Definition Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession NC_004070
Length 1,900,521

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The map label for this gene is ldh [H]

Identifier: 21910345

GI number: 21910345

Start: 861606

End: 862589

Strand: Reverse

Name: ldh [H]

Synonym: SpyM3_0809

Alternate gene names: 21910345

Gene position: 862589-861606 (Counterclockwise)

Preceding gene: 21910350

Following gene: 21910333

Centisome position: 45.39

GC content: 40.85

Gene sequence:

>984_bases
ATGACTGCAACTAAACAACACAAAAAAGTAATCTTGGTCGGTGATGGTGCCGTCGGTTCATCATACGCTTTTGCATTGGT
AACACAAAATATTGCTCAAGAACTTGGTATTATTGATATTTTTAAAGAAAAAACTCAAGGAGATGCAGAAGATTTAAGCC
ACGCTCTAGCTTTTACATCACCTAAAAAAATCTATGCAGCTGACTACTCAGACTGTCATGATGCTGATCTTGTTGTCTTA
ACAGCTGGTGCTCCTCAAAAACCAGGTGAAACACGCCTTGACCTTGTTGAAAAAAACCTTCGTATCAATAAAGAGGTTGT
TACACAAATCGTTGCATCTGGTTTCAAAGGAATCTTTCTTGTTGCTGCTAACCCAGTTGACGTTTTGACTTACTCAACAT
GGAAATTCTCAGGTTTCCCTAAAGAGCGTGTCATTGGTTCAGGTACATCTCTAGATTCAGCCCGTTTCCGTCAAGCTCTG
GCTGCTAAAATCGGTGTTGATGCGCGTTCGGTTCACGCTTACATCATGGGAGAACACGGTGACTCTGAATTTGCTGTTTG
GTCACACGCTAACGTTGCTGGTGTAGGTCTTTACGACTGGCTCCAAGCTAATCGTGACATTGATGAGCAAGGCCTAGTTG
ATCTTTTCATTTCTGTACGTGATGCTGCTTACTCAATCATCAATAAAAAAGGTGCTACTTTCTACGGTATTGCAGTTGCC
CTAGCTCGTATTACAAAAGCTATTCTTGATGATGAAAATGCTGTTCTTCCGCTTTCTGTTTTCCAAGAAGGCCAATACGA
AGGTGTTGAAGATTGCTATATTGGTCAACCAGCTATCGTTGGAGCGTATGGAATTGTTCGTCCAGTAAACATTCCACTTA
ACGATGCTGAATTGCAAAAAATGCAAGCCTCTGCAAATCAATTGAAAGCTATCATTGATGAAGCCTTTGCTAAGGAAGAA
TTTGCTTCTGCTGCTAAAAACTAA

Upstream 100 bases:

>100_bases
TTTTCATTATTTTTCTGAATTCAATGACAAACAATTATCAATATGTTAAAATAAGACCGTATGAGCTTTTGCTCTAATAA
AATTAAGGAGATGTTTAGAA

Downstream 100 bases:

>100_bases
TCACAAAAGAGACTTCGGTCTCTTTTTGTTTTGCCTGATATTCCTTTTCCAACGTGCTATAAGAGGATAATCATAAGTTT
AGAACTTTTCAGGTTGCAAC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVL
TAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQAL
AAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEE
FASAAKN

Sequences:

>Translated_327_residues
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVL
TAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQAL
AAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEE
FASAAKN
>Mature_326_residues
TATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVLT
AGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALA
AKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVAL
ARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEEF
ASAAKN

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI291575128, Length=308, Percent_Identity=38.6363636363636, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557032, Length=308, Percent_Identity=38.6363636363636, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI47059044, Length=314, Percent_Identity=38.8535031847134, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI221136809, Length=314, Percent_Identity=38.8535031847134, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=37.9421221864952, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI5031857, Length=311, Percent_Identity=37.9421221864952, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI260099723, Length=311, Percent_Identity=37.9421221864952, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI9257228, Length=302, Percent_Identity=39.4039735099338, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504973, Length=302, Percent_Identity=39.4039735099338, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI260099727, Length=192, Percent_Identity=44.7916666666667, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI260099725, Length=192, Percent_Identity=44.7916666666667, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI207028494, Length=196, Percent_Identity=38.7755102040816, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI103472011, Length=308, Percent_Identity=24.025974025974, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI103472015, Length=184, Percent_Identity=29.3478260869565, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21735621, Length=338, Percent_Identity=25.4437869822485, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=42.4657534246575, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17554310, Length=260, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136226, Length=302, Percent_Identity=38.0794701986755, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI45550422, Length=316, Percent_Identity=31.0126582278481, Blast_Score=160, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24647881, Length=331, Percent_Identity=26.8882175226586, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35272; Mature: 35141

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCC
PKKIYAADYSDCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFL
CCEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHG
EECCCCCEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEECCC
DSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
CCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQK
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCHHCCCCCHHEECCCCEEECCCCCCHHHHHH
MQASANQLKAIIDEAFAKEEFASAAKN
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTS
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCC
PKKIYAADYSDCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFL
CCEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHG
EECCCCCEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEECCC
DSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
CCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQK
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCHHCCCCCHHEECCCCEEECCCCCCHHHHHH
MQASANQLKAIIDEAFAKEEFASAAKN
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA