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The map label for this gene is tpiA [H]

Identifier: 220904446

GI number: 220904446

Start: 1384224

End: 1384991

Strand: Direct

Name: tpiA [H]

Synonym: Ddes_1176

Alternate gene names: 220904446

Gene position: 1384224-1384991 (Clockwise)

Preceding gene: 220904445

Following gene: 220904447

Centisome position: 48.17

GC content: 54.3

Gene sequence:

>768_bases
ATGCACAAGATTATCGCTGCAAACTGGAAGATGTACAAAGACCGTACTCAGGCCGCCACAACCGCTGGCGAGCTTGCGGC
CGTTTTGCCCGAAATTTTACCTGCGGGACGCGAAGTTATCGTCTTTCCGCCTTTTACCGCCATTGAGAGCGTAGCTCGTG
TATTTGACGGTAAAAAAGGGCTGGCTGTGGGCGGGCAGAATTTTTACCCCGCGCCGGAAGGTGCTTTTACGGGTGAAATC
TCTATTGATATGCTGCGTGATGTCGGGGCGCAATGGGTGCTTGCCGGACATTCCGAACGCAGGCATGTCTTTGGCGAGAG
TGATGAGCTTGTGGCCCGCAAGGCTGTGTTTGCCCTTAGCCATGGCCTCAAAACCATGCTTTGCATAGGGGAAAAACTTG
AAGAGCGTGAACAGGGCAGCCTTTATGCTGTACTTGAGCGGCAGCTGACGGCTTTTTTTGAAGCCAGACCCGACGGTATG
GCTGGTGAAACCCTGCCGGGGCGCTTGGCCATCGCCTATGAACCCGTGTGGGCCATAGGTACAGGCAAGGTGGCTGGCCC
TGGTGAAGTACGTGAGGCGCACGGCGTTACGCGGGCCTTGCTTGAAAGATTTGTGGGTGATTCCGGCAAAAAACTGCCGA
TTTTGTATGGCGGCAGCGTAAAACCGGATAATGCCGGAGCACTTATCGCCCTTGACAATGTGGATGGTCTTTTGGTAGGA
GGAGCCTCTTTAGAGGCGCAAAGCTTCTTACAAATTATCGGGGCCTGA

Upstream 100 bases:

>100_bases
TCGGCCTGCGCCGTAAGTATTATGCCGATACGGGTGAAGACGCCCTTATTTACCAGTGCGAGCTGAATTCCTGTCAGCTT
TAACGCCGCAAGGGGTATGT

Downstream 100 bases:

>100_bases
TGCCCAACTTCTGGCGCGCCATCGGGCTGTGGCCGGACGGCGAGGAGGAATACGTGCAGACTCTTATTCTTACGCTGCAT
ATCATTGTATGCGTGTTGCT

Product: Triose-phosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MHKIIAANWKMYKDRTQAATTAGELAAVLPEILPAGREVIVFPPFTAIESVARVFDGKKGLAVGGQNFYPAPEGAFTGEI
SIDMLRDVGAQWVLAGHSERRHVFGESDELVARKAVFALSHGLKTMLCIGEKLEEREQGSLYAVLERQLTAFFEARPDGM
AGETLPGRLAIAYEPVWAIGTGKVAGPGEVREAHGVTRALLERFVGDSGKKLPILYGGSVKPDNAGALIALDNVDGLLVG
GASLEAQSFLQIIGA

Sequences:

>Translated_255_residues
MHKIIAANWKMYKDRTQAATTAGELAAVLPEILPAGREVIVFPPFTAIESVARVFDGKKGLAVGGQNFYPAPEGAFTGEI
SIDMLRDVGAQWVLAGHSERRHVFGESDELVARKAVFALSHGLKTMLCIGEKLEEREQGSLYAVLERQLTAFFEARPDGM
AGETLPGRLAIAYEPVWAIGTGKVAGPGEVREAHGVTRALLERFVGDSGKKLPILYGGSVKPDNAGALIALDNVDGLLVG
GASLEAQSFLQIIGA
>Mature_255_residues
MHKIIAANWKMYKDRTQAATTAGELAAVLPEILPAGREVIVFPPFTAIESVARVFDGKKGLAVGGQNFYPAPEGAFTGEI
SIDMLRDVGAQWVLAGHSERRHVFGESDELVARKAVFALSHGLKTMLCIGEKLEEREQGSLYAVLERQLTAFFEARPDGM
AGETLPGRLAIAYEPVWAIGTGKVAGPGEVREAHGVTRALLERFVGDSGKKLPILYGGSVKPDNAGALIALDNVDGLLVG
GASLEAQSFLQIIGA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=252, Percent_Identity=43.2539682539683, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI226529917, Length=253, Percent_Identity=43.0830039525692, Blast_Score=182, Evalue=2e-46,
Organism=Escherichia coli, GI1790353, Length=254, Percent_Identity=39.7637795275591, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17536593, Length=252, Percent_Identity=44.8412698412698, Blast_Score=183, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6320255, Length=225, Percent_Identity=44.8888888888889, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28572008, Length=253, Percent_Identity=43.0830039525692, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28572006, Length=253, Percent_Identity=43.0830039525692, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28572004, Length=253, Percent_Identity=43.0830039525692, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27139; Mature: 27139

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIIAANWKMYKDRTQAATTAGELAAVLPEILPAGREVIVFPPFTAIESVARVFDGKKG
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCC
LAVGGQNFYPAPEGAFTGEISIDMLRDVGAQWVLAGHSERRHVFGESDELVARKAVFALS
EEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HGLKTMLCIGEKLEEREQGSLYAVLERQLTAFFEARPDGMAGETLPGRLAIAYEPVWAIG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEC
TGKVAGPGEVREAHGVTRALLERFVGDSGKKLPILYGGSVKPDNAGALIALDNVDGLLVG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEE
GASLEAQSFLQIIGA
CCCCCHHHHHHHHCC
>Mature Secondary Structure
MHKIIAANWKMYKDRTQAATTAGELAAVLPEILPAGREVIVFPPFTAIESVARVFDGKKG
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCC
LAVGGQNFYPAPEGAFTGEISIDMLRDVGAQWVLAGHSERRHVFGESDELVARKAVFALS
EEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HGLKTMLCIGEKLEEREQGSLYAVLERQLTAFFEARPDGMAGETLPGRLAIAYEPVWAIG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEC
TGKVAGPGEVREAHGVTRALLERFVGDSGKKLPILYGGSVKPDNAGALIALDNVDGLLVG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEE
GASLEAQSFLQIIGA
CCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA