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The map label for this gene is pyrB [H]

Identifier: 218930598

GI number: 218930598

Start: 3996574

End: 3997509

Strand: Direct

Name: pyrB [H]

Synonym: YPO3588

Alternate gene names: 218930598

Gene position: 3996574-3997509 (Clockwise)

Preceding gene: 218930597

Following gene: 218930599

Centisome position: 85.88

GC content: 48.4

Gene sequence:

>936_bases
ATGGCCAATCCGTTGTATCACAAACATATCATCTCAATTAACGATTTAAGTCGCGATGAACTAGAACTGGTCTTGCGTAC
TGCGGCCAGCCTGAAAAAGACTCCGCAGCCAGAGTTGTTAAAACATAAAGTGATCGCCAGTTGCTTTTTTGAAGCGTCGA
CCCGCACCCGCTTGTCATTTGAAACATCCATTCACCGCCTGGGTGCCTCGGTCGTGGGCTTTTCTGATAGCAGCAATACC
TCATTGGGTAAGAAAGGCGAGACACTGGCAGACACCATGTCAGTCATTAGCACTTATGTTGACGCCATTGTGATGCGCCA
TCCACAAGAAGGGGCTTCACGTCTGGCCGCGCAATTCTCGGGGAATGTGCCTATCGTGAATGCCGGTGACGGCGCAAACC
AGCACCCAACACAAACCCTGCTCGATTTATTCACTATTCAGGAAACGCAGGGCCGGCTGGATAACATCAATATCGCCATG
GTAGGTGACCTGAAATATGGCCGTACCGTGCATTCATTGACGCAAGCGCTGGCAAAATTCAATGGCAACCACTTCTTCTT
TATCGCCCCTGATGCGCTGGCAATGCCCGCTTATATTTTGCAAATGTTGGAAGAAAAAGAGATTGAGTACAGCCTGCATG
AAAGCCTCGAAGAGGTGGTACCGGAGTTAGATATTCTCTATATGACTCGCGTACAGAAAGAGCGCCTTGACCCATCGGAA
TATGCCAATGTCAAAGCACAGTTTATTTTGCGCTCTTCTGATTTAACGGGCGCACGGGATAATCTTAAAGTGTTGCACCC
GCTGCCACGTATTGACGAAATCACAACCGATGTCGATAAAACCCCCTACGCCTACTATTTCCAACAAGCGGGTAACGGTA
TTTTTGCACGTCAGGCGCTACTGGCACTGGTATTAAACGCAGAATTAGCTCTTTAA

Upstream 100 bases:

>100_bases
GGGCTTTTTTTTGTCTGTCGAACAGAACCAAGTTAAGCATTACGACTCATTAAAATAAGGGTAGCCCGCGACCACGGGTA
AGCACAGAGGAGAGCAAAAA

Downstream 100 bases:

>100_bases
GGGGAATGATGATGACTCAGGATTACAAACTTCAGGTTGAAGCGATTAAATGCGGCACCGTGATTGACCATATTCCAGCT
CAAATCGGCTTTAAATTGCT

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MANPLYHKHIISINDLSRDELELVLRTAASLKKTPQPELLKHKVIASCFFEASTRTRLSFETSIHRLGASVVGFSDSSNT
SLGKKGETLADTMSVISTYVDAIVMRHPQEGASRLAAQFSGNVPIVNAGDGANQHPTQTLLDLFTIQETQGRLDNINIAM
VGDLKYGRTVHSLTQALAKFNGNHFFFIAPDALAMPAYILQMLEEKEIEYSLHESLEEVVPELDILYMTRVQKERLDPSE
YANVKAQFILRSSDLTGARDNLKVLHPLPRIDEITTDVDKTPYAYYFQQAGNGIFARQALLALVLNAELAL

Sequences:

>Translated_311_residues
MANPLYHKHIISINDLSRDELELVLRTAASLKKTPQPELLKHKVIASCFFEASTRTRLSFETSIHRLGASVVGFSDSSNT
SLGKKGETLADTMSVISTYVDAIVMRHPQEGASRLAAQFSGNVPIVNAGDGANQHPTQTLLDLFTIQETQGRLDNINIAM
VGDLKYGRTVHSLTQALAKFNGNHFFFIAPDALAMPAYILQMLEEKEIEYSLHESLEEVVPELDILYMTRVQKERLDPSE
YANVKAQFILRSSDLTGARDNLKVLHPLPRIDEITTDVDKTPYAYYFQQAGNGIFARQALLALVLNAELAL
>Mature_310_residues
ANPLYHKHIISINDLSRDELELVLRTAASLKKTPQPELLKHKVIASCFFEASTRTRLSFETSIHRLGASVVGFSDSSNTS
LGKKGETLADTMSVISTYVDAIVMRHPQEGASRLAAQFSGNVPIVNAGDGANQHPTQTLLDLFTIQETQGRLDNINIAMV
GDLKYGRTVHSLTQALAKFNGNHFFFIAPDALAMPAYILQMLEEKEIEYSLHESLEEVVPELDILYMTRVQKERLDPSEY
ANVKAQFILRSSDLTGARDNLKVLHPLPRIDEITTDVDKTPYAYYFQQAGNGIFARQALLALVLNAELAL

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=313, Percent_Identity=43.7699680511182, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI38788445, Length=316, Percent_Identity=26.8987341772152, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI2367364, Length=311, Percent_Identity=84.887459807074, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1790703, Length=292, Percent_Identity=29.7945205479452, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786469, Length=296, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=324, Percent_Identity=37.962962962963, Blast_Score=201, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=318, Percent_Identity=38.9937106918239, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6322373, Length=332, Percent_Identity=27.4096385542169, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642586, Length=316, Percent_Identity=42.0886075949367, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 34560; Mature: 34429

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPLYHKHIISINDLSRDELELVLRTAASLKKTPQPELLKHKVIASCFFEASTRTRLSF
CCCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHH
ETSIHRLGASVVGFSDSSNTSLGKKGETLADTMSVISTYVDAIVMRHPQEGASRLAAQFS
HHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GNVPIVNAGDGANQHPTQTLLDLFTIQETQGRLDNINIAMVGDLKYGRTVHSLTQALAKF
CCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
NGNHFFFIAPDALAMPAYILQMLEEKEIEYSLHESLEEVVPELDILYMTRVQKERLDPSE
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
YANVKAQFILRSSDLTGARDNLKVLHPLPRIDEITTDVDKTPYAYYFQQAGNGIFARQAL
HHCCEEEEEEECCCCCCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
LALVLNAELAL
HHHHHHHHHCC
>Mature Secondary Structure 
ANPLYHKHIISINDLSRDELELVLRTAASLKKTPQPELLKHKVIASCFFEASTRTRLSF
CCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHH
ETSIHRLGASVVGFSDSSNTSLGKKGETLADTMSVISTYVDAIVMRHPQEGASRLAAQFS
HHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GNVPIVNAGDGANQHPTQTLLDLFTIQETQGRLDNINIAMVGDLKYGRTVHSLTQALAKF
CCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
NGNHFFFIAPDALAMPAYILQMLEEKEIEYSLHESLEEVVPELDILYMTRVQKERLDPSE
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
YANVKAQFILRSSDLTGARDNLKVLHPLPRIDEITTDVDKTPYAYYFQQAGNGIFARQAL
HHCCEEEEEEECCCCCCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
LALVLNAELAL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA