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The map label for this gene is ubiE [H]

Identifier: 218930783

GI number: 218930783

Start: 4243465

End: 4244220

Strand: Reverse

Name: ubiE [H]

Synonym: YPO3781

Alternate gene names: 218930783

Gene position: 4244220-4243465 (Counterclockwise)

Preceding gene: 218930784

Following gene: 218930782

Centisome position: 91.2

GC content: 44.84

Gene sequence:

>756_bases
ATGGTAGATCAGGAGAAGGAAACCACCCATTTTGGTTTTCGCACCGTAGCCAAAGAACAGAAAGAAGGCATGGTGGCAGA
AGTTTTTCATTCCGTAGCAGCTAAATACGATCTAATGAATGACCTGATGTCATTTGGTGTTCATCGTATTTGGAAGCGTT
TTACGGTTGACTGTAGCGGTGTCCGTCGTGGTCAACGCGTGTTGGATTTAGCTGGCGGTACTGGCGATCTGACAGCTAAA
TTCTCCCGTTTAGTGGGTGAACAGGGTGAAGTCATCCTGGCTGATATCAATGAATCCATGTTACGGATGGGGCGTGAAAA
ACTCCGTGATAAAGGTATTGTAGGTAATGTCAGCTATGTACAGGCCAATGCTGAAGCTTTACCTTTCCCTGATAATTTTT
TTGACTGTATTACCATTTCATTCGGTTTGAGAAATGTCACCGAAAAAGAAAAGGCATTGCGTTCTATGTTTCGGGTGCTG
AAGCCAGGTGGGCGTCTGCTAGTTCTTGAGTTTTCTAAGCCGCTCCTCGAACCGTTAAGTAAAGCCTACGATGCCTACTC
CTTCCATATCTTGCCTAAAATTGGTGAGCTTGTGGCTCAGGACGCTGAAAGTTATCGCTATCTGGCAGAATCTATTCGGA
TGCATCCTGATCAAGAAACACTAAAAGGTATGATGGCCGACGCTGGGTTTGAAAACGTAACCTATTCCAATTTAACCGGT
GGCATTGTTGCGTTACATCGGGGCTTTAAGTTCTAA

Upstream 100 bases:

>100_bases
CCAGAGTAATTTAATTGGCACCGCAACCAGGGGGTGTGGGGCTTTCATCGGAGTTCTGGTACACTTCCTCGAAAGATTGA
CTGAAAAGCAGGCATAGAAA

Downstream 100 bases:

>100_bases
CAGGAATATGGCTATGTCACTAAGAACACTAATGCTAAAGCCCTTTTTATTAAAACCAAGGTTACTGACACCCCTAATAA
CCGCAGCCTTAGAAACGGTT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MVDQEKETTHFGFRTVAKEQKEGMVAEVFHSVAAKYDLMNDLMSFGVHRIWKRFTVDCSGVRRGQRVLDLAGGTGDLTAK
FSRLVGEQGEVILADINESMLRMGREKLRDKGIVGNVSYVQANAEALPFPDNFFDCITISFGLRNVTEKEKALRSMFRVL
KPGGRLLVLEFSKPLLEPLSKAYDAYSFHILPKIGELVAQDAESYRYLAESIRMHPDQETLKGMMADAGFENVTYSNLTG
GIVALHRGFKF

Sequences:

>Translated_251_residues
MVDQEKETTHFGFRTVAKEQKEGMVAEVFHSVAAKYDLMNDLMSFGVHRIWKRFTVDCSGVRRGQRVLDLAGGTGDLTAK
FSRLVGEQGEVILADINESMLRMGREKLRDKGIVGNVSYVQANAEALPFPDNFFDCITISFGLRNVTEKEKALRSMFRVL
KPGGRLLVLEFSKPLLEPLSKAYDAYSFHILPKIGELVAQDAESYRYLAESIRMHPDQETLKGMMADAGFENVTYSNLTG
GIVALHRGFKF
>Mature_251_residues
MVDQEKETTHFGFRTVAKEQKEGMVAEVFHSVAAKYDLMNDLMSFGVHRIWKRFTVDCSGVRRGQRVLDLAGGTGDLTAK
FSRLVGEQGEVILADINESMLRMGREKLRDKGIVGNVSYVQANAEALPFPDNFFDCITISFGLRNVTEKEKALRSMFRVL
KPGGRLLVLEFSKPLLEPLSKAYDAYSFHILPKIGELVAQDAESYRYLAESIRMHPDQETLKGMMADAGFENVTYSNLTG
GIVALHRGFKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=286, Percent_Identity=44.0559440559441, Blast_Score=241, Evalue=6e-64,
Organism=Escherichia coli, GI48994983, Length=251, Percent_Identity=83.2669322709163, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=47.3469387755102, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323526, Length=261, Percent_Identity=39.8467432950192, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24641702, Length=260, Percent_Identity=45.3846153846154, Blast_Score=241, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28183; Mature: 28183

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQEKETTHFGFRTVAKEQKEGMVAEVFHSVAAKYDLMNDLMSFGVHRIWKRFTVDCSG
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VRRGQRVLDLAGGTGDLTAKFSRLVGEQGEVILADINESMLRMGREKLRDKGIVGNVSYV
HHCCHHHEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFPDNFFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPLLEPLS
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
KAYDAYSFHILPKIGELVAQDAESYRYLAESIRMHPDQETLKGMMADAGFENVTYSNLTG
HHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
GIVALHRGFKF
HHHHHHCCCCC
>Mature Secondary Structure
MVDQEKETTHFGFRTVAKEQKEGMVAEVFHSVAAKYDLMNDLMSFGVHRIWKRFTVDCSG
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VRRGQRVLDLAGGTGDLTAKFSRLVGEQGEVILADINESMLRMGREKLRDKGIVGNVSYV
HHCCHHHEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFPDNFFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPLLEPLS
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
KAYDAYSFHILPKIGELVAQDAESYRYLAESIRMHPDQETLKGMMADAGFENVTYSNLTG
HHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
GIVALHRGFKF
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA