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The map label for this gene is kefC [H]

Identifier: 220904261

GI number: 220904261

Start: 1154343

End: 1156373

Strand: Reverse

Name: kefC [H]

Synonym: Ddes_0988

Alternate gene names: 220904261

Gene position: 1156373-1154343 (Counterclockwise)

Preceding gene: 220904262

Following gene: 220904260

Centisome position: 40.24

GC content: 57.8

Gene sequence:

>2031_bases
ATGGACGTGCCCTTGCTCTATGAGATCGTGACCATCTTTCTGCTCTCCATCTTCGTCACCGTTACATGCAACAAAATCAA
GCTGCCTGCCACTGTAGGCTTTCTGCTCACAGGCGTTTTGTGCGGCCCGTCCCTGCTCGGCATAGTCAGCGACCGCGAAG
CCATTGATCATGTGGCTGAAATCGGCGTAGCCATGCTGCTTTTCACCATCGGCATGGAACTTTCCGGTGAGGCACTCAAC
CGCCTGAAGCGTCCGGTATTTCTGGGCGGCAGCCTGCAGATCGGCCTTACCGTACTGGCCGTGATGGGGCTGGCCCTTCT
GGGCGGCTACTCCTATCAGCAGGGTGTATTTATGGGCTGTCTGGTAGCCCTTTCATCGTCGGCCATTGTCTTGCGCATCA
TGCAGGAACGCGGCTCTACCAACACGCCCACAGGGCGGCTATCTCTTGCCATTCTGGTCTTTCAGGACATTATGGTGGCT
CCCATGCTGCTGTGCGTGCCCCTGCTTTCCGGCACGCTTGACCTTTCGCTGGAAAGCGCCTTTTTTTCCACACTGTGGGT
GGTGCTGGCCCTTGGGGGAGTGCTTCTTTTTGCGCGCTTCGGCCTCAACCGTCTCATGGAAGCCGTGGTACGCACACGCA
CCAGAGAAATCCTGCTGCTGACCACACTGGGGCTGTGCCTCGGCATGGCCTTGCTGACCAACACTCTGGGCCTTTCCCTT
TCGCTGGGCGCGTTCATGGCCGGGCTGCTGCTGGCCCGCTCCCAGTACAGCATGAGCGTCATTGCGGGCATTTTGCCCTA
TCGTGACGTATTTATGAGCCTTTTTTTCATTTCTGTAGGCATGATGCTCAATGTGGATTTCTTCGGAAAACACTTTTTTT
CCATCATCGGGCTTACTGCCTTGTTTATTGTGATCAAAAGCCTGCTCACGCTGCCCGCGGTACTCGTCCAGGGCTATCCC
CTGCGCGCGGCCATCATCACGTCTCTTTCCCTTGCCCAGGTGGGTGAGTTTGCCTTTGTACTGGCGGCCTCCGGCCTGAG
CGCCGGGCTTTTTGACATGGATGCCTATCAGAACTTTCTGGACGTAAGCGTGCTGACCATGATGCTTACGCCCGGGCTTA
TGACCATTGCCCCACGTCTGGCCGACCGTTTTGCCGGACAGCGCAACAGCGAGCAGCAAGAAGAATCCGGGCAGCAGGAA
GGCGAAAAACGCCTGGAAGATCATTTGATCATCGTTGGTTTCGGTATCAGCGGCAAGCATCTGGCCCATGTGGCCAAAGA
GTCGGGCATTGAATATACCATTCTGGAAATGAACCCGGAAACCGTGAGCCGCTACCGCCAGAAAGAACCCATCGCACACG
GAGACGCCTCGCAACCCGTGGTACTGGAGCATCTGGGCGTTACCCGGGCACGAGTGCTGGTGATTGTCATTTCCGACCCC
TCGGCTGTACGGGCCATTACCATTGAGGCGCGGCGCTTCAACCCCAACCTGCACATCATCGCGCGCACCCGTTTTGTTAC
CGAGGTGGCGGCCCTGCGCAGACTGGGAGCGGACGAGGTTATTGCGGAAGAGTTTGAAACTTCTGTTGAAATTTTTACCA
GAGTGCTGAGCCAGTACCTTGTACCCAGGCAGGATATAGACACGTTTGCCGCCCGGATCAGGCAGGAAAACTACCGCATG
ATACGCCGCATGAGTTCCGCGGTGGATTCTCTGGACAGCATTGTAAACCGCCTGCCCGACATGGGCGTACAGGCCATGCG
CCTTGGCGGGGCTTCCCCCCTGTGCGGCCGCAGCCTGGCGCAAACAGAATTGCGCCGCCGCCACGGGGTCACCGTTATTG
CCATCCTGCGGGAAGGCATAACCCATGCCTCGCCGGGTGCAGATGAAATTTTTGAACCCGGGGACATCGTTTACCTCTTC
GGCAAAACAGACAAGGTCATTGCCATAACCCCCCTGTTTTCCGGGCCTGTGCGCGAAAGCGCCAGGGACGGCAAGGGGGG
GATGCCGCAACCGGCCCGGCCCACAGCCTGA

Upstream 100 bases:

>100_bases
TCTTCTCTAAGCATATTAAATATAACCCATTTAATTTCATTCATAAAAGATGCTTGCACGGCTATGCCCGCAGTGATATT
TTGCGCGGCACGGAGGTCCT

Downstream 100 bases:

>100_bases
ATGTAGAGCAGGTTATTTCTTGAAATGGCCCTGGGGTTGGTTGAAGTGCCAGCGCAGCAACGGATTCGCAAAGTATTTTT
GTTACCCGCTGCCAATGTTT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MDVPLLYEIVTIFLLSIFVTVTCNKIKLPATVGFLLTGVLCGPSLLGIVSDREAIDHVAEIGVAMLLFTIGMELSGEALN
RLKRPVFLGGSLQIGLTVLAVMGLALLGGYSYQQGVFMGCLVALSSSAIVLRIMQERGSTNTPTGRLSLAILVFQDIMVA
PMLLCVPLLSGTLDLSLESAFFSTLWVVLALGGVLLFARFGLNRLMEAVVRTRTREILLLTTLGLCLGMALLTNTLGLSL
SLGAFMAGLLLARSQYSMSVIAGILPYRDVFMSLFFISVGMMLNVDFFGKHFFSIIGLTALFIVIKSLLTLPAVLVQGYP
LRAAIITSLSLAQVGEFAFVLAASGLSAGLFDMDAYQNFLDVSVLTMMLTPGLMTIAPRLADRFAGQRNSEQQEESGQQE
GEKRLEDHLIIVGFGISGKHLAHVAKESGIEYTILEMNPETVSRYRQKEPIAHGDASQPVVLEHLGVTRARVLVIVISDP
SAVRAITIEARRFNPNLHIIARTRFVTEVAALRRLGADEVIAEEFETSVEIFTRVLSQYLVPRQDIDTFAARIRQENYRM
IRRMSSAVDSLDSIVNRLPDMGVQAMRLGGASPLCGRSLAQTELRRRHGVTVIAILREGITHASPGADEIFEPGDIVYLF
GKTDKVIAITPLFSGPVRESARDGKGGMPQPARPTA

Sequences:

>Translated_676_residues
MDVPLLYEIVTIFLLSIFVTVTCNKIKLPATVGFLLTGVLCGPSLLGIVSDREAIDHVAEIGVAMLLFTIGMELSGEALN
RLKRPVFLGGSLQIGLTVLAVMGLALLGGYSYQQGVFMGCLVALSSSAIVLRIMQERGSTNTPTGRLSLAILVFQDIMVA
PMLLCVPLLSGTLDLSLESAFFSTLWVVLALGGVLLFARFGLNRLMEAVVRTRTREILLLTTLGLCLGMALLTNTLGLSL
SLGAFMAGLLLARSQYSMSVIAGILPYRDVFMSLFFISVGMMLNVDFFGKHFFSIIGLTALFIVIKSLLTLPAVLVQGYP
LRAAIITSLSLAQVGEFAFVLAASGLSAGLFDMDAYQNFLDVSVLTMMLTPGLMTIAPRLADRFAGQRNSEQQEESGQQE
GEKRLEDHLIIVGFGISGKHLAHVAKESGIEYTILEMNPETVSRYRQKEPIAHGDASQPVVLEHLGVTRARVLVIVISDP
SAVRAITIEARRFNPNLHIIARTRFVTEVAALRRLGADEVIAEEFETSVEIFTRVLSQYLVPRQDIDTFAARIRQENYRM
IRRMSSAVDSLDSIVNRLPDMGVQAMRLGGASPLCGRSLAQTELRRRHGVTVIAILREGITHASPGADEIFEPGDIVYLF
GKTDKVIAITPLFSGPVRESARDGKGGMPQPARPTA
>Mature_676_residues
MDVPLLYEIVTIFLLSIFVTVTCNKIKLPATVGFLLTGVLCGPSLLGIVSDREAIDHVAEIGVAMLLFTIGMELSGEALN
RLKRPVFLGGSLQIGLTVLAVMGLALLGGYSYQQGVFMGCLVALSSSAIVLRIMQERGSTNTPTGRLSLAILVFQDIMVA
PMLLCVPLLSGTLDLSLESAFFSTLWVVLALGGVLLFARFGLNRLMEAVVRTRTREILLLTTLGLCLGMALLTNTLGLSL
SLGAFMAGLLLARSQYSMSVIAGILPYRDVFMSLFFISVGMMLNVDFFGKHFFSIIGLTALFIVIKSLLTLPAVLVQGYP
LRAAIITSLSLAQVGEFAFVLAASGLSAGLFDMDAYQNFLDVSVLTMMLTPGLMTIAPRLADRFAGQRNSEQQEESGQQE
GEKRLEDHLIIVGFGISGKHLAHVAKESGIEYTILEMNPETVSRYRQKEPIAHGDASQPVVLEHLGVTRARVLVIVISDP
SAVRAITIEARRFNPNLHIIARTRFVTEVAALRRLGADEVIAEEFETSVEIFTRVLSQYLVPRQDIDTFAARIRQENYRM
IRRMSSAVDSLDSIVNRLPDMGVQAMRLGGASPLCGRSLAQTELRRRHGVTVIAILREGITHASPGADEIFEPGDIVYLF
GKTDKVIAITPLFSGPVRESARDGKGGMPQPARPTA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=381, Percent_Identity=27.8215223097113, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1789749, Length=545, Percent_Identity=31.1926605504587, Blast_Score=232, Evalue=7e-62,
Organism=Escherichia coli, GI1786232, Length=549, Percent_Identity=32.2404371584699, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786685, Length=540, Percent_Identity=29.2592592592593, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 73376; Mature: 73376

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVPLLYEIVTIFLLSIFVTVTCNKIKLPATVGFLLTGVLCGPSLLGIVSDREAIDHVAE
CCCCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHH
IGVAMLLFTIGMELSGEALNRLKRPVFLGGSLQIGLTVLAVMGLALLGGYSYQQGVFMGC
HHHHHHHHHHCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LVALSSSAIVLRIMQERGSTNTPTGRLSLAILVFQDIMVAPMLLCVPLLSGTLDLSLESA
HHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FFSTLWVVLALGGVLLFARFGLNRLMEAVVRTRTREILLLTTLGLCLGMALLTNTLGLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLGAFMAGLLLARSQYSMSVIAGILPYRDVFMSLFFISVGMMLNVDFFGKHFFSIIGLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIVIKSLLTLPAVLVQGYPLRAAIITSLSLAQVGEFAFVLAASGLSAGLFDMDAYQNFL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
DVSVLTMMLTPGLMTIAPRLADRFAGQRNSEQQEESGQQEGEKRLEDHLIIVGFGISGKH
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
LAHVAKESGIEYTILEMNPETVSRYRQKEPIAHGDASQPVVLEHLGVTRARVLVIVISDP
HHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEEEEECCC
SAVRAITIEARRFNPNLHIIARTRFVTEVAALRRLGADEVIAEEFETSVEIFTRVLSQYL
CCEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
VPRQDIDTFAARIRQENYRMIRRMSSAVDSLDSIVNRLPDMGVQAMRLGGASPLCGRSLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
QTELRRRHGVTVIAILREGITHASPGADEIFEPGDIVYLFGKTDKVIAITPLFSGPVRES
HHHHHHHCCCEEEEHHHHCCCCCCCCHHHCCCCCCEEEEECCCCCEEEEECCCCCCHHHC
ARDGKGGMPQPARPTA
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDVPLLYEIVTIFLLSIFVTVTCNKIKLPATVGFLLTGVLCGPSLLGIVSDREAIDHVAE
CCCCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHH
IGVAMLLFTIGMELSGEALNRLKRPVFLGGSLQIGLTVLAVMGLALLGGYSYQQGVFMGC
HHHHHHHHHHCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LVALSSSAIVLRIMQERGSTNTPTGRLSLAILVFQDIMVAPMLLCVPLLSGTLDLSLESA
HHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FFSTLWVVLALGGVLLFARFGLNRLMEAVVRTRTREILLLTTLGLCLGMALLTNTLGLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLGAFMAGLLLARSQYSMSVIAGILPYRDVFMSLFFISVGMMLNVDFFGKHFFSIIGLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIVIKSLLTLPAVLVQGYPLRAAIITSLSLAQVGEFAFVLAASGLSAGLFDMDAYQNFL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
DVSVLTMMLTPGLMTIAPRLADRFAGQRNSEQQEESGQQEGEKRLEDHLIIVGFGISGKH
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
LAHVAKESGIEYTILEMNPETVSRYRQKEPIAHGDASQPVVLEHLGVTRARVLVIVISDP
HHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEEEEECCC
SAVRAITIEARRFNPNLHIIARTRFVTEVAALRRLGADEVIAEEFETSVEIFTRVLSQYL
CCEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
VPRQDIDTFAARIRQENYRMIRRMSSAVDSLDSIVNRLPDMGVQAMRLGGASPLCGRSLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
QTELRRRHGVTVIAILREGITHASPGADEIFEPGDIVYLFGKTDKVIAITPLFSGPVRES
HHHHHHHCCCEEEEHHHHCCCCCCCCHHHCCCCCCEEEEECCCCCEEEEECCCCCCHHHC
ARDGKGGMPQPARPTA
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA