| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is glmS [H]
Identifier: 21910446
GI number: 21910446
Start: 965519
End: 967282
Strand: Reverse
Name: glmS [H]
Synonym: SpyM3_0910
Alternate gene names: 21910446
Gene position: 967282-965519 (Counterclockwise)
Preceding gene: 21910447
Following gene: 21910445
Centisome position: 50.9
GC content: 41.21
Gene sequence:
>1764_bases ATGCAAGGCCTTGAAAAGCTTGAATACCGGGGTTATGATTCAGCAGGAATTTTTGTGGCTAATGCCAATCAAACAAACTT GATTAAATCAGTGGGGCGGATTGCTGATTTGCGTGCCAAGATTGGCATTGATGTTGCTGGTTCAACAGGGATTGGTCACA CCCGTTGGGCAACGCATGGCCAATCAACAGAGGATAATGCCCATCCTCACACGTCACAAACTGGACGTTTTGTACTTGTT CATAATGGTGTGATTGAAAATTACCTTCACATTAAAACAGAGTTCCTAGCTGGACATGATTTTAAGGGGCAGACAGATAC TGAGATTGCAGTACACTTGATTGGAAAATTTGTGGAAGAAGACAAGTTGTCAGTACTGGAAGCTTTTAAAAAAGCTTTAA GCATTATTGAAGGTTCCTATGCCTTTGCGTTAATGGATAGCCAAGCAACTGATACTATTTATGTGGCTAAAAACAAATCT CCATTGTTGATTGGACTTGGTGAAGGTTACAACATGGTTTGTTCAGATGCCATGGCCATGATTCGTGAAACCAGTGAATT TATGGAAATTCATGATAAGGAGCTAGTTATTTTAACCAAAGATAAGGTAACTGTTACAGACTACGATGGTAAAGAGCTGA TACGAGATTCCTACACTGCTGAATTAGACTTATCTGATATTGGCAAAGGGACTTATCCTTTCTATATGCTGAAAGAAATT GATGAGCAACCAACCGTAATGCGTCAATTAATTTCAACTTATGCAGATGAAACTGGTAACGTACAGGTTGATCCAGCTAT CATTACCTCTATCCAAGAGGCTGACCGTCTTTATATTTTAGCGGCAGGGACTTCCTACCATGCTGGTTTTGCAACAAAAA ATATGCTTGAGCAATTGACAGATACACCAGTTGAGTTGGGAGTGGCTTCTGAGTGGGGTTACCACATGCCTCTGCTTAGC AAGAAACCAATGTTTATTCTACTAAGCCAATCAGGAGAAACCGCAGATAGTCGTCAAGTTTTAGTAAAGGCAAATGCTAT GGGCATTCCGAGTTTGACAGTAACTAACGTTCCAGGATCAACCTTATCACGTGAATCAACATACACCATGTTGATTCATG CTGGACCTGAAATTGCTGTTGCATCTACAAAAGCTTACACTGCACAAATTGCTGCCCTTGCCTTTTTGGCTAAGGCAGTT GGTGAGGCAAATGGTAAGCAAGAAGCTCTTGACTTTAACTTGGTACATGAGTTGTCATTGGTTGCCCAATCTATTGAGGC GACTTTGTCTGAAAAAGATCTCGTGGCAGAAAAGGTTCAAGCTTTGCTAACTACTACTCGTAATGCTTTTTACATCGGGC GTGGCAATGATTATTACGTTGCGATGGAAGCTGCTTTGAAATTAAAAGAGATTTCTTATATTCAATGCGAAGGCTTTGCG GCTGGTGAATTGAAACATGGAACCATTTCATTAATTGAGGAGGACACGCCAGTAATCGCTTTAATATCGTCTAGTCAGTT GGTTGCCTCTCATACGCGTGGTAATATTCAAGAAGTTGCTGCCCGTGGGGCTCATGTTTTAACAGTTGTGGAAGAAGGGC TTGACCGTGAGGGAGATGACATTATTGTCAATAAGGTTCATCCTTTCCTAGCCCCGATTGCTATGGTCATTCCAACTCAA CTGATTGCTTACTACGCTTCATTACAACGTGGACTTGATGTTGATAAGCCACGTAATTTGGCTAAAGCTGTAACAGTAGA ATAA
Upstream 100 bases:
>100_bases AAATTATGAGAGAAAGTAGCAAGTTAACGAACTTGTTAAGGTAATTAAGATGTGTGGAATTGTTGGAGTTGTTGGAAATC GCAATGCAACGGATATTTTA
Downstream 100 bases:
>100_bases ATGATTATAATGGATAAGGCAACCATCTGTTAGGTGGTTGCTTTTTGTTTTTAGGAGAATAGCAGAGCTTAGAAAATGGC CTTGAGAAAAGCTATACAAG
Product: glucosamine--fructose-6-phosphate aminotransferase
Products: NA
Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]
Number of amino acids: Translated: 587; Mature: 587
Protein sequence:
>587_residues MQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLV HNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKS PLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEI DEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLS KKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAV GEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFA AGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQ LIAYYASLQRGLDVDKPRNLAKAVTVE
Sequences:
>Translated_587_residues MQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLV HNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKS PLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEI DEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLS KKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAV GEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFA AGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQ LIAYYASLQRGLDVDKPRNLAKAVTVE >Mature_587_residues MQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLV HNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKS PLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEI DEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLS KKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAV GEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFA AGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQ LIAYYASLQRGLDVDKPRNLAKAVTVE
Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]
COG id: COG0449
COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 SIS domains [H]
Homologues:
Organism=Homo sapiens, GI205277386, Length=674, Percent_Identity=33.2344213649852, Blast_Score=304, Evalue=2e-82, Organism=Homo sapiens, GI4826742, Length=673, Percent_Identity=31.9465081723626, Blast_Score=290, Evalue=3e-78, Organism=Escherichia coli, GI1790167, Length=603, Percent_Identity=38.1426202321725, Blast_Score=395, Evalue=1e-111, Organism=Caenorhabditis elegans, GI17539970, Length=426, Percent_Identity=31.924882629108, Blast_Score=209, Evalue=3e-54, Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=32.8703703703704, Blast_Score=207, Evalue=2e-53, Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=32.8703703703704, Blast_Score=206, Evalue=3e-53, Organism=Saccharomyces cerevisiae, GI6322745, Length=476, Percent_Identity=31.3025210084034, Blast_Score=216, Evalue=8e-57, Organism=Saccharomyces cerevisiae, GI6323731, Length=413, Percent_Identity=27.1186440677966, Blast_Score=149, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6323730, Length=182, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI21357745, Length=670, Percent_Identity=31.044776119403, Blast_Score=295, Evalue=9e-80,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000583 - InterPro: IPR017932 - InterPro: IPR005855 - InterPro: IPR001347 [H]
Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]
EC number: =2.6.1.16 [H]
Molecular weight: Translated: 63910; Mature: 63910
Theoretical pI: Translated: 4.88; Mature: 4.88
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHG CCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEECCCC QSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEE CCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHH DKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAM HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHH IRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEI HHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEEHHHCCCCCCCCHHHHHC DEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLT CCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHC DTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGS CCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEEECCCCC TLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSL CCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH VAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFA HHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHHHHCCEEEECCEE AGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDD CCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCCCEEEEEEHHCCCCCCCE IIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECC >Mature Secondary Structure MQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHG CCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEECCCC QSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEE CCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHH DKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAM HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHH IRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEI HHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEEHHHCCCCCCCCHHHHHC DEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLT CCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHC DTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGS CCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEEECCCCC TLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSL CCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH VAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFA HHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHHHHCCEEEECCEE AGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDD CCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCCCEEEEEEHHCCCCCCCE IIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11296296 [H]