Click here to switch to the map view.

The map label for this gene is aceK [H]

Identifier: 218930729

GI number: 218930729

Start: 4167989

End: 4169716

Strand: Reverse

Name: aceK [H]

Synonym: YPO3724

Alternate gene names: 218930729

Gene position: 4169716-4167989 (Counterclockwise)

Preceding gene: 218930730

Following gene: 218930728

Centisome position: 89.6

GC content: 46.41

Gene sequence:

>1728_bases
ATGGTGGCAAAGCTAGAACAACTTATCGCTCAGACCATTTTGCAGGGATTTGATGCGCAATATGGCCGTTTTCTGGAGGT
CACTGCCGGTGCTCAACACCGTTTTGAGCAGGCCGATTGGCATGCGGTACAGCAGGCGATGAAAAAGCGTATTCACCTTT
ATGATCACCATGTGGGTTTAGTGGTTGAGCAACTGAAATACATTACGGATCAACGCCATTTTGATGTGGAATTTTTGGCG
CGGGTGAAAGAAATTTATACCGGGCTGCTACCGGATTATCCGCGCTTCGAAATCGCCGAAAGCTTTTTTAATTCGGTTTA
TTGCCGTTTATTTAAACACCGCGATTTAACGCCCGATAAGTTGTTTGTTTTTAGCTCTCAGCCTGAGCGGCGCTTCCGTG
AGATCCCACGGCCTCTGGCCCGCGATTTCATCCCTAAAGGGGATCTCAGTGGTATGTTGCAGATGGTGCTTAATGATTTA
TCACTGCGCTTACATTGGGAAAATTTGTCGCGAGACATTGATTATATCGTGATGGCCATACGGCAAGCCTTTACCGATGA
GCAGCTAGCCAGTGCGCATTTTCAAATAGCGAATGAGTTGTTTTACCGCAATAAGGCCGCTTGGTTGGTGGGTAAATTGA
GGCTGAACGGTGACATCTATCCTTTCTTGTTACCTATTCATCACAATGAGTCTGGTGAGCTATTTATTGATACCTGTCTG
ACCAGCAAAGCGGAGGCCAGTATCGTGTTCGGCTTCGCTCGTTCTTATTTTATGGTCTATGTGCCGCTGCCGGCTGCAAT
GGTGGAATGGTTACGGGAAATATTACCGGGTAAATCTACCGCTGAGCTGTATACGGCGATTGGCTGTCAGAAACACGGTA
AAACAGAGAGTTATCGCGAGTATTTGGCTTTTATTCATCAATCCAGTGAACAGTTTATTATTGCACCTGGGGTGAAAGGC
ATGGTGATGTTGGTCTTTACCTTACCGTCATTTGATCGGGTATTTAAGGTGATTAAAGACCAATTTGCACCACAAAAAGA
GGTCACTCAAGCACGAGTTTTAGAATGCTATCAATTAGTTAAAGAACATGACCGGGTAGGGCGCATGGCGGATACCCAAG
AGTATGAAAATTTTGTGATTGATAAGCACCGTATCAGCCCAGAACTGCTGGCGGAGTTGCAACATGAAGTACCCGAAAAA
CTGGAGGATTTAGGTGACAAGATCGTCATTAAGCACCTGTATATGGAGCGAAGGATGACCCCGTTAAATCTCTATATGGA
GCAGGCAGATGATCAGCAGTTGAAGGATGCTATTGAGGAATATGGTAACGCCATTAAACAACTGGCTGCGGCCAATATTT
TCCCCGGTGATATGTTATTTAAGAACTTCGGTGTGACGCGCCATGGGCGGGTGGTGTTCTACGATTATGATGAAATTTGT
TATATGACCGAGGTTAATTTCCGCGATATTCCCCCACCGCGTTATCCCGAAGATGAGATGGCCAGTGAGCCGTGGTACAG
CGTGTCTCCTAATGATGTTTTTCCCGAAGAGTTTCGCCATTTCTTATGCAGTGACCGGAAAGTCAGGCACTTTTTTGAGG
AGATGCACGGCGATCTGTTCCAGGCCAGTTATTGGCGCGGCTTGCAGCAGCGTATCCGGGATGGGCATGTGGAGGATGTT
TTTGCTTATAGACGAAAGCAACGCTTCTCCCAGCGGGCTTTAAATTAA

Upstream 100 bases:

>100_bases
TACGGCGTCTTTACGATCTGCCTGTTCTCTCCGTCGCGGGCACTTTGTCAATAACCTCAGCCTGCTTATGCAGGCTCCGT
TTTGTACGGTAGGGGGCAGC

Downstream 100 bases:

>100_bases
CGGCGACTGCGCGCTGAACGTACTCAGATTAACGTAGCTCGCTACGCCTCTATTTATCGCGTCTTTACGATCGGCCTGTT
CTCGCCGAACGACAAATTTT

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLA
RVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDL
SLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCL
TSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKG
MVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEK
LEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDV
FAYRRKQRFSQRALN

Sequences:

>Translated_575_residues
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLA
RVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDL
SLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCL
TSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKG
MVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEK
LEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDV
FAYRRKQRFSQRALN
>Mature_575_residues
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLA
RVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDL
SLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCL
TSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKG
MVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEK
LEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDV
FAYRRKQRFSQRALN

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=572, Percent_Identity=75.1748251748252, Blast_Score=909, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 67623; Mature: 67623

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGL
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLHWENLSRDIDYIVMAI
EEEECCCHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHH
RQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCL
HHHHCHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCEEEEEEEEEECCCCCEEEEEHH
TSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYRE
CCCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHH
YLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLV
HHHHHHCCCCCEEECCCCCCEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMT
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLF
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHH
QASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGL
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLHWENLSRDIDYIVMAI
EEEECCCHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHH
RQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCL
HHHHCHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCEEEEEEEEEECCCCCEEEEEHH
TSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYRE
CCCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHH
YLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLV
HHHHHHCCCCCEEECCCCCCEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMT
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLF
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHH
QASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA