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The map label for this gene is asd [H]

Identifier: 218930945

GI number: 218930945

Start: 4447118

End: 4448221

Strand: Reverse

Name: asd [H]

Synonym: YPO3949

Alternate gene names: 218930945

Gene position: 4448221-4447118 (Counterclockwise)

Preceding gene: 218930947

Following gene: 218930944

Centisome position: 95.58

GC content: 50.82

Gene sequence:

>1104_bases
ATGAAAAACGTTGGTTTTATCGGCTGGCGCGGTATGGTCGGCTCAGTGCTCATGCAACGCATGATTGAAGAACGCGACTT
TGACGGTATCCGCCCAGTCTTTTTCTCTACCTCTCAACATGGCCAGGCTGCACCGGCTTTCGCGGGCCACCAAGGTACGT
TGCAAGATGCTTATGATATTGATGCATTGAGTGCATTGGATATCATCATCACCTGCCAAGGGGGCGACTATACCAACCAA
ATTTATCCGAAGCTGCGTGAAATCGGTTGGCAAGGCTATTGGATTGACGCCGCTTCTTCGCTGCGTATGCAAGATGACAC
CATTATTATTCTGGATCCGGTTAACCACGATGTGATTAAGCAGGGGCTGGATAAGGGGATCAAAACCTTTGCAGGCGGTA
ACTGTACCGTTAGCCTGATGCTAATGTCATTGGGCGGTTTGTTTGCCAATAATCTGGTGGAGTGGGCATCGGTTGCCACT
TATCAGGCCGCATCTGGCGGCGGCGCTCGTCATATGCGTGAATTACTGACCCAAATGGGTATGCTACATGCTGGTGTGGC
AAAAGAGTTGCAAGACCCGGCATCTGCCATTTTGGATATTGAACGCAAAGTGACGTCAACAACTCGCAGTGGCACGTTAC
CGACCGATAATTTTGGTGTGCCGCTAGCAGGTAGCCTCATCCCGTGGATCGACAAAGCGTTGGATAATGGTCAGAGCCGT
GAAGAGTGGAAAGGCCAGGCCGAGACCAATAAAATTCTGAGTACCAGTACTCTGATTCCTGTTGATGGCCTATGTGTGCG
TGTTGGTGCGCTGCGTTGTCATAGCCAAGCCTTTACTCTGAAACTGAAAAAAGACGTTCCATTAGCCGAAATCGAGCAAA
TGCTGGCGACGCACAATGACTGGGTACGGGTTATTCCGAATGATCGTGAATTGAGTATGCGTGAACTGACACCTGCTGCG
GTCACCGGCACATTGAATACCCCAGTTGGCCGCTTGCGCAAGCTGAATATGGGGCCAGAATATTTGTCCGCCTTTACCGT
TGGTGATCAACTGTTATGGGGGGCTGCTGAGCCACTGCGCCGTATGCTGCGAATTCTGCTGTAG

Upstream 100 bases:

>100_bases
CAACCTTGCCGCAACCCCCACTTACATTGGGTAACCGCGCGCAGTTATACAAGACAGGTATCCATAAATCGGTGTCACCT
TCCAAGGCAGGGCAGTAAAC

Downstream 100 bases:

>100_bases
ACTATTTTTTAGCGTCGCATAGTGTCGTGGAAGACCCGTAAGCCCGCCAGAGTGCGGGCTTTGTTTATCGTATGCTGTCG
CACATACTTCTACCTAATAA

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKNVGFIGWRGMVGSVLMQRMIEERDFDGIRPVFFSTSQHGQAAPAFAGHQGTLQDAYDIDALSALDIIITCQGGDYTNQ
IYPKLREIGWQGYWIDAASSLRMQDDTIIILDPVNHDVIKQGLDKGIKTFAGGNCTVSLMLMSLGGLFANNLVEWASVAT
YQAASGGGARHMRELLTQMGMLHAGVAKELQDPASAILDIERKVTSTTRSGTLPTDNFGVPLAGSLIPWIDKALDNGQSR
EEWKGQAETNKILSTSTLIPVDGLCVRVGALRCHSQAFTLKLKKDVPLAEIEQMLATHNDWVRVIPNDRELSMRELTPAA
VTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRILL

Sequences:

>Translated_367_residues
MKNVGFIGWRGMVGSVLMQRMIEERDFDGIRPVFFSTSQHGQAAPAFAGHQGTLQDAYDIDALSALDIIITCQGGDYTNQ
IYPKLREIGWQGYWIDAASSLRMQDDTIIILDPVNHDVIKQGLDKGIKTFAGGNCTVSLMLMSLGGLFANNLVEWASVAT
YQAASGGGARHMRELLTQMGMLHAGVAKELQDPASAILDIERKVTSTTRSGTLPTDNFGVPLAGSLIPWIDKALDNGQSR
EEWKGQAETNKILSTSTLIPVDGLCVRVGALRCHSQAFTLKLKKDVPLAEIEQMLATHNDWVRVIPNDRELSMRELTPAA
VTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRILL
>Mature_367_residues
MKNVGFIGWRGMVGSVLMQRMIEERDFDGIRPVFFSTSQHGQAAPAFAGHQGTLQDAYDIDALSALDIIITCQGGDYTNQ
IYPKLREIGWQGYWIDAASSLRMQDDTIIILDPVNHDVIKQGLDKGIKTFAGGNCTVSLMLMSLGGLFANNLVEWASVAT
YQAASGGGARHMRELLTQMGMLHAGVAKELQDPASAILDIERKVTSTTRSGTLPTDNFGVPLAGSLIPWIDKALDNGQSR
EEWKGQAETNKILSTSTLIPVDGLCVRVGALRCHSQAFTLKLKKDVPLAEIEQMLATHNDWVRVIPNDRELSMRELTPAA
VTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRILL

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=366, Percent_Identity=83.6065573770492, Blast_Score=646, Evalue=0.0,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40192; Mature: 40192

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVGFIGWRGMVGSVLMQRMIEERDFDGIRPVFFSTSQHGQAAPAFAGHQGTLQDAYDI
CCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHCC
DALSALDIIITCQGGDYTNQIYPKLREIGWQGYWIDAASSLRMQDDTIIILDPVNHDVIK
HHHCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCHHHHH
QGLDKGIKTFAGGNCTVSLMLMSLGGLFANNLVEWASVATYQAASGGGARHMRELLTQMG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLHAGVAKELQDPASAILDIERKVTSTTRSGTLPTDNFGVPLAGSLIPWIDKALDNGQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
EEWKGQAETNKILSTSTLIPVDGLCVRVGALRCHSQAFTLKLKKDVPLAEIEQMLATHND
HHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCC
WVRVIPNDRELSMRELTPAAVTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLR
EEEECCCCCCCHHHHCCCHHEECCCCCCHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHH
RMLRILL
HHHHHHC
>Mature Secondary Structure
MKNVGFIGWRGMVGSVLMQRMIEERDFDGIRPVFFSTSQHGQAAPAFAGHQGTLQDAYDI
CCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHCC
DALSALDIIITCQGGDYTNQIYPKLREIGWQGYWIDAASSLRMQDDTIIILDPVNHDVIK
HHHCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCHHHHH
QGLDKGIKTFAGGNCTVSLMLMSLGGLFANNLVEWASVATYQAASGGGARHMRELLTQMG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLHAGVAKELQDPASAILDIERKVTSTTRSGTLPTDNFGVPLAGSLIPWIDKALDNGQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
EEWKGQAETNKILSTSTLIPVDGLCVRVGALRCHSQAFTLKLKKDVPLAEIEQMLATHND
HHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCC
WVRVIPNDRELSMRELTPAAVTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLR
EEEECCCCCCCHHHHCCCHHEECCCCCCHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHH
RMLRILL
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]