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The map label for this gene is cysM [H]

Identifier: 218931009

GI number: 218931009

Start: 4533415

End: 4534359

Strand: Direct

Name: cysM [H]

Synonym: YPO4018

Alternate gene names: 218931009

Gene position: 4533415-4534359 (Clockwise)

Preceding gene: 218930985

Following gene: 218931010

Centisome position: 97.41

GC content: 37.57

Gene sequence:

>945_bases
ATGGAACTTAAGGATATTGGTAACACCGAGCTTATTGAGCTAAAAAACTTATCAATAAATAATAATTCTCTTTTTTCTAA
GTGCGAATTCAACAATCCTACAGGTAGCCATAAAGACCGAACATTTCTGCATATCCTCAATATCTTGGAAGAAGAAAATA
AAATAATTCCCGGAATGACATTGATAGACTGCTCAACAGGGAATGGAGGTGCAGCACTGGCTTGGATTGGTCAAAAAAAA
GGCTATAAAATTAAAATATTTATGCCTGAAGGCATGACTGAAGAACGCAAAGAACAGATCTATTCATTTGGTGGAGAAAT
TATCGAAACCCCCAAAGAAAACTTCTTAAAGGGTGCTGTAAAAGCAGCAACTGAATACTCAAATCACCAAAAAAACATAT
TCTTTCTCAATCAATCTGACACCACCTTAAATAAAGATGCGTGGCATAGTTGTGGTGAAGAAATTGTCAGAAAAATGAAA
GAGATAAATAAAAAACCTGATTACTTTATTTGTTCAATCGGAACGGGAGGTACATTTTCGGGTATTGCGGAAATTTTGAA
GAAAGCCTACCCACGAATCCATACGGTGGGTATTGAAGTTGATCAATCGGCCCCGATCTATTCACAGCGACATGGTCTTA
ACTTTCATCATAAACATCATAATCTTATGGGGCTAGGTGCTGGTGTTATTTCAGTGAATACCCTTTTAGATTTGATCGAT
GAGGTAAGGGTTGTTAATGGCAAAGCGGCTTGGGAAAGGATGAAAAGCTTCATCGAAAAGGAGCGCTTAGGAATTGGGCC
AACATGTGGAGCTAACTTGTTGATTACGGAAGATATAATGCAAGAAGTTAACGGGAAAGTGATTGTCACTCTATTCTTTG
ATAGTGCATGGAAATATAAAAGTTGCTGGGATGGAGTTTACCCTGGATATAAGGAAACCCAATGA

Upstream 100 bases:

>100_bases
ATAGTATTTAAAATAATTCAAAAAATTAAATTACACATTGATATTTACCCTCCGGGAAATTTATGTTTTATTGTGCACCT
CCATAAAAAAGGAGTGTGTC

Downstream 100 bases:

>100_bases
TTTTATTAAAGAATGTGTATAAAAATGCTCAGGTAGTGAACTCAGGAAAAGCATTAACCACCGTCAATGAATTTACAGAC
CAGTTGCCTGCCCTCAGACC

Product: pyridoxal-phosphate dependent protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGMTLIDCSTGNGGAALAWIGQKK
GYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKMK
EINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKHHNLMGLGAGVISVNTLLDLID
EVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKYKSCWDGVYPGYKETQ

Sequences:

>Translated_314_residues
MELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGMTLIDCSTGNGGAALAWIGQKK
GYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKMK
EINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKHHNLMGLGAGVISVNTLLDLID
EVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKYKSCWDGVYPGYKETQ
>Mature_314_residues
MELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGMTLIDCSTGNGGAALAWIGQKK
GYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKMK
EINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKHHNLMGLGAGVISVNTLLDLID
EVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKYKSCWDGVYPGYKETQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=27.4760383386581, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=29.5081967213115, Blast_Score=101, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=32.2259136212625, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=28.7625418060201, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=28.7625418060201, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=28.2392026578073, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=29.2358803986711, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25147552, Length=207, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534315, Length=118, Percent_Identity=35.5932203389831, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=24.6511627906977, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539800, Length=240, Percent_Identity=26.25, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=309, Percent_Identity=29.4498381877023, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=25.8358662613982, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24643623, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129101, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35295; Mature: 35295

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGMT
CCCCCCCCCEEEEEEECEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
LIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAV
EEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHCCCCHHHHHHHHH
KAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKMKEINKKPDYFICSIGTGGTFS
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
GIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKHHNLMGLGAGVISVNTLLDLID
HHHHHHHHHCCCEEEEEEEECCCCCCHHHHCCCCEECCCCCEEECCCHHHHHHHHHHHHH
EVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKYK
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHCCCCEEEEEEECCCCCHH
SCWDGVYPGYKETQ
HHHCCCCCCCCCCC
>Mature Secondary Structure
MELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGMT
CCCCCCCCCEEEEEEECEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
LIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAV
EEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHCCCCHHHHHHHHH
KAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKMKEINKKPDYFICSIGTGGTFS
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
GIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKHHNLMGLGAGVISVNTLLDLID
HHHHHHHHHCCCEEEEEEEECCCCCCHHHHCCCCEECCCCCEEECCCHHHHHHHHHHHHH
EVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKYK
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHCCCCEEEEEEECCCCCHH
SCWDGVYPGYKETQ
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA