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The map label for this gene is argH [H]

Identifier: 218930923

GI number: 218930923

Start: 4408919

End: 4410292

Strand: Reverse

Name: argH [H]

Synonym: YPO3924

Alternate gene names: 218930923

Gene position: 4410292-4408919 (Counterclockwise)

Preceding gene: 218930924

Following gene: 218930922

Centisome position: 94.77

GC content: 50.66

Gene sequence:

>1374_bases
ATGGCACTATGGGGCGGACGGTTTAGTCAGGCAGCAGATCAGCGTTTTAAGCAATTCAATGATTCACTGCGGTTTGATTA
CCGGCTGGCAGAGCAGGATATTATCGGTTCTGTTGCCTGGTCGAAAGCGCTGGTTACTGTTGGCGTATTGAACGCTGATG
AACAGCAACAACTTGAACAGGCGCTGTCAGTTTTACTGGAAGAGGTGCAGGCCAACCCACACGCTATTTTGGCCAGTGAC
GCTGAAGATATCCACAGTTGGGTCGAAACCAAACTGATCGATAAAGTGGGTGATTTAGGCAAAAAATTACACACTGGGCG
CAGCCGTAATGATCAGGTAGCGACCGATCTGAAATTGTGGTGTAAGTTCCAGATAACCGAATTACAGACGGCGGTACAAC
AACTGCAACAGGCGTTGGTCATGACCGCTGAAGCGAATCAGGATGCGGTCATGCCTGGTTATACTCACTTACAGCGTGCT
CAACCCGTGACGTTTGCACATTGGTGTTTGGCCTATGTAGAAATGCTGTCACGTGATGAAAGCCGTTTACAAGATACCCT
GAAACGTCTGGATGTTAGCCCATTAGGTTGCGGTGCGTTGGCGGGCACGGCGTATGCTATCGATCGTGAACAACTGGCGG
GCTGGTTGGGCTTTGCTTCTGCTACTCGTAACAGCCTGGACAGCGTTTCTGACCGTGACCATGTGCTGGAGCTATTATCT
GACGCCAGCATTGGTATGGTACATTTGTCTCGCTTTGCTGAAGATTTAATTTTCTTCAACAGCGGTGAAGCAGCTTTTGT
CGATTTATCGGATCGCGTGACATCGGGTTCCTCCCTAATGCCACAGAAGAAAAATCCAGATGCGCTGGAGCTCATCCGTG
GTAAATGTGGCCGGGTGCAAGGTGCATTAACTGGGATGACGATGACGCTCAAAGGCCTGCCTTTGGCTTATAACAAAGAT
ATGCAGGAAGACAAAGAAGGGCTGTTTGATGCACTGGATACCTGGCTTGACTGCCTGCACATGGCGGCATTGGTACTGGA
TGGGATTCAGGTAAAACGCCCGCGTTGTAAAGAAGCGGCTGAACAGGGCTATGCTAACGCGACTGAACTGGCTGATTATT
TGGTCGCTAAAGGCGTACCGTTCCGTGAAGCGCACCATATTGTGGGTGAAGCGGTGGTAGAGGCAATCCGCCAGGGCAAA
GCTCTGGAGGCCTTAGCGCTGAGTGATTTACAGCAATTCAGTTCCGTAATTGGTGATGATGTGTACCCGATTCTGGCATT
GCAGTCTTGCTTAGATAAGCGAGTGGCCAAAGGCGGCGTTTCGCCGCAGCAGGTTGCATCGGCCATTGCCGAGGCTAAAG
CGCGGCTGTTTTAA

Upstream 100 bases:

>100_bases
CTCATCCGTAAGTAAGTGATTCGGGTGAGTGGGCGCAGCTAACAACCCTGTAGCTTCGAGGACGAAGGGTTTTCTATTAA
GAATTTAGGGAAGCAAGATT

Downstream 100 bases:

>100_bases
TTTGCTGGGTTTTAATCTTGAGAACGGGGCGGGCCGCTAATTGCAGCGGCCCGCTTTGCATTAACAGTTACTACCCTTAA
CAGAGCTATTATCCTTAACA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQALSVLLEEVQANPHAILASD
AEDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLWCKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRA
QPVTFAHWCLAYVEMLSRDESRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
DASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMTMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCKEAAEQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGK
ALEALALSDLQQFSSVIGDDVYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF

Sequences:

>Translated_457_residues
MALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQALSVLLEEVQANPHAILASD
AEDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLWCKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRA
QPVTFAHWCLAYVEMLSRDESRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
DASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMTMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCKEAAEQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGK
ALEALALSDLQQFSSVIGDDVYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF
>Mature_456_residues
ALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQALSVLLEEVQANPHAILASDA
EDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLWCKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRAQ
PVTFAHWCLAYVEMLSRDESRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSD
ASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMTMTLKGLPLAYNKDM
QEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCKEAAEQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKA
LEALALSDLQQFSSVIGDDVYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=45.374449339207, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=45.374449339207, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=42.9515418502203, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=42.511013215859, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=89.0350877192982, Blast_Score=832, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=44.6389496717724, Blast_Score=375, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=43.3408577878104, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=43.3408577878104, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50101; Mature: 49969

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALWGGRFSQAADQRFKQFNDSLRFDYRLAEQDIIGSVAWSKALVTVGVLNADEQQQLEQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALSVLLEEVQANPHAILASDAEDIHSWVETKLIDKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKFQITELQTAVQQLQQALVMTAEANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLSRDE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCH
SRLQDTLKRLDVSPLGCGALAGTAYAIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DASIGMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQ
CCCHHHHHHHHHHHHHHEECCCCEEEEECHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALTGMTMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCKEAA
HHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHH
EQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEALALSDLQQFSSVIGDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
VYPILALQSCLDKRVAKGGVSPQQVASAIAEAKARLF
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA