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The map label for this gene is fabR [H]

Identifier: 218930913

GI number: 218930913

Start: 4395038

End: 4395685

Strand: Reverse

Name: fabR [H]

Synonym: YPO3913

Alternate gene names: 218930913

Gene position: 4395685-4395038 (Counterclockwise)

Preceding gene: 218930915

Following gene: 218930912

Centisome position: 94.46

GC content: 51.39

Gene sequence:

>648_bases
TTGGGTACGATTATGGGCGTCAGAGCACAACAAAAAGAGCGGACTCGTCGTTCCCTTATCGAAGCGGCGTTCAGTCAACT
GAGTGCTGAGCGGAGCTTTGCCAGCCTGAGCTTACGGGAAGTCTCCCGTGAAGCAGGTATCGCACCGACTTCTTTTTACC
GGCATTTCCGGGATGTCGACGAGCTTGGGCTAACCATGGTTGACGAAAGCGGCCTGATGTTACGTCAATTAATGCGTCAG
GCACGGCAACGGATTGCCAAAGGCGGCAGCGTTATCCGTACATCGGTGTCCACCTTTATGGAGTTTATCGGCAACAACCC
TAATGCGTTTCGTTTGCTGCTCAGGGAACGTTCCGGGACTTCCGCCGCTTTTCGTGCTGCGGTTGCGCGTGAAATTCAGC
ACTTTATTGCTGAACTGGCAGATTACCTCGAGTTAGAAAATCACATGCCACGTAGCTTCACTGAGGCTCAAGCTGAGGCC
ATGGTCACAATTGTCTTCAGTGCAGGTGCAGAAGTACTGGACGTGGATATTGAACAGCGGCGACAGTTAGAAGAACGCTT
GGTCTTACAGTTACGGATGATCTCCAAAGGTGCTTACTATTGGTATCGCCGTGAACAAGAAAAGCTTGCTGCGTCCCGTG
TAGAATAA

Upstream 100 bases:

>100_bases
CGCAATTCGGTATTGAGAAGATACGTTTGTATAACGGTTGTTACCGCAAAGTTTGGTATATTGCTGACTATATGTCTTAG
ATTGAGAAATTGGATATCCC

Downstream 100 bases:

>100_bases
GGTAAAGAAAATATGGAACAATCTTCTCGCCGTGAAACCGGCACCCTACTACTGGCATTAATTACTGGCTTGGCGATAAA
TGGGGTATGTGCCGCGTTAT

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MGTIMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQ
ARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEA
MVTIVFSAGAEVLDVDIEQRRQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE

Sequences:

>Translated_215_residues
MGTIMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQ
ARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEA
MVTIVFSAGAEVLDVDIEQRRQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE
>Mature_214_residues
GTIMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQA
RQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAM
VTIVFSAGAEVLDVDIEQRRQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=206, Percent_Identity=96.1165048543689, Blast_Score=401, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24570; Mature: 24438

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTIMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGT
HHCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
SAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMVTIVFSAGAEVLDVDIEQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHEECCHHHH
RQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GTIMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGT
HHCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
SAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMVTIVFSAGAEVLDVDIEQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHEECCHHHH
RQLEERLVLQLRMISKGAYYWYRREQEKLAASRVE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA