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The map label for this gene is folK [H]

Identifier: 21910298

GI number: 21910298

Start: 815595

End: 816083

Strand: Direct

Name: folK [H]

Synonym: SpyM3_0762

Alternate gene names: 21910298

Gene position: 815595-816083 (Clockwise)

Preceding gene: 21910297

Following gene: 21910299

Centisome position: 42.91

GC content: 39.88

Gene sequence:

>489_bases
ATGACCATTGTTTATTTAAGTTTAGGCACCAATATGGGGGACCGAGCAGCTTACTTGCAAAAAGCTCTTGAGGCTTTAGC
TGACTTACCTCAAACACGGTTGCTTGCTCAATCATCCATTTATGAAACGACTGCTTGGGGCAAGACAAGCCAGGCTGATT
TTCTCAATATGGCCTATCAATTAGATACACAATTAACCGCGGCTGATTTCTTAAAAGAAACACAAGCTATTGAGCAATCT
CTTGGTCGTGTGAGGCATGAAAAATGGGGATCAAGAACTATTGATATTGACATCCTGCTATTTGGAGAAGAGGTTTATGA
CACAAAGGAATTGAAAGTGCCACACCCTTATATGACTGAGCGTGCTTTTGTTTTAATCCCCTTATTGGAATTGCAGCCAG
ATTTAAAATTGCCTCCTAATCATAAGCTTTTAAGGGATTATCTTGCAGCTTTAGATCAATCAGATATCACGCTCTTTTCA
GCTCAATAG

Upstream 100 bases:

>100_bases
AATTTCCACCTATTGAAGCCATCAAAGTGGCCATTAAAAAGGAAAACCCACCGATTGCAGGCCACTATAAGGCAGTTGGT
ATTGAATTGGAGAGACAGAG

Downstream 100 bases:

>100_bases
ACAGAGTTCTAGACTCTGTTTTCGGAGTAATGCCTGCTATAAGCCAATCCATAAAGTTTTGCCAAATTCATCGTTATTTT
TTCTAAAATTTGATATAATA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTSQADFLNMAYQLDTQLTAADFLKETQAIEQS
LGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTERAFVLIPLLELQPDLKLPPNHKLLRDYLAALDQSDITLFS
AQ

Sequences:

>Translated_162_residues
MTIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTSQADFLNMAYQLDTQLTAADFLKETQAIEQS
LGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTERAFVLIPLLELQPDLKLPPNHKLLRDYLAALDQSDITLFS
AQ
>Mature_161_residues
TIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTSQADFLNMAYQLDTQLTAADFLKETQAIEQSL
GRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTERAFVLIPLLELQPDLKLPPNHKLLRDYLAALDQSDITLFSA
Q

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=149, Percent_Identity=43.6241610738255, Blast_Score=127, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324073, Length=141, Percent_Identity=39.0070921985816, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18374; Mature: 18243

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTSQADFLNMAYQ
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LDTQLTAADFLKETQAIEQSLGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHCCCCCCCCCCCHHC
RAFVLIPLLELQPDLKLPPNHKLLRDYLAALDQSDITLFSAQ
CCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
TIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTSQADFLNMAYQ
EEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LDTQLTAADFLKETQAIEQSLGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHCCCCCCCCCCCHHC
RAFVLIPLLELQPDLKLPPNHKLLRDYLAALDQSDITLFSAQ
CCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]