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The map label for this gene is opdA [H]

Identifier: 218930970

GI number: 218930970

Start: 4474619

End: 4476661

Strand: Reverse

Name: opdA [H]

Synonym: YPO3975

Alternate gene names: 218930970

Gene position: 4476661-4474619 (Counterclockwise)

Preceding gene: 218930976

Following gene: 218930969

Centisome position: 96.2

GC content: 51.98

Gene sequence:

>2043_bases
ATGACAAACCCGCTGTTGACTCCGTTCTCCCTGCCACCGTTTTCTGCTATTCGGCCTGAAGATATCGTGCCTGCGGTGAA
ATCCGCGCTGGATGAATGCCGTCAAGCGGTAGAGCGTGTGGTTGCCCAATCAGGGCCGTTCACCTGGGATAATCTGTGTC
AGCCACTGGCCGAATCCGATGACCGCTTATCGCGCATTTGGTCACCCGTAGGCCACTTGAACTCAGTAAAAAATAGCCCT
GAGCTGCGTACCGCTTATGAACAAAGCTTGCCATTGCTGTCGGAATACGGCACTTGGGTGGGGCAGCATAAAGGTTTGTA
TCAGGCGTATGTCAGCCTGAAAGAGGGGCCGGGTTTTGCCGCCTTGACCGCACCGCAGCGCAAAGCGGTAGAAAATGCTC
TGCGTGACTTCCAGCTATCCGGTATTGGTCTGGCGCCTGAACAACAAAAGCGTTACGGCGAAATCGTGGCTCGCTTGTCG
GAGCTTGGCTCGACTTACAGCAATAACGTGCTTGATGCCACCATGGGGTGGAGCAAACTGATTACCGATGTTGAGCAACT
GAAAGGTTTGCCAGAAAGCGCGCTCGCAGCGGCCAAAGCCATGGCAGAAGCCAAAGAGCAGGACGGCTGGTTGCTGACAC
TGGATATGCCAAGCTATCTGCCGGTACTGACTTATGCCGATAACGTGGAATTGCGCGAAGAGATGTACCGTGCATTTGCC
ACCCGTGCTTCTGATCAGGGGCCAAACGCGGGGAAATGGGATAACAGCGAGATCATGGCGGAAATTCTGACACTGCGTCA
TGAATTAGCGCAGTTGCTCGGTTTTAACAGTTATGCCGATAAATCGCTGGCCACCAAAATGGCAGAAAACCCACAGCAGG
TATTGGGCTTCCTGAACGATCTGGCGAAGCGCGCCCGCCCGCAAGCAGAAGAAGAGCTGGCTCAGTTACGTGCTTTTGCT
AAAGAGCATTATGGTGTCAGTGAACTCCAGGCTTGGGATATCACCTATTATTCCGAGAAACAGAAACAGCATCTGTTTGC
TATCAGTGATGAACAACTTCGTCCTTATTTCCCGGAACAGCGGGTGGTGGAAGGTTTATTCGAAGTGGTGAAACGCATTT
ATGGCATTACAGCCAAAGAGCGCCATGATGTCGATACCTGGCATCCGGATGTCCGCTTCTTCGATTTGTTTGATGCCGAT
GGTGAACTGCGCGGTAGCTTCTACCTTGATTTGTATGCGCGCGAAAACAAGCGTGGCGGAGCCTGGATGGATGACTGCGT
AGGTAGCCTGCGTTTGGCTAATGGCCAACTGCAAAAACCAGTCGCTTATCTGACTTGCAATTTTAACGGGCCCGTTGGCG
GCAAACCGGCGCTGTTTACTCACAATGAAGTGACCACCTTGTTCCATGAGTTCGGCCATGGTTTACATCATATGCTGACC
AAAATTGATACCGCAGGCGTTTCTGGTATCAATGGCGTGCCTTGGGATGCAGTCGAGCTGCCAAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCCTTTATTTCTGGTCATTACCAAACTCATGAGCCTTTGCCGCAAGAGATGCTGG
ATAAACTACTGGCGGCGAAAAACTATCAGGCGGCGTTGTTTATTCTGCGCCAACTGGAGTTTGGTCTGTTCGATTTCCGG
ATGCATTATGAGTTCGACCCGCTGACCGGTGCGCAGATCCTGCCTATTTTGTATGAAGTGAAAAAACAGGTTGCTGTGGT
GCCATCACCGGAATGGGGCCGCTTCCCTCATGCCTTCAGCCATATTTTTGCTGGCGGTTATGCGGCCGGTTATTACAGCT
ATTTATGGGCTGAAGTGCTCTCGGCGGATGCGTTCTCACGCTTTGAAGAAGAAGGGATTTTTAATGCCGCTACCGGTCAG
TCCTTCCTCGACAACATTCTGTCTCAAGGTGGCTCAGAGGAGCCAATGACACTGTTCAAACGCTTCCGTGGCCGTGAACC
GCAGTTAGATGCCATGTTGCGTCATTACGGTATTAAGGGCTAA

Upstream 100 bases:

>100_bases
ATGTTAATTGTTCATTCGTAATTTATTCTCCGTCGCTGGATGCGTCTGGCGTTTGGTATATAAACGTTATTAAAATTCAA
ATCATAACCAGGACTGCCCT

Downstream 100 bases:

>100_bases
TACGTGTCACACGTCAGTATTTGTTTATTATCTGAAGCAGGCGCCGATCCCGGCGCCTTATCTATTCTGGCTGATCGCTG
GGGGTTAGTCTCTGACGATC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQSGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNVELREEMYRAFA
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFA
KEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDAD
GELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQ
SFLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQSGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNVELREEMYRAFA
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFA
KEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDAD
GELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQ
SFLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG
>Mature_679_residues
TNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQSGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSPE
LRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSE
LGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNVELREEMYRAFAT
RASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFAK
EHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADG
ELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLTK
IDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFRM
HYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQS
FLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=617, Percent_Identity=34.0356564019449, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI14149738, Length=676, Percent_Identity=30.1775147928994, Blast_Score=286, Evalue=6e-77,
Organism=Homo sapiens, GI156105687, Length=679, Percent_Identity=26.5095729013255, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=80.7352941176471, Blast_Score=1135, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=685, Percent_Identity=30.6569343065693, Blast_Score=298, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI71999758, Length=589, Percent_Identity=25.6366723259762, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=618, Percent_Identity=22.9773462783171, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319793, Length=692, Percent_Identity=28.757225433526, Blast_Score=298, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6322715, Length=699, Percent_Identity=23.4620886981402, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356111, Length=551, Percent_Identity=29.4010889292196, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI20129717, Length=685, Percent_Identity=25.1094890510949, Blast_Score=182, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76532; Mature: 76401

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQSGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEE
ALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSELGSTYSNNVLDATMGWSKL
EECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNVELREEMYRAFA
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLND
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEEELAQLRAFAKEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCHHHHHEEEECCCCCCCCCCHH
RVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCC
AWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NYQAALFILRQLEFGLFDFRMHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQSFLDNILSQGGSEEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQSGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEE
ALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSELGSTYSNNVLDATMGWSKL
EECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNVELREEMYRAFA
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLND
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEEELAQLRAFAKEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCHHHHHEEEECCCCCCCCCCHH
RVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCC
AWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NYQAALFILRQLEFGLFDFRMHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQSFLDNILSQGGSEEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]