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The map label for this gene is cycA [H]

Identifier: 220904256

GI number: 220904256

Start: 1149243

End: 1150664

Strand: Reverse

Name: cycA [H]

Synonym: Ddes_0983

Alternate gene names: 220904256

Gene position: 1150664-1149243 (Counterclockwise)

Preceding gene: 220904257

Following gene: 220904253

Centisome position: 40.04

GC content: 54.78

Gene sequence:

>1422_bases
ATGAGTGACAAGCCCACCCCCCCCGTGGGACACGAAGATCCTCATACTCTCAAACGCGGCCTCAGCCAGAGACACATCCA
GCTTATTGCCATCGGCGGAGCCATCGGTACAGGCCTTTTCATGGGGTCCGGCAAAACCATCAACCTTGCCGGGCCTTCCA
TCATCTTTGTATACGCCATTATCGGGGCCTTTCTGTACCTTGTCATGCGGGCCATGGGAGAACTCCTTCTCTCAAACCTC
AAGTACAAATCCTTCACTGACATGGCGGAGGATATCGTTGGTCCCTGGGCCGGCTTTTTTGTAGGCTGGACCTACTGGTT
CTGCTGGATTGTTACCGGTACGGCAGACGTTATCGCCATTGCCTCCTACTTTCACTTCTGGTTCCCCACGCTTTCGGTAT
GGATACCTTCCATTCTCTTCGTCCTGCTGATCATGGCACTCAACCTTGTTTCAGTGAACCTTTTCGGTGAAATGGAATTC
TGGTTTGCCTCCATCAAGATCGTGGCCATCATGGCCATTATTTGTGCCGGAGCGGTTATGGTCATTACCGGCTTTACCTC
ATCCATATCAGGTGACGTGGCCGCAGTATCCAACCTGTGGGATCATGGAGGATGGTTCCCCAAGGGGATATTCGGCTTCT
TTGCGGGCTTTCAGATAGCCATGTTCGCCTTTGTGGGCATTGAGCTTATCGGAACCACAGCGGCGGAAGCCAAGGATCCC
GAAATCAACCTGCCCAAGGCCATCAACACCATTCCCTTCCGTATCGTATTCTTTTACGTGTTCGCCTTGGTGGCCATCAT
GTGCATCACGCCCTGGTCCGCCATTGACCCCGAAACAAGCCCGTTCGTTCACACCTTCGTAGCCGTGGGCATTCCTGCGG
CAGCCAGTATCGTCAACTTCGTGGTGCTGACATCGGCGGCCTCTTCCGCCAACAGCGGCATCTACTCCACCAGCCGCATG
CTTTACGGCCTGTCGCTGGCCGGGGTAGCTCCCAAGTCTTTCGGCAAGCTTTCTTCGCACCGGGTTCCTGCCAACGGCCT
GCTGTTCTCGTGCCTCTGCCTGCTGCTCGGCGCGTCCATGCTCATTATCATGCCCACCATTATGGCGGCCTTTACCGTCA
TGACAACCATCTCCGCCATTTGCTTCATCTTCGTATGGTCCATGATTCTTGTTTCGTACTACGTCTACCGCAAGAAGTAC
CCCGAGCGGCACGCAGCTTCCAAGTTCAAGCTGCCCGGCGGCGTGTTCTCCTGCTGGATATGCTGGATATTCTTCGCCAT
AGTGCTTGTCCTGCTGACCTTTGAAGCCGACACGCGCATGGCCATGCTCACCACACCCCTGTGGTTCGTGCTTCTCGGCA
TCAGCTATTACTTCAGCCACAAGAACCATGTCAGCAAGCGTCAGAACGGCGCCAACAACTAA

Upstream 100 bases:

>100_bases
CGCACAGGCCAATCCCGCACCGGAAAACAAACATTGCTATTCGTGCGGGGCAAGAGCGTAAACGCCCCACAGCACCAACA
AAAAACAGGGAGCACGTACC

Downstream 100 bases:

>100_bases
CAGTTCCGTGACAGACTCCATATAACAAAAGGCCCGGATATACCGGGCCTTTTGTTATATGCTTTCAGCGGTGGCAGGTC
ATGCCTCCGGCAGGGGATCA

Product: amino acid permease-associated protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSDKPTPPVGHEDPHTLKRGLSQRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYAIIGAFLYLVMRAMGELLLSNL
KYKSFTDMAEDIVGPWAGFFVGWTYWFCWIVTGTADVIAIASYFHFWFPTLSVWIPSILFVLLIMALNLVSVNLFGEMEF
WFASIKIVAIMAIICAGAVMVITGFTSSISGDVAAVSNLWDHGGWFPKGIFGFFAGFQIAMFAFVGIELIGTTAAEAKDP
EINLPKAINTIPFRIVFFYVFALVAIMCITPWSAIDPETSPFVHTFVAVGIPAAASIVNFVVLTSAASSANSGIYSTSRM
LYGLSLAGVAPKSFGKLSSHRVPANGLLFSCLCLLLGASMLIIMPTIMAAFTVMTTISAICFIFVWSMILVSYYVYRKKY
PERHAASKFKLPGGVFSCWICWIFFAIVLVLLTFEADTRMAMLTTPLWFVLLGISYYFSHKNHVSKRQNGANN

Sequences:

>Translated_473_residues
MSDKPTPPVGHEDPHTLKRGLSQRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYAIIGAFLYLVMRAMGELLLSNL
KYKSFTDMAEDIVGPWAGFFVGWTYWFCWIVTGTADVIAIASYFHFWFPTLSVWIPSILFVLLIMALNLVSVNLFGEMEF
WFASIKIVAIMAIICAGAVMVITGFTSSISGDVAAVSNLWDHGGWFPKGIFGFFAGFQIAMFAFVGIELIGTTAAEAKDP
EINLPKAINTIPFRIVFFYVFALVAIMCITPWSAIDPETSPFVHTFVAVGIPAAASIVNFVVLTSAASSANSGIYSTSRM
LYGLSLAGVAPKSFGKLSSHRVPANGLLFSCLCLLLGASMLIIMPTIMAAFTVMTTISAICFIFVWSMILVSYYVYRKKY
PERHAASKFKLPGGVFSCWICWIFFAIVLVLLTFEADTRMAMLTTPLWFVLLGISYYFSHKNHVSKRQNGANN
>Mature_472_residues
SDKPTPPVGHEDPHTLKRGLSQRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYAIIGAFLYLVMRAMGELLLSNLK
YKSFTDMAEDIVGPWAGFFVGWTYWFCWIVTGTADVIAIASYFHFWFPTLSVWIPSILFVLLIMALNLVSVNLFGEMEFW
FASIKIVAIMAIICAGAVMVITGFTSSISGDVAAVSNLWDHGGWFPKGIFGFFAGFQIAMFAFVGIELIGTTAAEAKDPE
INLPKAINTIPFRIVFFYVFALVAIMCITPWSAIDPETSPFVHTFVAVGIPAAASIVNFVVLTSAASSANSGIYSTSRML
YGLSLAGVAPKSFGKLSSHRVPANGLLFSCLCLLLGASMLIIMPTIMAAFTVMTTISAICFIFVWSMILVSYYVYRKKYP
ERHAASKFKLPGGVFSCWICWIFFAIVLVLLTFEADTRMAMLTTPLWFVLLGISYYFSHKNHVSKRQNGANN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=335, Percent_Identity=25.3731343283582, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790653, Length=471, Percent_Identity=62.4203821656051, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=39.2935982339956, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=41.8300653594771, Blast_Score=331, Evalue=7e-92,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=38.3408071748879, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=39.6751740139211, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=37.621359223301, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=32.0541760722348, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788480, Length=396, Percent_Identity=37.6262626262626, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI87081708, Length=462, Percent_Identity=32.6839826839827, Blast_Score=229, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17531343, Length=442, Percent_Identity=21.7194570135747, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=375, Percent_Identity=25.8666666666667, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=502, Percent_Identity=31.2749003984064, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324061, Length=437, Percent_Identity=32.0366132723112, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=455, Percent_Identity=30.5494505494506, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=31.2925170068027, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6319824, Length=419, Percent_Identity=27.2076372315036, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=29.426433915212, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320717, Length=418, Percent_Identity=27.2727272727273, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=417, Percent_Identity=27.5779376498801, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=27.8801843317972, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=449, Percent_Identity=27.3942093541203, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324059, Length=423, Percent_Identity=30.0236406619385, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=442, Percent_Identity=24.4343891402715, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=27.4881516587678, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=26.8292682926829, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320251, Length=400, Percent_Identity=25, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=423, Percent_Identity=28.3687943262411, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=24.3718592964824, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=463, Percent_Identity=23.5421166306695, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668806, Length=411, Percent_Identity=23.8442822384428, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356285, Length=411, Percent_Identity=23.8442822384428, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668802, Length=411, Percent_Identity=23.8442822384428, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51790; Mature: 51659

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPTPPVGHEDPHTLKRGLSQRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYAI
CCCCCCCCCCCCCHHHHHHCHHHCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHH
IGAFLYLVMRAMGELLLSNLKYKSFTDMAEDIVGPWAGFFVGWTYWFCWIVTGTADVIAI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ASYFHFWFPTLSVWIPSILFVLLIMALNLVSVNLFGEMEFWFASIKIVAIMAIICAGAVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VITGFTSSISGDVAAVSNLWDHGGWFPKGIFGFFAGFQIAMFAFVGIELIGTTAAEAKDP
HHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EINLPKAINTIPFRIVFFYVFALVAIMCITPWSAIDPETSPFVHTFVAVGIPAAASIVNF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
VVLTSAASSANSGIYSTSRMLYGLSLAGVAPKSFGKLSSHRVPANGLLFSCLCLLLGASM
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LIIMPTIMAAFTVMTTISAICFIFVWSMILVSYYVYRKKYPERHAASKFKLPGGVFSCWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
CWIFFAIVLVLLTFEADTRMAMLTTPLWFVLLGISYYFSHKNHVSKRQNGANN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDKPTPPVGHEDPHTLKRGLSQRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYAI
CCCCCCCCCCCCHHHHHHCHHHCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHH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HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]