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The map label for this gene is fadE

Identifier: 218930271

GI number: 218930271

Start: 3609497

End: 3611944

Strand: Direct

Name: fadE

Synonym: YPO3244

Alternate gene names: 218930271

Gene position: 3609497-3611944 (Clockwise)

Preceding gene: 218930268

Following gene: 218930277

Centisome position: 77.56

GC content: 51.51

Gene sequence:

>2448_bases
ATGATAGTTCTTAGCATTATTGCCTTACTGGTTCTTATTAGTGTGTTGTTCTATCACCGGGTGAACCTTTATCTCAGCAG
TTTAATTCTTCTGGTTTACACCGCCGCTTTGAGCGCATCGCAGTTATGGTCATTCTGGGTATTATTGCCACTGGTGATTA
TGCTGTTGCCACTGATCCTAACGCCGCTGCGCAAGTCACTGTTTTCTGCGCCAGCATTACGGATTTTCCGTAGCGTCATG
CCTGCTATGTCGCGTACAGAAAAAGAAGCGATCGATGCAGGGACTACCTGGTGGGAAGGTGATTTGTTCCGAGGGGCTCC
TGACTGGAAAAAATTACATAACTATCCAAAACCGCAATTAACCGCCGAAGAGCAAGCCTTTATCGATGGGCCGGTTGAAG
AAGCCTGCCGTATGGCTAATGACTTCCAGATAACCCATGAACTGGCTGATTTGCCACCAGAATTATGGGATTACCTGAAA
GAAAAACGCTTCTTCGCGATGATCATTAAGAAAGAATATGGTGGCCTTGAGTTTTCTGCTTATGCTCAGGCCCGCGTGTT
ACAGAAACTAGCTGGGGTCTCAGGTATTCTGGCCATCACCGTTGGCGTGCCAAATTCCCTTGGCCCAGGTGAATTACTGC
AACATTACGGCACTGAAGAGCAAAAAAATCATTATCTGCCAAGATTAGCCCGGGGTGACGAGATCCCTTGTTTTGCACTA
ACCAGCCCGGAAGCTGGTTCTGATGCCGGTGCGATCCCTGATGTTGGTATTGTCTGTATGGGCGAGTGGCAAGGTAAACA
GGTTCTCGGCATGCGCCTAACCTGGAACAAGCGCTATATTACGCTGGCCCCCATCGCGACGGTTCTGGGGCTGGCCTTCA
AATTATCGGACCCCGAACACTTACTGGGCGATACGGTAGACTTGGGGATTACCTGTGCACTGATCCCAACCCATACACCA
GGAGTAGAGATCGGGCATCGTCACTTCCCGCTCAATATACCGTTCCAAAATGGCCCTACCCGTGGTAACGATATTTTTGT
CCCCATTGATTACATCATCGGCGGCCCTCAAATGGCCGGTCAAGGCTGGCGGATGCTGGTGGAATGCCTGTCTGTGGGGC
GTGGAATCACCTTGCCTTCCAATGCCACTGGTAGCCTGAAAAGTGTGGCGATGGGGATCGGTGCTTACGCTTATATTCGC
CGTCAATTCAAAATCTCCATCGGTAAGATGGAGGGGATTGAAGAGCCACTGGCGCGGATCGCCGGTAACACTTATGTGAT
GGATGCAGCCGCAACCTTAATCACCAGCGGCATTATGATGGGCGAGAAACCAGCCGTCTTGTCTGCCATTGTTAAATATC
ACTGTACACACCGTGGTCAACGCGCCGTGATGGATGCCATGGATATCGCCGGTGGTAAAGGGATCTGTCTTGGCCCCGCT
AACTTTGTCGCCCGTGGTTATCAGGGCGCACCCATCGGTATCACTGTCGAAGGCGCAAATATTCTGACCCGTAGTATGAT
TATCTTTGGTCAGGGTGCTATCCGTTGCCATCCATTTGTTCTCGATGAGATGGCGGCTGCGCAATCCAATGACGTTGCCG
CTTTCGATAAAGCCCTGTTTGGTCACTTGGGCCACGTCGGTAGTAGTATGGTACGCAGCTTCTGGCTGGGCCTGACCAAT
GGCCGCACCAGTGCAACACCAGTCAAAGACAGCACCCGGCGTTATTATCAACAGCTAAACCGTCTGAGCGCTAACTTGGC
CTTGCTGTCTGATGTTTCAATGGGCGTGCTGGGTGGTAGCCTAAAACGTCGCGAACGTATCTCTGCCCGTTTGGGTGATA
TCCTCAGCCAACTGTATTTAGCATCCGCCACACTGAAACGCTATGAAGATGAAGGCCGTCAGAAAGAGGATCTGCCGTTG
GTACATTGGGGGGTACAAGATGCTCTGTATCAGGCCGAACAAGCACTGGATGACTTGCTGCGTAACTTCCCGAATAGCGT
GATTGCTGGATTGATGCGTGTCGTGGTCTTCCCATTGGGCCGTGTACATCGGGCACCGTCCGATCATCTGGATCACCAGT
TGGCGCAATTGCTACAAGTTCCATCAGCCACCCGTAGCCGTATCGGCCGTGGTCAGTACCTGACGCCAAGTGAATTTAAC
CCGGTAGGGTTATTGGAAGCGGCCTTGCTGGATGTGATTGCCGCAGAACCGATTCACAAACGCCTGAGTAAAGAAGCGGG
TAAGAGCCTGCCCTTTACTCGCTTGGATCAGTTAGCTAAACACGCCTTGGCAGAAGGGAAAATCAGCGCCGAAGAGGCCG
CGTTGCTGACTAAAGCAGAAAACAGCCGCCTGCGTTCTATTAATGTGGATGAGTTTGACGCCAGCGCCTTGGCAGCAAAC
CCAGTAGTCAAAAAACCGGCTAAACAGCAGCAAACTGAAGCCGCATGA

Upstream 100 bases:

>100_bases
TTGTAAATAACATGTAATTTTATTGATAAAAAGAATGAGATGAACTAAAACAAATGTATCACTCAACAGGTCAGACCTCC
TACATCTCAGGAGCTTCATT

Downstream 100 bases:

>100_bases
TGTATCCAGCTTATTTATAATCAGTATCGAAATAATCAACCAAGCCTCCCATTAAGGAGGCTTAGTTTTATGTTTAATAA
AAAAATACTTAATTCAGCGA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MIVLSIIALLVLISVLFYHRVNLYLSSLILLVYTAALSASQLWSFWVLLPLVIMLLPLILTPLRKSLFSAPALRIFRSVM
PAMSRTEKEAIDAGTTWWEGDLFRGAPDWKKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWDYLK
EKRFFAMIIKKEYGGLEFSAYAQARVLQKLAGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGDEIPCFAL
TSPEAGSDAGAIPDVGIVCMGEWQGKQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEHLLGDTVDLGITCALIPTHTP
GVEIGHRHFPLNIPFQNGPTRGNDIFVPIDYIIGGPQMAGQGWRMLVECLSVGRGITLPSNATGSLKSVAMGIGAYAYIR
RQFKISIGKMEGIEEPLARIAGNTYVMDAAATLITSGIMMGEKPAVLSAIVKYHCTHRGQRAVMDAMDIAGGKGICLGPA
NFVARGYQGAPIGITVEGANILTRSMIIFGQGAIRCHPFVLDEMAAAQSNDVAAFDKALFGHLGHVGSSMVRSFWLGLTN
GRTSATPVKDSTRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQLYLASATLKRYEDEGRQKEDLPL
VHWGVQDALYQAEQALDDLLRNFPNSVIAGLMRVVVFPLGRVHRAPSDHLDHQLAQLLQVPSATRSRIGRGQYLTPSEFN
PVGLLEAALLDVIAAEPIHKRLSKEAGKSLPFTRLDQLAKHALAEGKISAEEAALLTKAENSRLRSINVDEFDASALAAN
PVVKKPAKQQQTEAA

Sequences:

>Translated_815_residues
MIVLSIIALLVLISVLFYHRVNLYLSSLILLVYTAALSASQLWSFWVLLPLVIMLLPLILTPLRKSLFSAPALRIFRSVM
PAMSRTEKEAIDAGTTWWEGDLFRGAPDWKKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWDYLK
EKRFFAMIIKKEYGGLEFSAYAQARVLQKLAGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGDEIPCFAL
TSPEAGSDAGAIPDVGIVCMGEWQGKQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEHLLGDTVDLGITCALIPTHTP
GVEIGHRHFPLNIPFQNGPTRGNDIFVPIDYIIGGPQMAGQGWRMLVECLSVGRGITLPSNATGSLKSVAMGIGAYAYIR
RQFKISIGKMEGIEEPLARIAGNTYVMDAAATLITSGIMMGEKPAVLSAIVKYHCTHRGQRAVMDAMDIAGGKGICLGPA
NFVARGYQGAPIGITVEGANILTRSMIIFGQGAIRCHPFVLDEMAAAQSNDVAAFDKALFGHLGHVGSSMVRSFWLGLTN
GRTSATPVKDSTRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQLYLASATLKRYEDEGRQKEDLPL
VHWGVQDALYQAEQALDDLLRNFPNSVIAGLMRVVVFPLGRVHRAPSDHLDHQLAQLLQVPSATRSRIGRGQYLTPSEFN
PVGLLEAALLDVIAAEPIHKRLSKEAGKSLPFTRLDQLAKHALAEGKISAEEAALLTKAENSRLRSINVDEFDASALAAN
PVVKKPAKQQQTEAA
>Mature_815_residues
MIVLSIIALLVLISVLFYHRVNLYLSSLILLVYTAALSASQLWSFWVLLPLVIMLLPLILTPLRKSLFSAPALRIFRSVM
PAMSRTEKEAIDAGTTWWEGDLFRGAPDWKKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWDYLK
EKRFFAMIIKKEYGGLEFSAYAQARVLQKLAGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGDEIPCFAL
TSPEAGSDAGAIPDVGIVCMGEWQGKQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEHLLGDTVDLGITCALIPTHTP
GVEIGHRHFPLNIPFQNGPTRGNDIFVPIDYIIGGPQMAGQGWRMLVECLSVGRGITLPSNATGSLKSVAMGIGAYAYIR
RQFKISIGKMEGIEEPLARIAGNTYVMDAAATLITSGIMMGEKPAVLSAIVKYHCTHRGQRAVMDAMDIAGGKGICLGPA
NFVARGYQGAPIGITVEGANILTRSMIIFGQGAIRCHPFVLDEMAAAQSNDVAAFDKALFGHLGHVGSSMVRSFWLGLTN
GRTSATPVKDSTRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQLYLASATLKRYEDEGRQKEDLPL
VHWGVQDALYQAEQALDDLLRNFPNSVIAGLMRVVVFPLGRVHRAPSDHLDHQLAQLLQVPSATRSRIGRGQYLTPSEFN
PVGLLEAALLDVIAAEPIHKRLSKEAGKSLPFTRLDQLAKHALAEGKISAEEAALLTKAENSRLRSINVDEFDASALAAN
PVVKKPAKQQQTEAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family

Homologues:

Organism=Homo sapiens, GI21361497, Length=545, Percent_Identity=26.9724770642202, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI4557235, Length=436, Percent_Identity=24.7706422018349, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4557233, Length=416, Percent_Identity=27.4038461538462, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI76496475, Length=403, Percent_Identity=25.5583126550869, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI87081702, Length=815, Percent_Identity=80.7361963190184, Blast_Score=1380, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=24.9343832020997, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=24.7191011235955, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538396, Length=321, Percent_Identity=23.3644859813084, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=207, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363737, Length=435, Percent_Identity=26.2068965517241, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24666513, Length=362, Percent_Identity=24.585635359116, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADE_YERPE (Q8ZBY6)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0394
- RefSeq:   NP_668276.1
- RefSeq:   NP_992077.1
- RefSeq:   YP_002348146.1
- ProteinModelPortal:   Q8ZBY6
- SMR:   Q8ZBY6
- IntAct:   Q8ZBY6
- GeneID:   1145893
- GeneID:   1176058
- GeneID:   2767002
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3244
- KEGG:   ypk:y0946
- KEGG:   ypm:YP_0688
- HOGENOM:   HBG284757
- OMA:   CVIDAMD
- ProtClustDB:   PRK09463
- BioCyc:   YPES187410:Y0946-MONOMER
- BioCyc:   YPES214092:YPO3244-MONOMER
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396
- Gene3D:   G3DSA:2.40.110.10
- Gene3D:   G3DSA:1.10.540.10
- Gene3D:   G3DSA:1.20.140.10

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974; SSF56645 AcylCoA_dehyd_NM; SSF47203 AcylCoADH_C_like

