Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
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Accession | NC_004070 |
Length | 1,900,521 |
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The map label for this gene is malK [H]
Identifier: 21910305
GI number: 21910305
Start: 821650
End: 823191
Strand: Reverse
Name: malK [H]
Synonym: SpyM3_0769
Alternate gene names: 21910305
Gene position: 823191-821650 (Counterclockwise)
Preceding gene: 21910308
Following gene: 21910304
Centisome position: 43.31
GC content: 39.23
Gene sequence:
>1542_bases ATGAAAAAACCACTACGTTTATGGGCCAGTTTATCGTTGATTTTGGTATCTATGATTGTTGTCACAACCTCCCTATTTTA CGGGATTATGCTACATGATACGCACCAATCCATCAAAAATCAGGAAACCCATTTGCTAACGTCAACTGGAAAAATGTTAG CAAGTCATCAAGCAATTAAAGAATTACTCCTAAACAACCAACCAAATGCTAAAACAACAGCCTATACCAACTCCATTGCC TCCATCTATAACCTTGATTATGTGGTCGTGATGAACATGAAAGGGATTCGACTCACCCATCCTAACCCGAAAAATATCGG AAAACCTTTTCAAGGAGGTGATGAGGAGGCTGTTCTAGCAGGAAAAAAGGTTATCTCTACCGCCAAGGGTACTTTAGGAA AGTCACTTCGCTATCTAGTACCTGTGTTTGACGGTGACAAACAGATTGGTGCTATTGCGGTTGGCATTAAACTAACTACC CTAAATGATGTGGCTTTAACGTCAAAACGCAATTATACCCTGTCTTTACTCCTTTGTCTTCTTATTAGTTTACTGGTCAC CAGTTTTATTTCTTTTCGACTCAAGCGTCAACTGCACCAGTTAGAACCAAGTGAAATTTACCAGCTCTTTGAAGAGCGTA ATGCCATGTTGGATCAAATCGAAGCCGCCGTATTTGTGGTAGATAAAGCTGGTATCTTACAGCTCTGCAATCAGGCTGGA CAAAAATTAATTGCTCGGAAATGCCAGTTGGGAAAACCTACTGGCAACAGTTTCAATCACCTCTTTCCTGATTTTCCAAA ACTTAGTTTGCAAGAGGGGCATGAACAACTCTTTCGGTATGGTGAGGAAGACTACTTGTTAGCCATTTCACCCATCTGTG TCAAAAACGATCACCGAGGCCACATTATTTTCATACGAGAAGCAGTTAAGGCTATTGATACCTTGGATCAGCTAGCCTAT ACCACTGCCTATGCTTCTGCTCTACAAGCCCAAACTCATAAATTCATGAATCAATTGCATGTTATTTATGGCTTAGTGGA TATTACTTATTATGACCAATTGAAAATTTATTTAGACAGTATTTTGGAACCCGAAAATGAAATTCTCACTAGCTTATCTG TCCTTGTTAAGGAGCCTCTTCTAGCTAGTTTTCTCATTGGAGAGCAAGAGAAATACCAAGAATTAAATGTCCATCTCAAG ATTGATGTTTTAAGCGAGATTCCTCATTCTGCCACCAAGAATCAACTTAATAATGGTTTGATGATTTACCGCTTTATCCA TACTAATCTTCTAACCACACTGAGACCCAAATCACTCGTTTTGAGTATTCAACATGATCAGAATCATTTAATCAGCCATT ACACCTTGACAGACAATTGGATTGATTTGGAGCGGGTACAGCCTATTTTTGACTTACCTTATTTTCAACAGCTCTTGACC GATACAAATTCCCAATTCCATCAACATCAAACCGTAACCGAGTTACAGTTCTCAGTGACAACACCTTATGTAGGAGGGCA ACATGAACGTTTTAATCATTGA
Upstream 100 bases:
>100_bases ATTTAAGTTGTTTAACTACTTTAATTTTTTCAAGTTATTTAATTAATTTAAGCTAGCAGGTCATTTCTTATCGTGTTATA CTCAATAAAGAGGAGACTTT
Downstream 100 bases:
>100_bases AGATGATCCCATGGTGGATTTTATCCATCGCAATTACCTCGAAAAACTAAATCTTTTTGATCGCATTATATCCAGCGACT CTATGAAAGCTGTTCAAAGC
Product: putative two-component sensor histidine kinase
Products: NA
Alternate protein names: Malate kinase sensor [H]
Number of amino acids: Translated: 513; Mature: 513
Protein sequence:
>513_residues MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTGKMLASHQAIKELLLNNQPNAKTTAYTNSIA SIYNLDYVVVMNMKGIRLTHPNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTT LNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAG QKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRGHIIFIREAVKAIDTLDQLAY TTAYASALQAQTHKFMNQLHVIYGLVDITYYDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK IDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHLISHYTLTDNWIDLERVQPIFDLPYFQQLLT DTNSQFHQHQTVTELQFSVTTPYVGGQHERFNH
Sequences:
>Translated_513_residues MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTGKMLASHQAIKELLLNNQPNAKTTAYTNSIA SIYNLDYVVVMNMKGIRLTHPNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTT LNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAG QKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRGHIIFIREAVKAIDTLDQLAY TTAYASALQAQTHKFMNQLHVIYGLVDITYYDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK IDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHLISHYTLTDNWIDLERVQPIFDLPYFQQLLT DTNSQFHQHQTVTELQFSVTTPYVGGQHERFNH >Mature_513_residues MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTGKMLASHQAIKELLLNNQPNAKTTAYTNSIA SIYNLDYVVVMNMKGIRLTHPNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTT LNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAG QKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRGHIIFIREAVKAIDTLDQLAY TTAYASALQAQTHKFMNQLHVIYGLVDITYYDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK IDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHLISHYTLTDNWIDLERVQPIFDLPYFQQLLT DTNSQFHQHQTVTELQFSVTTPYVGGQHERFNH
Specific function: Member of a two-component regulatory system malK/malR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates malR by phosphorylation [H]
COG id: COG3290
COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]
Homologues:
Organism=Escherichia coli, GI1790567, Length=449, Percent_Identity=28.0623608017817, Blast_Score=174, Evalue=1e-44, Organism=Escherichia coli, GI1786837, Length=467, Percent_Identity=22.2698072805139, Blast_Score=110, Evalue=3e-25,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR000014 - InterPro: IPR013767 - InterPro: IPR004358 - InterPro: IPR016120 - InterPro: IPR005467 - InterPro: IPR016121 [H]
Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]
EC number: =2.7.13.3 [H]
Molecular weight: Translated: 58144; Mature: 58144
Theoretical pI: Translated: 7.60; Mature: 7.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTGKMLASHQAIK CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHCCCCCEEEEHHHHHHHHHHHHH ELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTHPNPKNIGKPFQGGDEEAVLA HHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCHHHHH GKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTTLNDVALTSKRNYTLSLLLCL HHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCEEECCCCCHHHHHHHHH LISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAG HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHH QKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRG HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCEEEECCCCC HIIFIREAVKAIDTLDQLAYTTAYASALQAQTHKFMNQLHVIYGLVDITYYDQLKIYLDS CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLKIDVLSEIPHSATKNQLNNGL HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEEEEHHHCCCHHHHHHCCCCE MIYRFIHTNLLTTLRPKSLVLSIQHDQNHLISHYTLTDNWIDLERVQPIFDLPYFQQLLT EEEEEHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCEEHHHCCHHHCCHHHHHHHH DTNSQFHQHQTVTELQFSVTTPYVGGQHERFNH CCCHHHHHHHHHHHEEEEEECCCCCCCCCCCCC >Mature Secondary Structure MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTGKMLASHQAIK CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHCCCCCEEEEHHHHHHHHHHHHH ELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTHPNPKNIGKPFQGGDEEAVLA HHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCHHHHH GKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTTLNDVALTSKRNYTLSLLLCL HHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCEEECCCCCHHHHHHHHH LISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAG HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHH QKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRG HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCEEEECCCCC HIIFIREAVKAIDTLDQLAYTTAYASALQAQTHKFMNQLHVIYGLVDITYYDQLKIYLDS CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLKIDVLSEIPHSATKNQLNNGL HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEEEEHHHCCCHHHHHHCCCCE MIYRFIHTNLLTTLRPKSLVLSIQHDQNHLISHYTLTDNWIDLERVQPIFDLPYFQQLLT EEEEEHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCEEHHHCCHHHCCHHHHHHHH DTNSQFHQHQTVTELQFSVTTPYVGGQHERFNH CCCHHHHHHHHHHHEEEEEECCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9274030; 9384377; 12949159; 12949160 [H]