BacMap

Definition	Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession	NC_004070
Length	1,900,521

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The map label for this gene is cypB [C]

Identifier: 21909857

GI number: 21909857

Start: 361557

End: 362363

Strand: Reverse

Name: cypB [C]

Synonym: SpyM3_0321

Alternate gene names: 21909857

Gene position: 362363-361557 (Counterclockwise)

Preceding gene: 21909859

Following gene: 21909853

Centisome position: 19.07

GC content: 39.41

Gene sequence:

>807_bases
ATGAAAAAATTATTATCTCTCAGTTTAGTAGCCATTAGTTTACTTAGTTTGAGTGCTTGTGAATCTGTTGACCGCGCTAT
AAAAGGCGATAAATACATTGATGAAAAAACTGCCAAAGAAGAAAGCGAAGCAGCTTCTAAAGCCTATGAAGAAAGCATTC
AAAAAGCTCTCAAAGCTGATGCTAGCCAATTTCCACAACTAACCAAAGAAGTCGGCAAAGAAGAAGCTAAGGTCGTAATG
AGGACAAGTCAAGGGGACATCACCCTTAAGTTATTCCCAAAATATGCTCCCTTAGCTGTTGAGAACTTCCTCACCCATGC
TAAAAAAGGCTACTATGATAACCTTACTTTCCATCGTGTGATCAACGACTTTATGATTCAATCAGGTGACCCCAAAGGAG
ATGGCACAGGTGGTGAATCGATTTGGAAGGGCAAGGATCCTAAAAAAGATGCTGGCAATGGCTTTGTCAACGAAATCTCT
CCATTTTTATATCATATTCGCGGTGCTCTTGCCATGGCAAATGCTGGCGCTAATACGAACGGTAGCCAATTTTATATCAA
CCAAAACAAGAAAAATCAAAGCAAGGGATTATCAAGTACCAACTACCCAAAACCTATCATCTCTGCCTATGAGCATGGCG
GCAATCCAAGCTTAGATGGCGGTTATACTGTATTTGGTCAAGTCATTGATGGTATGGATGTTGTCGATAAAATTGCCGCG
ACTTCTATCAACCAAAATGATAAACCAAAACAAGACATTACGATTACCTCAATTGACATTGTCAAAGATTATCGCTTTAA
AAACTAA

Upstream 100 bases:

>100_bases
GTTAGATCATAAAACACAAAAATAGGCGTTTTTAACTCTTTACTACTATTTTCTGTTGTATTTTATGATAAAATAAAGAA
AATCATTCTTAGGAGTAGAC

Downstream 100 bases:

>100_bases
ATCATGCTTAAAAAAACCTTATCAGATAATAGGCTAAATACCTTGGTTTGATAAGGTTTTTTATGGTCTTTTGATGACAT
ATAAAAAACACCCTTTGATG

Product: putative peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEAASKAYEESIQKALKADASQFPQLTKEVGKEEAKVVM
RTSQGDITLKLFPKYAPLAVENFLTHAKKGYYDNLTFHRVINDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEIS
PFLYHIRGALAMANAGANTNGSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAA
TSINQNDKPKQDITITSIDIVKDYRFKN

Sequences:

