIGADEETDLALLKVETKKNLPFLV
FGNSDELKVGEWLLAIGNPFGLDHTVTAGILSAKNRNIHAGPFDNFLQTDASINPGNSGGPLLNMQGQVVGINTAIIASG
QGIGFAIPSNMAAKIIDQIKSGKKVSRGWIGVTIQDVEENTAKALGMKDAKGALVGSVMENEPAGKGGMKDGDIILAVDG
KDIDDASALLRAIAEKTPGSKAVIKVWRDGKVLDLTVTLGERQSTSQASASGKGGPKQNEGLLGIAVRPLNDTERRDMKI
DKNEGLLIVDVTPSKPAAEADLRPGDVILKANLKPVNTSEALSKIVNEEGAKRGAIMLQISRRGDVYFRTIPLSK

Sequences:

>Translated_475_residues
MFIKKCLSGLLAVTFVVAAQFAQAGNLPDFSELAAKSGPAVVNINTEKMAASGGSEEFFGEMFRNMPPGFEKFFDQFGGK
RDGKRPQSRQKSLGSGFLVSADGFIVTNNHVVADADVIRVTLDQENGKSESFTATLIGADEETDLALLKVETKKNLPFLV
FGNSDELKVGEWLLAIGNPFGLDHTVTAGILSAKNRNIHAGPFDNFLQTDASINPGNSGGPLLNMQGQVVGINTAIIASG
QGIGFAIPSNMAAKIIDQIKSGKKVSRGWIGVTIQDVEENTAKALGMKDAKGALVGSVMENEPAGKGGMKDGDIILAVDG
KDIDDASALLRAIAEKTPGSKAVIKVWRDGKVLDLTVTLGERQSTSQASASGKGGPKQNEGLLGIAVRPLNDTERRDMKI
DKNEGLLIVDVTPSKPAAEADLRPGDVILKANLKPVNTSEALSKIVNEEGAKRGAIMLQISRRGDVYFRTIPLSK
>Mature_475_residues
MFIKKCLSGLLAVTFVVAAQFAQAGNLPDFSELAAKSGPAVVNINTEKMAASGGSEEFFGEMFRNMPPGFEKFFDQFGGK
RDGKRPQSRQKSLGSGFLVSADGFIVTNNHVVADADVIRVTLDQENGKSESFTATLIGADEETDLALLKVETKKNLPFLV
FGNSDELKVGEWLLAIGNPFGLDHTVTAGILSAKNRNIHAGPFDNFLQTDASINPGNSGGPLLNMQGQVVGINTAIIASG
QGIGFAIPSNMAAKIIDQIKSGKKVSRGWIGVTIQDVEENTAKALGMKDAKGALVGSVMENEPAGKGGMKDGDIILAVDG
KDIDDASALLRAIAEKTPGSKAVIKVWRDGKVLDLTVTLGERQSTSQASASGKGGPKQNEGLLGIAVRPLNDTERRDMKI
DKNEGLLIVDVTPSKPAAEADLRPGDVILKANLKPVNTSEALSKIVNEEGAKRGAIMLQISRRGDVYFRTIPLSK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=249, Percent_Identity=38.9558232931727, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI22129776, Length=261, Percent_Identity=37.9310344827586, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI24308541, Length=255, Percent_Identity=35.6862745098039, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI7019477, Length=281, Percent_Identity=34.8754448398576, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1786356, Length=488, Percent_Identity=34.4262295081967, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789629, Length=469, Percent_Identity=34.5415778251599, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789630, Length=374, Percent_Identity=35.5614973262032, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24646839, Length=314, Percent_Identity=32.1656050955414, Blast_Score=148, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50274; Mature: 50274

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIKKCLSGLLAVTFVVAAQFAQAGNLPDFSELAAKSGPAVVNINTEKMAASGGSEEFFG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECHHHHCCCCCCHHHHH
EMFRNMPPGFEKFFDQFGGKRDGKRPQSRQKSLGSGFLVSADGFIVTNNHVVADADVIRV
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEEEECCEEEECCEEEEE
TLDQENGKSESFTATLIGADEETDLALLKVETKKNLPFLVFGNSDELKVGEWLLAIGNPF
EEECCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCC
GLDHTVTAGILSAKNRNIHAGPFDNFLQTDASINPGNSGGPLLNMQGQVVGINTAIIASG
CCCHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEECC
QGIGFAIPSNMAAKIIDQIKSGKKVSRGWIGVTIQDVEENTAKALGMKDAKGALVGSVME
CCCEEECCCHHHHHHHHHHHCCCEECCCEEEEEEECCCCHHHHHCCCCCCCCHHHHHHHH
NEPAGKGGMKDGDIILAVDGKDIDDASALLRAIAEKTPGSKAVIKVWRDGKVLDLTVTLG
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEEEC
ERQSTSQASASGKGGPKQNEGLLGIAVRPLNDTERRDMKIDKNEGLLIVDVTPSKPAAEA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCC
DLRPGDVILKANLKPVNTSEALSKIVNEEGAKRGAIMLQISRRGDVYFRTIPLSK
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCC
>Mature Secondary Structure
MFIKKCLSGLLAVTFVVAAQFAQAGNLPDFSELAAKSGPAVVNINTEKMAASGGSEEFFG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECHHHHCCCCCCHHHHH
EMFRNMPPGFEKFFDQFGGKRDGKRPQSRQKSLGSGFLVSADGFIVTNNHVVADADVIRV
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEEEECCEEEECCEEEEE
TLDQENGKSESFTATLIGADEETDLALLKVETKKNLPFLVFGNSDELKVGEWLLAIGNPF
EEECCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCC
GLDHTVTAGILSAKNRNIHAGPFDNFLQTDASINPGNSGGPLLNMQGQVVGINTAIIASG
CCCHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEECC
QGIGFAIPSNMAAKIIDQIKSGKKVSRGWIGVTIQDVEENTAKALGMKDAKGALVGSVME
CCCEEECCCHHHHHHHHHHHCCCEECCCEEEEEEECCCCHHHHHCCCCCCCCHHHHHHHH
NEPAGKGGMKDGDIILAVDGKDIDDASALLRAIAEKTPGSKAVIKVWRDGKVLDLTVTLG
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEEEC
ERQSTSQASASGKGGPKQNEGLLGIAVRPLNDTERRDMKIDKNEGLLIVDVTPSKPAAEA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCC
DLRPGDVILKANLKPVNTSEALSKIVNEEGAKRGAIMLQISRRGDVYFRTIPLSK
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]