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The map label for this gene is gor [H]

Identifier: 218930972

GI number: 218930972

Start: 4478018

End: 4479370

Strand: Direct

Name: gor [H]

Synonym: YPO3977

Alternate gene names: 218930972

Gene position: 4478018-4479370 (Clockwise)

Preceding gene: 218930971

Following gene: 218930973

Centisome position: 96.22

GC content: 51.81

Gene sequence:

>1353_bases
ATGACCAAACATTACGATTATCTGGCAATTGGCGGTGGCAGTGGCGGGATCGCATCGATCAACCGGGCAGCCATGTACGG
TAAAAAATGCGCATTGATCGAAGCTAAACAGCTCGGTGGCACCTGTGTTAACGTCGGTTGTGTGCCAAAGAAAGTGATGT
GGCATGCAGCGCAGATTGCGGAAGCCATTCATTTGTACGGCCCGGATTACGGCTTCGACACCACAGTGAACCACTTCGAT
TGGAAAAAGCTGATTGCTAACCGTACTGCTTACATCGATCGTATCCATCAGTCCTATGAGCGCGGTTTAGGCAATAATAA
AGTGGATGTTATCCAAGGCTTCGCCCGCTTTGTGGATGCCCACACCGTGGAAGTTAACGGTGAGACGATCACCGCAGATC
ACATTCTGATCGCTACCGGTGGCCGCCCAAGCCATCCCGATATCCCTGGTGCTGAATACGGTATCGACTCCGATGGTTTC
TTCGAATTAGATGAGATGCCAAAACGTGTCGCTGTCGTGGGCGCAGGTTATATCGCGGTAGAAATTGCTGGCGTACTCAA
CGGGTTAGGTACCGAGACACACTTGTTTGTCCGCAAACATGCACCGTTGCGTACCTTTGATCCGCTAATTGTTGAAACCC
TGTTGGAAGTGATGAACACCGAAGGGCCGAAACTGCATACCGAATCGGTACCGAAAGCGGTTATCAAAAACGCCGATGGC
AGCCTGACGCTGCAATTAGAAAATGGTACTGAAGTCACTGTTGACCACCTGATCTGGGCGATTGGCCGTGAACCCGCAAC
CGACAACCTGAACCTGTCTGTCACCGGTGTTAAGACCAATGACAAAGGCTATATCGAGGTTGATAAGTTCCAGAACACCA
ACGTCAAAGGCATCTACGCCGTCGGTGATAACACTGGCGTAGTTGAACTGACCCCGGTTGCCGTTGCGGCGGGCCGCCGT
TTGTCCGAACGTCTGTTCAATAACAAGCCGGATGAGCATTTGGATTACAGCAATATCCCAACCGTGGTATTCAGCCATCC
GCCAATCGGTACTATCGGCCTGACCGAGCCACAAGCCAGAGAGAAATTTGGCGACGATCAGGTGAAAGTGTACACATCCT
CGTTCACCGCGATGTACAGTGCTGTCACTCAACACCGCCAGCCATGCCGGATGAAATTAGTCTGCGTGGGTGCCGAAGAG
AAGATTGTCGGTATTCACGGCATCGGTTTCGGAATGGACGAGATCCTGCAAGGGTTCGCAGTCGCCATGAAGATGGGCGC
GACCAAGAAAGATTTCGACAACACTGTCGCTATCCACCCTACCGCCGCAGAAGAGTTCGTTACCATGAGATGA

Upstream 100 bases:

>100_bases
ACACTGTTAGGCAATTTTAAACGACTCTACCCTCAATAATGCGCGTTACGCGAAAGCGGCAACGTGCAGTATGACCGGGT
ATCTCATGGAAACGACCCTG

Downstream 100 bases:

>100_bases
TTTCGTTACTATGGCCCGAACAGGCAGAGACTCCTGCACGGGCCATGTTTCTGAAATACACTAAGCCAGGTTGAAAATGA
GCTAACCTGGCTTTTATCTT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD
WKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADG
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVELTPVAVAAGRR
LSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEE
KIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR

Sequences:

>Translated_450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD
WKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADG
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVELTPVAVAAGRR
LSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEE
KIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR
>Mature_449_residues
TKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFDW
KKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFF
ELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADGS
LTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVELTPVAVAAGRRL
SERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEK
IVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=53.8961038961039, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.5789473684211, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=37.0614035087719, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=37.0614035087719, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=37.0614035087719, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=37.0614035087719, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=34.1356673960613, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=31.5098468271335, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=27.7292576419214, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=85.3333333333333, Blast_Score=791, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=29.2035398230088, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=30.0215982721382, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=26.5350877192982, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56.6666666666667, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=56.6666666666667, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=35.5789473684211, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.0956340956341, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=27.9220779220779, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17559934, Length=186, Percent_Identity=30.1075268817204, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=50.752688172043, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=26.9067796610169, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.3070362473348, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=40.0852878464819, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=40.1273885350318, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=40.1273885350318, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=38.2663847780127, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.4372294372294, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48920; Mature: 48789

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEEECCHHEE
EIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADG
EHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCC
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEE
VGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAR
ECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
EKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
VAMKMGATKKDFDNTVAIHPTAAEEFVTMR
HHHHCCCCCCCCCCEEEECCCCHHHHEECC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEEECCHHEE
EIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADG
EHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCC
SLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEE
VGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAR
ECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
EKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFA
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
VAMKMGATKKDFDNTVAIHPTAAEEFVTMR
HHHHCCCCCCCCCCEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]