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The map label for this gene is livM [H]

Identifier: 218930808

GI number: 218930808

Start: 4271854

End: 4273140

Strand: Reverse

Name: livM [H]

Synonym: YPO3806

Alternate gene names: 218930808

Gene position: 4273140-4271854 (Counterclockwise)

Preceding gene: 218930809

Following gene: 218930807

Centisome position: 91.82

GC content: 52.53

Gene sequence:

>1287_bases
ATGAAACAGCTCAACTTCGTTAATGCCATTATTTCCAGCTTTGTGTTACTGGTCCTCGCCTCGTTTGTGATGGGGTTGCA
GTTGCAGTTAGACGGCACCCGATTGGTGGTACAAGGTGCTTCGGAAGTCCGTTGGTTGTGGATTGGTGCCGGTTGTCTGG
TGGTTTTTTGCTTCCAACTGGTACGCCCGCTCATACAACAAGGGATTAAAAAAGTCTCAGGCCCGGCGTGGGTGCTGCCC
AGTTTTGATGGCACCACACCGCGGCAAAAACTCTTGGCAGCCGTGGTTATTATCGCCGCAGTTGCCTGGCCATTTTTAGT
CTCTCGCGGCTCTGTCGATATCGCCACCCTAACGCTGATTTACGTCATGTTGGGGCTGGGATTGAATGTCGTCGTCGGGC
TATCAGGCCTGCTGGTACTGGGTTACGGCGGTTTTTATGCCATTGGTGCCTATACTTACGCGCTGCTAAATCACTATTAC
GGTTTAGGATTTTGGGAAAGCCTACCGCTGGCCGGGATAACCGCCGCGCTATCAGGCTTCCTGCTAGGCTTCCCGGTACT
GCGTTTACGTGGGGATTATCTGGCCATTGTGACACTGGGCTTTGGTGAGATTGTGCGTATTTTACTGCTCAATAACACTG
AGATCACCGGGGGGCCGAATGGCATCAGCCAAATCCCTAAACCAACGCTGTTTGGTTTGGAATTTAGCCGCACGGCGAAA
GATGGCGGTTGGGATACCTTCCATAACTTCTTTGGCCTGACTTACGATCCCAGCCACCGCATCATTTTCCTGTATCTGGT
GGCGTTATTATTGGTGATCCTGACGCTGTTCGTCATTAACCGGTTACTGCGTATGCCGCTGGGCCGTGCGTGGGAAGCAC
TGCGTGAAGATGAAATCGCCTGCCGCTCACTGGGTCTCAGCCCGACCAAAATTAAGCTGACGGCATTTACCATCAGCGCG
GCCTTTGCAGGTTTTGCCGGTACCTTGTTTGCTGCCCGGCAGGGGTTTGTCAGCCCAGAGTCTTTCACCTTTGTTGAATC
GGCTTTCGTTCTGGCGATAGTGGTGCTAGGCGGGATGGGTTCGCAGTTTGCAGTCATTTTGGCTGCCGTGTTGCTCGTTG
TTTCGCGCGAATTAATGCGAGATCTCAACGCTTACAGCATGTTGCTATTGGGGGCGTTAATGGTCTTGATGATGATCTGG
CGGCCGCAAGGGTTATTGCCGATGAAACGGCCACAACTGAAGCTGAAAGTTGCTGATGTAAAGGCTAAGCAGGGAGAGCA
GGCATGA

Upstream 100 bases:

>100_bases
TCAGCACTGAATACAAAGATGCGGTTTCATTCGCGCTGCTGATTGTGGTGTTGTTAGTGATGCCTACCGGGATTTTAGGC
CGTCCGGAGGTTGAAAAAGT

Downstream 100 bases:

>100_bases
ATGGGCAACCTTTGTTAACAGTCGAAGGGCTGTCGATGCGTTTTGGTGGATTACTGGCGGTCAATAACGTTGGCTTGACG
TTGAATCAGGGGGAGATTGT

Product: leucine/isoleucine/valine transporter permease subunit

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKQLNFVNAIISSFVLLVLASFVMGLQLQLDGTRLVVQGASEVRWLWIGAGCLVVFCFQLVRPLIQQGIKKVSGPAWVLP
SFDGTTPRQKLLAAVVIIAAVAWPFLVSRGSVDIATLTLIYVMLGLGLNVVVGLSGLLVLGYGGFYAIGAYTYALLNHYY
GLGFWESLPLAGITAALSGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAK
DGGWDTFHNFFGLTYDPSHRIIFLYLVALLLVILTLFVINRLLRMPLGRAWEALREDEIACRSLGLSPTKIKLTAFTISA
AFAGFAGTLFAARQGFVSPESFTFVESAFVLAIVVLGGMGSQFAVILAAVLLVVSRELMRDLNAYSMLLLGALMVLMMIW
RPQGLLPMKRPQLKLKVADVKAKQGEQA

Sequences:

>Translated_428_residues
MKQLNFVNAIISSFVLLVLASFVMGLQLQLDGTRLVVQGASEVRWLWIGAGCLVVFCFQLVRPLIQQGIKKVSGPAWVLP
SFDGTTPRQKLLAAVVIIAAVAWPFLVSRGSVDIATLTLIYVMLGLGLNVVVGLSGLLVLGYGGFYAIGAYTYALLNHYY
GLGFWESLPLAGITAALSGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAK
DGGWDTFHNFFGLTYDPSHRIIFLYLVALLLVILTLFVINRLLRMPLGRAWEALREDEIACRSLGLSPTKIKLTAFTISA
AFAGFAGTLFAARQGFVSPESFTFVESAFVLAIVVLGGMGSQFAVILAAVLLVVSRELMRDLNAYSMLLLGALMVLMMIW
RPQGLLPMKRPQLKLKVADVKAKQGEQA
>Mature_428_residues
MKQLNFVNAIISSFVLLVLASFVMGLQLQLDGTRLVVQGASEVRWLWIGAGCLVVFCFQLVRPLIQQGIKKVSGPAWVLP
SFDGTTPRQKLLAAVVIIAAVAWPFLVSRGSVDIATLTLIYVMLGLGLNVVVGLSGLLVLGYGGFYAIGAYTYALLNHYY
GLGFWESLPLAGITAALSGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAK
DGGWDTFHNFFGLTYDPSHRIIFLYLVALLLVILTLFVINRLLRMPLGRAWEALREDEIACRSLGLSPTKIKLTAFTISA
AFAGFAGTLFAARQGFVSPESFTFVESAFVLAIVVLGGMGSQFAVILAAVLLVVSRELMRDLNAYSMLLLGALMVLMMIW
RPQGLLPMKRPQLKLKVADVKAKQGEQA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=428, Percent_Identity=79.4392523364486, Blast_Score=647, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46508; Mature: 46508

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLNFVNAIISSFVLLVLASFVMGLQLQLDGTRLVVQGASEVRWLWIGAGCLVVFCFQL
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHH
VRPLIQQGIKKVSGPAWVLPSFDGTTPRQKLLAAVVIIAAVAWPFLVSRGSVDIATLTLI
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
YVMLGLGLNVVVGLSGLLVLGYGGFYAIGAYTYALLNHYYGLGFWESLPLAGITAALSGF
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
LLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAK
HHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEECCCCCCCCC
DGGWDTFHNFFGLTYDPSHRIIFLYLVALLLVILTLFVINRLLRMPLGRAWEALREDEIA
CCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
CRSLGLSPTKIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFVESAFVLAIVVLGGMG
HHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
SQFAVILAAVLLVVSRELMRDLNAYSMLLLGALMVLMMIWRPQGLLPMKRPQLKLKVADV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
KAKQGEQA
CCCCCCCC
>Mature Secondary Structure
MKQLNFVNAIISSFVLLVLASFVMGLQLQLDGTRLVVQGASEVRWLWIGAGCLVVFCFQL
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHH
VRPLIQQGIKKVSGPAWVLPSFDGTTPRQKLLAAVVIIAAVAWPFLVSRGSVDIATLTLI
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
YVMLGLGLNVVVGLSGLLVLGYGGFYAIGAYTYALLNHYYGLGFWESLPLAGITAALSGF
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
LLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAK
HHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEECCCCCCCCC
DGGWDTFHNFFGLTYDPSHRIIFLYLVALLLVILTLFVINRLLRMPLGRAWEALREDEIA
CCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
CRSLGLSPTKIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFVESAFVLAIVVLGGMG
HHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
SQFAVILAAVLLVVSRELMRDLNAYSMLLLGALMVLMMIWRPQGLLPMKRPQLKLKVADV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
KAKQGEQA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]