>Translated_268_residues
MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEAASKAYEESIQKALKADASQFPQLTKEVGKEEAKVVM
RTSQGDITLKLFPKYAPLAVENFLTHAKKGYYDNLTFHRVINDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEIS
PFLYHIRGALAMANAGANTNGSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAA
TSINQNDKPKQDITITSIDIVKDYRFKN
>Mature_268_residues
MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEAASKAYEESIQKALKADASQFPQLTKEVGKEEAKVVM
RTSQGDITLKLFPKYAPLAVENFLTHAKKGYYDNLTFHRVINDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEIS
PFLYHIRGALAMANAGANTNGSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAA
TSINQNDKPKQDITITSIDIVKDYRFKN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=184, Percent_Identity=43.4782608695652, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI19557636, Length=185, Percent_Identity=37.8378378378378, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7706339, Length=183, Percent_Identity=37.7049180327869, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI4758950, Length=175, Percent_Identity=39.4285714285714, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI64276486, Length=187, Percent_Identity=32.0855614973262, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI20911035, Length=179, Percent_Identity=35.7541899441341, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4505991, Length=175, Percent_Identity=39.4285714285714, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI22547215, Length=199, Percent_Identity=36.1809045226131, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI22547212, Length=199, Percent_Identity=36.1809045226131, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7657473, Length=199, Percent_Identity=36.1809045226131, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI42560244, Length=186, Percent_Identity=33.8709677419355, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI150418007, Length=212, Percent_Identity=35.8490566037736, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI6631100, Length=196, Percent_Identity=32.1428571428571, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI5454154, Length=181, Percent_Identity=33.7016574585635, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4826932, Length=191, Percent_Identity=34.0314136125654, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI5031987, Length=176, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5174637, Length=175, Percent_Identity=35.4285714285714, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI10863927, Length=175, Percent_Identity=34.2857142857143, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI45439316, Length=158, Percent_Identity=35.4430379746835, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI303305009, Length=158, Percent_Identity=35.4430379746835, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI14277126, Length=190, Percent_Identity=30.5263157894737, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI310127646, Length=175, Percent_Identity=32.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310114371, Length=175, Percent_Identity=32.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310119221, Length=175, Percent_Identity=32.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI256017253, Length=175, Percent_Identity=33.1428571428571, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI221139811, Length=175, Percent_Identity=33.1428571428571, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI256017251, Length=175, Percent_Identity=33.1428571428571, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786736, Length=192, Percent_Identity=36.4583333333333, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1789763, Length=171, Percent_Identity=36.2573099415205, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=187, Percent_Identity=41.1764705882353, Blast_Score=136, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17539496, Length=190, Percent_Identity=36.8421052631579, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17532641, Length=193, Percent_Identity=36.2694300518135, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17506307, Length=177, Percent_Identity=40.6779661016949, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71980590, Length=173, Percent_Identity=36.4161849710983, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71980594, Length=184, Percent_Identity=35.8695652173913, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71997782, Length=175, Percent_Identity=34.2857142857143, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17552780, Length=178, Percent_Identity=37.0786516853933, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32563659, Length=187, Percent_Identity=31.5508021390374, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565860, Length=215, Percent_Identity=35.3488372093023, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=183, Percent_Identity=36.0655737704918, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=158, Percent_Identity=35.4430379746835, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17566266, Length=182, Percent_Identity=33.5164835164835, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551282, Length=184, Percent_Identity=34.2391304347826, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551284, Length=184, Percent_Identity=34.2391304347826, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559074, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=165, Percent_Identity=34.5454545454545, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=177, Percent_Identity=36.7231638418079, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=159, Percent_Identity=40.251572327044, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320510, Length=209, Percent_Identity=33.9712918660287, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323246, Length=194, Percent_Identity=35.5670103092784, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323562, Length=211, Percent_Identity=34.1232227488152, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322492, Length=208, Percent_Identity=28.8461538461538, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922376, Length=189, Percent_Identity=36.5079365079365, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17986117, Length=186, Percent_Identity=38.1720430107527, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922912, Length=185, Percent_Identity=44.8648648648649, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24652460, Length=185, Percent_Identity=33.5135135135135, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357249, Length=112, Percent_Identity=42.8571428571429, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI20130249, Length=206, Percent_Identity=35.4368932038835, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355677, Length=190, Percent_Identity=34.2105263157895, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586038, Length=187, Percent_Identity=34.7593582887701, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664125, Length=175, Percent_Identity=36, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357783, Length=175, Percent_Identity=36, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45549139, Length=175, Percent_Identity=36.5714285714286, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24650807, Length=185, Percent_Identity=35.6756756756757, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17647301, Length=182, Percent_Identity=34.6153846153846, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29314; Mature: 29314

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEAASKAYEESIQKALKAD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASQFPQLTKEVGKEEAKVVMRTSQGDITLKLFPKYAPLAVENFLTHAKKGYYDNLTFHRV
HHHHHHHHHHHCHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHH
INDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEISPFLYHIRGALAMANAGANTN
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAA
CCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSINQNDKPKQDITITSIDIVKDYRFKN
HCCCCCCCCCCCEEEEEEHHHHHCCCCC
>Mature Secondary Structure
MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEAASKAYEESIQKALKAD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASQFPQLTKEVGKEEAKVVMRTSQGDITLKLFPKYAPLAVENFLTHAKKGYYDNLTFHRV
HHHHHHHHHHHCHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHH
INDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEISPFLYHIRGALAMANAGANTN
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAA
CCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSINQNDKPKQDITITSIDIVKDYRFKN
HCCCCCCCCCCCEEEEEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA