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The map label for this gene is murB

Identifier: 218930765

GI number: 218930765

Start: 4216624

End: 4217661

Strand: Reverse

Name: murB

Synonym: YPO3760

Alternate gene names: 218930765

Gene position: 4217661-4216624 (Counterclockwise)

Preceding gene: 218930766

Following gene: 218930764

Centisome position: 90.63

GC content: 43.55

Gene sequence:

>1038_bases
ATGTCGAATCAGCGTTCCTCTCTAAAACACCTTAATACCTTTGCGCTACCTGCTTATGCAAGCAATGTCATTAGTGCTGG
CTCAGTAGAAACATTAATTGCGGCTTGGCATGAATCAAAAGCCAAGCGACAGCCGGTACTATTACTAGGTGAAGGTAGCA
ATGTGTTATTTATTAAAAATTTCTCTGGGACAGTATTACTCAATAGGATTATGGGGATTACTTCTACCGAAGACAGTGCT
GCTTGGTATTTACATGTCGGTGCTGGGGAAAATTGGCATCAACTGGTATGTCATTCACTGCAAAATAATATGCCGGGGTT
GGAAAATTTAGCGTTAATTCCAGGCTGTGTCGGCTCTGCGCCGATCCAAAATATAGGTGCCTATGGCGTTGAATTAAAAC
AAGTATGTGAATATGTTGATTTACTTGATATGGATAAAGGTACTATTCAGCGTATCTCCGCTGAGGAGTGTCAGTTTGGT
TACCGTGACAGCATTTTTAAACATCGCTATGGGAATGGATTTGCTATCGTATCTGTCGGTATTAAATTGATGAAATCATG
GACTCCAACGCTGGGTTATGGCGACTTAATACATATGGACCCATTAACAGTTACTGCCACAGATATTTTTAACTCTGTCT
GTACAATGCGGCGGAGTAAACTTCCAGACCCAATGGTCACTGGCAATGCCGGGAGTTTCTTCAAAAACCCTGTAGTAAGC
GCAGCAATCGCTGAGGAGATCGTACATTGTTACCCCAATGCTCCTCATTATCTGCAGCCAGATGGGTCAGTAAAACTTGC
AGCAGGTTGGTTGATCGATCAGTGTTCACTTAAGGGGTACCAGATTGGTGGTGCCGCAGTACACCAGCAACAAGCTCTGG
TGCTGATTAACCAGTCAGAAGCGACTGGCCAAGATGTAATACATCTTGCACGTTATATCCGCCAGCAGGTCGCACAGAGA
TTTTCAATCTGGCTAGAACCAGAGGTACGCTTTATTGCTGATAATGGTGAAGTTAATGCTGTGGAGCATTTATCGTGA

Upstream 100 bases:

>100_bases
TCACTACTTTTTCATTATTTACTTGAAATAAAAAATACAAACAGCCCATTACGATCGGTTAGACTAGCGCGAGAGTTATT
TAGAATGAGCATCTAATGTA

Downstream 100 bases:

>100_bases
AAGATATCAGGGTCCCCTTACGGTTAGTCAGTATATTATCTGATGGTTTTTTTCACTCCGGTGAGCAATTGGGTGAAACG
TTAGGCATGAGTCGCGCTGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSA
AWYLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFG
YRDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQR
FSIWLEPEVRFIADNGEVNAVEHLS

Sequences:

>Translated_345_residues
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSA
AWYLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFG
YRDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQR
FSIWLEPEVRFIADNGEVNAVEHLS
>Mature_344_residues
SNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSAA
WYLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGY
RDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVSA
AIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQRF
SIWLEPEVRFIADNGEVNAVEHLS

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=339, Percent_Identity=61.9469026548673, Blast_Score=451, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_YERPE (Q8ZAN4)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0457
- RefSeq:   NP_667808.1
- RefSeq:   NP_994578.1
- RefSeq:   YP_002348640.1
- ProteinModelPortal:   Q8ZAN4
- SMR:   Q8ZAN4
- GeneID:   1145417
- GeneID:   1176590
- GeneID:   2764500
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3760
- KEGG:   ypk:y0471
- KEGG:   ypm:YP_3288
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   YPES187410:Y0471-MONOMER
- BioCyc:   YPES214092:YPO3760-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 37768; Mature: 37636

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 162-162 ACT_SITE 232-232 ACT_SITE 328-328

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKN
CCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
FSGTVLLNRIMGITSTEDSAAWYLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSA
CCCHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCC
PIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGYRDSIFKHRYGNGFAIVSVG
CHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCCHHHHHHHHCCCCEEEHHHH
IKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
HHHHHHCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHCCCCCEEECCCCCHHHCHHHH
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSE
HHHHHHHHHHCCCCCCEECCCCCEEEEECEEEECCCCCCEEECCHHHCCCCEEEEEECCC
ATGQDVIHLARYIRQQVAQRFSIWLEPEVRFIADNGEVNAVEHLS
CCHHHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKN
CCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
FSGTVLLNRIMGITSTEDSAAWYLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSA
CCCHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCC
PIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGYRDSIFKHRYGNGFAIVSVG
CHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCCHHHHHHHHCCCCEEEHHHH
IKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
HHHHHHCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHCCCCCEEECCCCCHHHCHHHH
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSE
HHHHHHHHHHCCCCCCEECCCCCEEEEECEEEECCCCCCEEECCHHHCCCCEEEEEECCC
ATGQDVIHLARYIRQQVAQRFSIWLEPEVRFIADNGEVNAVEHLS
CCHHHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430