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The map label for this gene is dapL

Identifier: 220904421

GI number: 220904421

Start: 1355973

End: 1357199

Strand: Direct

Name: dapL

Synonym: Ddes_1151

Alternate gene names: 220904421

Gene position: 1355973-1357199 (Clockwise)

Preceding gene: 220904420

Following gene: 220904423

Centisome position: 47.19

GC content: 53.22

Gene sequence:

>1227_bases
ATGGCTACCGTAAACAGCAATTTTCTCAAACTCCAGAGCAATTATCTTTTTGCGGACATCGCCCGTAAGGTTACGGCTTT
TAAGAATGCCAACCCCGACAGGCGCGTGATCAGCCTGGGCATAGGCGATGTTACACGTCCCTTGCCGCCTGCTGTCATCC
AGGCTTTGCACAAGGCCGTGGATGAAATGGGTGATGCTACGCTTTTTCGCGGATATGGTCCAGAACAGGGGTATGCTTTT
TTGCGTGACGTCATTATGCAGTATGACTACAAGGTGCGTGGCGTTACCCTTGCCCCCGACGAAATATTCGTCAGCGATGG
CGCGAAACCCGATGTGGGAAATTTTCAGGAGCTTTTCGCTCAGGACAGCATCGTGGCAGTTACCGACCCGGTGTACCCGG
TATATGTCGACTCCAATGTTATGGCAGGGCGTTCGGGCGAAATAAAGGACAGTCAGTGGAGCAGAATTGTCTATCTGCCG
TGCATAAAAGAAAATGACTTCGTGCCGGACTTTCCTGCCGTCCGGCCGGATATGATCTATCTTTGCTATCCCAATAATCC
TACAGGCACGGTGCTTTCACGTGCGGCTTTGCAAGGATGGGTGGAGTACGCCAGACGCGAGGGTTGCGTTATTCTGTATG
ATTCCGCCTATGAAGCTTTTATCACCGAAGCTGACATTCCTCACAGCATTTACGAAATTGATGGTGCGGAAGAAGTTGCA
GTGGAGTTTCGCAGCTTTTCAAAAACTGCCGGATTTACCGGCCTGCGCTGCGCCTATACCGTGGTACCCAAGGCTCTGCG
CATCAGTGACGGCAAGAGCGGCTCTGTAAGCCTGAACGCGCTTTGGAATCGTCGTCAATGCACCAAGTACAACGGTTGCC
CCTATATTGTGCAGCGTGCCGCCGAAGCCGTGTATAGCGAACGGGGACAAAGTGAAATCATGGGGATCATTGCAGGTTAT
CAACGCAATGCCGCCATGTTGCGCACGGCGGCAAGTGAAATGGGTTTTGCCGTATACGGTGGCGTGAACGCTCCCTATAT
CTGGTTACGTGTGCCTGACAACACAGATTCCTGGGGATTTTTTGACAGGCTGCTGCAGCAGGCAGGGCTGGTCTGCACTC
CGGGCGCAGGTTTTGGCATTTCGGGCGAGGGCTATGTGCGCCTGACGGCATTCGGCTCGCCTGAAGATACGGAAGAAGCC
ATACATAGGCTGCGCTCCCTGTGCTGA

Upstream 100 bases:

>100_bases
TCCACTGGGATGAAGCCAGTAACCACGTATACATGACCGGCGGCGCGGTGACCGTTTTTTCCGGCGAATACTACATTTGA
ACCAGAATGAAGAGGATGGC

Downstream 100 bases:

>100_bases
TATTATACTGGCCTGATTGTGGAAAATGATTGAAGGTCGCGGGCTGCCTTGCATTCGTCGCACAAGCCTTCGGGGTTTGC
GGTCTCAAACAGGGCGGGAC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MATVNSNFLKLQSNYLFADIARKVTAFKNANPDRRVISLGIGDVTRPLPPAVIQALHKAVDEMGDATLFRGYGPEQGYAF
LRDVIMQYDYKVRGVTLAPDEIFVSDGAKPDVGNFQELFAQDSIVAVTDPVYPVYVDSNVMAGRSGEIKDSQWSRIVYLP
CIKENDFVPDFPAVRPDMIYLCYPNNPTGTVLSRAALQGWVEYARREGCVILYDSAYEAFITEADIPHSIYEIDGAEEVA
VEFRSFSKTAGFTGLRCAYTVVPKALRISDGKSGSVSLNALWNRRQCTKYNGCPYIVQRAAEAVYSERGQSEIMGIIAGY
QRNAAMLRTAASEMGFAVYGGVNAPYIWLRVPDNTDSWGFFDRLLQQAGLVCTPGAGFGISGEGYVRLTAFGSPEDTEEA
IHRLRSLC

Sequences:

>Translated_408_residues
MATVNSNFLKLQSNYLFADIARKVTAFKNANPDRRVISLGIGDVTRPLPPAVIQALHKAVDEMGDATLFRGYGPEQGYAF
LRDVIMQYDYKVRGVTLAPDEIFVSDGAKPDVGNFQELFAQDSIVAVTDPVYPVYVDSNVMAGRSGEIKDSQWSRIVYLP
CIKENDFVPDFPAVRPDMIYLCYPNNPTGTVLSRAALQGWVEYARREGCVILYDSAYEAFITEADIPHSIYEIDGAEEVA
VEFRSFSKTAGFTGLRCAYTVVPKALRISDGKSGSVSLNALWNRRQCTKYNGCPYIVQRAAEAVYSERGQSEIMGIIAGY
QRNAAMLRTAASEMGFAVYGGVNAPYIWLRVPDNTDSWGFFDRLLQQAGLVCTPGAGFGISGEGYVRLTAFGSPEDTEEA
IHRLRSLC
>Mature_407_residues
ATVNSNFLKLQSNYLFADIARKVTAFKNANPDRRVISLGIGDVTRPLPPAVIQALHKAVDEMGDATLFRGYGPEQGYAFL
RDVIMQYDYKVRGVTLAPDEIFVSDGAKPDVGNFQELFAQDSIVAVTDPVYPVYVDSNVMAGRSGEIKDSQWSRIVYLPC
IKENDFVPDFPAVRPDMIYLCYPNNPTGTVLSRAALQGWVEYARREGCVILYDSAYEAFITEADIPHSIYEIDGAEEVAV
EFRSFSKTAGFTGLRCAYTVVPKALRISDGKSGSVSLNALWNRRQCTKYNGCPYIVQRAAEAVYSERGQSEIMGIIAGYQ
RNAAMLRTAASEMGFAVYGGVNAPYIWLRVPDNTDSWGFFDRLLQQAGLVCTPGAGFGISGEGYVRLTAFGSPEDTEEAI
HRLRSLC

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788722, Length=404, Percent_Identity=25, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788627, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_DESDA (B8IZX8)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479733.1
- ProteinModelPortal:   B8IZX8
- GeneID:   7284833
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1151
- HOGENOM:   HBG645860
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019942
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03542

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 45013; Mature: 44882

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 42-42 BINDING 72-72 BINDING 75-75 BINDING 109-109 BINDING 132-132 BINDING 186-186 BINDING 186-186 BINDING 214-214 BINDING 217-217 BINDING 245-245 BINDING 247-247 BINDING 256-256 BINDING 291-291 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVNSNFLKLQSNYLFADIARKVTAFKNANPDRRVISLGIGDVTRPLPPAVIQALHKAV
CCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
DEMGDATLFRGYGPEQGYAFLRDVIMQYDYKVRGVTLAPDEIFVSDGAKPDVGNFQELFA
HHHCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCHHHHHH
QDSIVAVTDPVYPVYVDSNVMAGRSGEIKDSQWSRIVYLPCIKENDFVPDFPAVRPDMIY
CCCEEEEECCCEEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEE
LCYPNNPTGTVLSRAALQGWVEYARREGCVILYDSAYEAFITEADIPHSIYEIDGAEEVA
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHEECCCCCCCEEECCCHHHHH
VEFRSFSKTAGFTGLRCAYTVVPKALRISDGKSGSVSLNALWNRRQCTKYNGCPYIVQRA
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
AEAVYSERGQSEIMGIIAGYQRNAAMLRTAASEMGFAVYGGVNAPYIWLRVPDNTDSWGF
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCCHHH
FDRLLQQAGLVCTPGAGFGISGEGYVRLTAFGSPEDTEEAIHRLRSLC
HHHHHHHCCCEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ATVNSNFLKLQSNYLFADIARKVTAFKNANPDRRVISLGIGDVTRPLPPAVIQALHKAV
CCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
DEMGDATLFRGYGPEQGYAFLRDVIMQYDYKVRGVTLAPDEIFVSDGAKPDVGNFQELFA
HHHCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCHHHHHH
QDSIVAVTDPVYPVYVDSNVMAGRSGEIKDSQWSRIVYLPCIKENDFVPDFPAVRPDMIY
CCCEEEEECCCEEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEE
LCYPNNPTGTVLSRAALQGWVEYARREGCVILYDSAYEAFITEADIPHSIYEIDGAEEVA
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHEECCCCCCCEEECCCHHHHH
VEFRSFSKTAGFTGLRCAYTVVPKALRISDGKSGSVSLNALWNRRQCTKYNGCPYIVQRA
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
AEAVYSERGQSEIMGIIAGYQRNAAMLRTAASEMGFAVYGGVNAPYIWLRVPDNTDSWGF
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCCHHH
FDRLLQQAGLVCTPGAGFGISGEGYVRLTAFGSPEDTEEAIHRLRSLC
HHHHHHHCCCEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA