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The map label for this gene is fhs.1

Identifier: 21910389

GI number: 21910389

Start: 909731

End: 911401

Strand: Reverse

Name: fhs.1

Synonym: SpyM3_0853

Alternate gene names: 21910389

Gene position: 911401-909731 (Counterclockwise)

Preceding gene: 21910390

Following gene: 21910388

Centisome position: 47.96

GC content: 42.73

Gene sequence:

>1671_bases
ATGAAATCAGATATCGAAATTGCCCAAAGTGTCGCCCTACAACCAATCACTGACATTGTTAAAAAAGTTGGAATAGACGG
CGATGACATTGAGCTTTATGGCAAATATAAGGCTAAATTGTCTTTTGAGAAAATGAAAGCTGTCGAAGCTAATGAGCCTG
GAAAATTAATCTTGGTAACTGCTATTAACCCTACTCCAGCGGGAGAAGGAAAATCAACCATGTCTATTGGACTGGCAGAT
GCCTTAAATCAAATGGGAAAAAAAACCATGCTTGCCTTACGTGAACCCTCCCTTGGTCCTGTTATGGGGATTAAAGGCGG
GGCAGCAGGTGGTGGTTATGCCCAAGTATTGCCTATGGAAGACATTAATCTTCACTTTACTGGTGACATGCATGCCATTA
CAACTGCTAATAATGCATTATCTGCTTTGATTGACAATCATTTGCAGCAAGGAAACGATTTAGGAATTGATCCTCGCCGC
ATTATTTGGAAGCGCGTGTTGGACCTTAATGATCGCGCTCTTCGTCAGGTAATTGTTGGCTTAGGTAGTCCAGTGAATGG
TGTGCCACGCGAAGATGGGTTTGATATCACAGTAGCTTCTGAAATCATGGCAATTTTATGTTTGGCAACTGACTTAAAAG
ATCTAAAGAAACGTCTTGCTGATATCGTCGTGGCTTATACCTATGATCGTAAGCCTGTCTATGTGCGTGACTTGAAGGTT
GAAGGAGCATTGACATTAATTCTAAAAGATGCTATCAAGCCAAACTTGGTGCAGACTATTTATGGAACACCAGCTCTTAT
TCATGGGGGGCCATTTGCTAATATTGCTCATGGTTGTAATTCTGTCCTTGCTACCTCAACAGCTTTGCGATTAGCAGATT
ACACTGTTACCGAAGCAGGATTCGGGGCCGACCTAGGAGCTGAAAAATTCCTAAATATCAAAGTACCTAATCTTCCTAAA
GCACCAGATGCTATCGTCATTGTTGCAACCTTGCGCGCCCTTAAAATGCATGGAGGTGTCGCCAAATCAGATTTAGCCGC
TGAAAATTGTGAGGCTGTTCGCTTAGGATTTGCCAACTTAAAACGTCACGTGGAAAACATGCGCCAATTCAAAGTTCCAG
TTGTGGTGGCTATCAATGAATTTGTAGCAGATACCGAGGCTGAAATTGCTACCTTAAAAGCGCTTTGTGAAGAGATTAAG
GTTCCAGTAGAATTAGCCAGTGTTTGGGCAAATGGAGCTGAGGGAGGCTTAGCATTAGCTAAAACAGTGGTTCGTGTGAT
TGATCAAGAAGCTGCTGACTACAAACGTCTCTATTCAGATGAGGATACTTTGGAAGAAAAAGTGATCAATATCGTTACCC
AGATTTATGGTGGCAAAGCTGTTCAATTTGGCCCCAAGGCCAAAACACAATTGAAGCAGTTCGCAGAATTCGGTTGGGAT
AAATTGCCTGTTTGTATGGCTAAGACCCAATACAGTTTTTCAGATAACCCATCCTTGCTTGGAGCGCCAACCGATTTTGA
CATTACCATTCGTGAATTTGTTCCTAAAACAGGAGCAGGTTTTATTGTTGGTTTAACAGGTGATGTGATGACCATGCCTG
GTTTGCCTAAAGTTCCAGCTGCCATGGCAATGGACGTAGCAGAAAATGGCACAGCCCTCGGTCTCTTTTAG

Upstream 100 bases:

>100_bases
TGCGATTAAAAACGAACAATAATTGTTTTAATTCAAATAAATGTACGCATGATATGAATTGTGATATAATGACGTCATTA
CGTAAAATTGAGGAGTCATC

Downstream 100 bases:

>100_bases
GAAAAATTGCTCGAATAATTCGAGCAAGCGCTCCTTTCTTCCCGCTTTACTGTGATATAATAAGGTAAATGAGATTTTGG
AGGGATGATTATCAAAAAGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase 1; FHS 1; FTHFS 1

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLILVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTVVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF

Sequences:

>Translated_556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLILVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTVVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF
>Mature_556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLILVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTVVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=41.9354838709677, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=41.4790996784566, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI310124614, Length=82, Percent_Identity=36.5853658536585, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=608, Percent_Identity=41.4473684210526, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17568739, Length=608, Percent_Identity=41.4473684210526, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.1725239616613, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=40.095087163233, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=40.8723747980614, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=40.8723747980614, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=40.8723747980614, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=40.8723747980614, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS1_STRP1 (Q99ZI9)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269351.1
- RefSeq:   YP_282290.1
- ProteinModelPortal:   Q99ZI9
- SMR:   Q99ZI9
- EnsemblBacteria:   EBSTRT00000000078
- EnsemblBacteria:   EBSTRT00000028171
- GeneID:   3571980
- GeneID:   901317
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1213
- KEGG:   spz:M5005_Spy_0927
- GeneTree:   EBGT00050000027107
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   SPYO160490:SPY1213-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0927-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59532; Mature: 59532

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLILVT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEHHHHHHHHHCHHHEEEECCCCCCCEECCCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRRIIWKRVLDLNDRALRQVIVG
CCEEEECCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCCEEEEEHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
KRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIKVPVELASVWANGAEGGLALA
HHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHH
KTVVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCC
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPA
CCCCEEEECCCCCCCCCCEECCCCCCCEEHHHHCCCCCCCEEEEECCCEEECCCCCCCCH
AMAMDVAENGTALGLF
HHHHHHHCCCCEECCC
>Mature Secondary Structure
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLILVT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEHHHHHHHHHCHHHEEEECCCCCCCEECCCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRRIIWKRVLDLNDRALRQVIVG
CCEEEECCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCCEEEEEHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
KRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIKVPVELASVWANGAEGGLALA
HHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHH
KTVVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCC
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPA
CCCCEEEECCCCCCCCCCEECCCCCCCEEHHHHCCCCCCCEEEEECCCEEECCCCCCCCH
AMAMDVAENGTALGLF
HHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296