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The map label for this gene is lptA [H]

Identifier: 218930592

GI number: 218930592

Start: 3991124

End: 3991669

Strand: Direct

Name: lptA [H]

Synonym: YPO3580

Alternate gene names: 218930592

Gene position: 3991124-3991669 (Clockwise)

Preceding gene: 218930591

Following gene: 218930593

Centisome position: 85.76

GC content: 44.32

Gene sequence:

>546_bases
ATGAAATCCAAAAATAAAATAAGTCATCTTTTACTTGCCTGCTCACTTTTAGCCGCAAGCCTGTCTGCATTCGCATTAAC
TGGCGATACAGAACAACCTGCCGAGGTCAAATCCGACAAACAAACATTGGATATGGAAACCAATACGGTCACCTTTATTG
ATAACGTGGTGATCAAACAAGGCACGATCGAGATCAAAGCCGATAAAGTGGTCGTCACGCGCCCCGGTGGCGATCAAAGT
AAAATGATCATTGAAGGCTTTGGTAATCCAGTCACCTTCTACCAGATGCAAGATAGCGGTAAACCGGTAAAAGGCCATGG
GCAGAAATTACGTTACGAAATCGCTAACGACTTTGTGGTACTGACCGGCGATGCCTATCTGGAACAGCTCGATAGCAATA
TCAAAGGCGATCGCATCACTTATTTGGTGAAAAAGCAGCAGATGGAAGCCTTTAGTGATAAAGGTAAGCGCGTCACTACC
GTGTTATTACCGTCTCAATTACAAGATAAAGGGCCAGCAGCATCAGGCCAAAAGAAGAGTAAGTAA

Upstream 100 bases:

>100_bases
GTGACCCTTTTCGGTATTGGATTTACCTCTGAAGGCATGAGAATACGTGGGAACTTGCGGGACAAAACCGCTGAGCTGAT
TGAAAAGGTTAAAACCTCTT

Downstream 100 bases:

>100_bases
TCATTTATGGCAACATTAATCGCAGAAAAGCTGGCTAAGGCGTACAAAGGCCGTAAAGTGGTCGAAGACGTTAGCCTAAA
CGTGAAGTCTGGGGAAATTG

Product: lipopolysaccharide transport periplasmic protein LptA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQGTIEIKADKVVVTRPGGDQS
KMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVVLTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTT
VLLPSQLQDKGPAASGQKKSK

Sequences:

>Translated_181_residues
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQGTIEIKADKVVVTRPGGDQS
KMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVVLTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTT
VLLPSQLQDKGPAASGQKKSK
>Mature_181_residues
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQGTIEIKADKVVVTRPGGDQS
KMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVVLTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTT
VLLPSQLQDKGPAASGQKKSK

Specific function: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain

COG id: COG1934

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptA family [H]

Homologues:

Organism=Escherichia coli, GI1789592, Length=172, Percent_Identity=69.7674418604651, Blast_Score=252, Evalue=1e-68,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014340
- InterPro:   IPR005653 [H]

Pfam domain/function: PF03968 OstA [H]

EC number: NA

Molecular weight: Translated: 19794; Mature: 19794

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQ
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHCCCCCEECCCCCEEEEEEEEEEEC
GTIEIKADKVVVTRPGGDQSKMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVV
CEEEEEECEEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCEEEEEECCCEEE
LTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTTVLLPSQLQDKGPAASGQKKS
EECHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCCCCCC
K
C
>Mature Secondary Structure
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQ
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHCCCCCEECCCCCEEEEEEEEEEEC
GTIEIKADKVVVTRPGGDQSKMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVV
CEEEEEECEEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCEEEEEECCCEEE
LTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTTVLLPSQLQDKGPAASGQKKS
EECHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]