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The map label for this gene is pyrD [H]

Identifier: 21910627

GI number: 21910627

Start: 1134116

End: 1135051

Strand: Direct

Name: pyrD [H]

Synonym: SpyM3_1091

Alternate gene names: 21910627

Gene position: 1134116-1135051 (Clockwise)

Preceding gene: 21910617

Following gene: 21910679

Centisome position: 59.67

GC content: 41.35

Gene sequence:

>936_bases
ATGGTTTCTACTGCTACACAAATTGGTCATTTCTCTTTTGATAACTGTTTGATGAATGCTGCTGGTGTTTACTGCATGAC
AAAAGAAGAGCTTATGGAGGTTGAAAAGTCTCAAGCCGCTTCCTTTGTCACCAAAACAGGGACGCTTGAAGTTCGTCCAG
GTAATCCAGAACCTCGCTACGCAGATACTCGTCTTGGTTCTATCAATTCAATGGGACTCCCTAATAATGGTTTTCGCTAC
TACTTAGACTTTGTCAGTGATCTTGCCAAAACCGGGCAACATAAACCTCATTTTCTCTCCGTTGTCGGGCTATCTCCTAC
TGAAACCGAAACCATTCTAAAAGTCATCATGGCTTCAGATTATGAGGGTCTAGTGGAACTAAACCTTTCTTGCCCGAACG
TTCCAGGAAAACCACAGATTGCTTATGATTTTGAAACCACTGATCAACTTCTAGAGAACATCTTTACCTATTACACTAAA
CCTCTTGGTATCAAATTACCTCCTTATTTTGACATTGTGCATTTTGATCAAGCGGCTGCGATTTTCAATAAATACCCCCT
TTCCTTTGTTAACTGTGTCAATTCTATCGGAAATGGGCTGGTCATTGAGGATGAGCAAGTCCTCATAAAGCCTAAAAATG
GCTTTGGTGGTATAGGTGGAGATTACATCAAACCTACTGCTCTAGCCAATGTCCATGCGTTTTACAAACGCTTAAAACCT
TCTATCCACATTATTGGTACAGGGGGAATTAAAACAGGACGCGATGCCTTTGAACATATTCTTTGTGGCGCCAGCATGGT
CCAAATTGGGACAGCCCTTCATCAAGAAGGGCCAGCTATCTTTGAACGGGTCACTAAGGAACTAAAAACGATTATGGTAG
AAAAAGGCTATCAAAGCTTAGACGATTTTCGTGGGAACTTACGTTACAAAGATTAA

Upstream 100 bases:

>100_bases
TCAATAACAGTAATATATTTACATTTTTGTAAAAATAGCTTGCTATTATTCATGCCTAGTGGTAGAATAGAAAAAATTTG
TCTAAAATATGGAGGAAATA

Downstream 100 bases:

>100_bases
CCTTAATAGTCAAAAAAGCTTGGAAATGTGCACTTTGTACACTTTCCAAGCTTTTTAAAATGGGAATTTTTTTGAAGGGA
CAGCGTCACTTTCTTGGGAC

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKVIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGIKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Sequences:

>Translated_311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKVIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGIKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD
>Mature_311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKVIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGIKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082059, Length=218, Percent_Identity=26.605504587156, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=309, Percent_Identity=58.8996763754045, Blast_Score=381, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281361352, Length=287, Percent_Identity=27.8745644599303, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137316, Length=287, Percent_Identity=27.8745644599303, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 34366; Mature: 34366

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRY
CCCCCHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCC
ADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKVIMASD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFDQAAA
CCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHH
IFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SIHIIGTGGIKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSL
CEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHH
DDFRGNLRYKD
HHHCCCCCCCC
>Mature Secondary Structure
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRY
CCCCCHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCC
ADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKVIMASD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFDQAAA
CCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHH
IFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SIHIIGTGGIKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSL
CEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHH
DDFRGNLRYKD
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]