EC number: NA

Molecular weight: Translated: 88969; Mature: 88969

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLSIIALLVLISVLFYHRVNLYLSSLILLVYTAALSASQLWSFWVLLPLVIMLLPLIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLRKSLFSAPALRIFRSVMPAMSRTEKEAIDAGTTWWEGDLFRGAPDWKKLHNYPKPQL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHCCCCCCC
TAEEQAFIDGPVEEACRMANDFQITHELADLPPELWDYLKEKRFFAMIIKKEYGGLEFSA
CCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
YAQARVLQKLAGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGDEIPCFAL
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHCCCCCCCEEEE
TSPEAGSDAGAIPDVGIVCMGEWQGKQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEH
CCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCCHH
LLGDTVDLGITCALIPTHTPGVEIGHRHFPLNIPFQNGPTRGNDIFVPIDYIIGGPQMAG
HHCCCCCCCEEEEEECCCCCCCCCCCEECCEECCCCCCCCCCCEEEEEHHHEECCCHHCC
QGWRMLVECLSVGRGITLPSNATGSLKSVAMGIGAYAYIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNTYVMDAAATLITSGIMMGEKPAVLSAIVKYHCTHRGQRAVMDAMDIAGGKGICLGPA
CCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCH
NFVARGYQGAPIGITVEGANILTRSMIIFGQGAIRCHPFVLDEMAAAQSNDVAAFDKALF
HHHHCCCCCCCEEEEEECCHHHHHHHHEECCCCCEECHHHHHHHHHCCCCCHHHHHHHHH
GHLGHVGSSMVRSFWLGLTNGRTSATPVKDSTRRYYQQLNRLSANLALLSDVSMGVLGGS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQLYLASATLKRYEDEGRQKEDLPLVHWGVQDALYQAEQALDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHH
RNFPNSVIAGLMRVVVFPLGRVHRAPSDHLDHQLAQLLQVPSATRSRIGRGQYLTPSEFN
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEAALLDVIAAEPIHKRLSKEAGKSLPFTRLDQLAKHALAEGKISAEEAALLTKAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
NSRLRSINVDEFDASALAANPVVKKPAKQQQTEAA
CCCCCCCCCCCCCCHHHHCCCHHCCCCHHHHCCCC
>Mature Secondary Structure
MIVLSIIALLVLISVLFYHRVNLYLSSLILLVYTAALSASQLWSFWVLLPLVIMLLPLIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLRKSLFSAPALRIFRSVMPAMSRTEKEAIDAGTTWWEGDLFRGAPDWKKLHNYPKPQL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHCCCCCCC
TAEEQAFIDGPVEEACRMANDFQITHELADLPPELWDYLKEKRFFAMIIKKEYGGLEFSA
CCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
YAQARVLQKLAGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGDEIPCFAL
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHCCCCCCCEEEE
TSPEAGSDAGAIPDVGIVCMGEWQGKQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEH
CCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCCHH
LLGDTVDLGITCALIPTHTPGVEIGHRHFPLNIPFQNGPTRGNDIFVPIDYIIGGPQMAG
HHCCCCCCCEEEEEECCCCCCCCCCCEECCEECCCCCCCCCCCEEEEEHHHEECCCHHCC
QGWRMLVECLSVGRGITLPSNATGSLKSVAMGIGAYAYIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNTYVMDAAATLITSGIMMGEKPAVLSAIVKYHCTHRGQRAVMDAMDIAGGKGICLGPA
CCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCH
NFVARGYQGAPIGITVEGANILTRSMIIFGQGAIRCHPFVLDEMAAAQSNDVAAFDKALF
HHHHCCCCCCCEEEEEECCHHHHHHHHEECCCCCEECHHHHHHHHHCCCCCHHHHHHHHH
GHLGHVGSSMVRSFWLGLTNGRTSATPVKDSTRRYYQQLNRLSANLALLSDVSMGVLGGS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQLYLASATLKRYEDEGRQKEDLPLVHWGVQDALYQAEQALDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHH
RNFPNSVIAGLMRVVVFPLGRVHRAPSDHLDHQLAQLLQVPSATRSRIGRGQYLTPSEFN
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEAALLDVIAAEPIHKRLSKEAGKSLPFTRLDQLAKHALAEGKISAEEAALLTKAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
NSRLRSINVDEFDASALAANPVVKKPAKQQQTEAA
CCCCCCCCCCCCCCHHHHCCCHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430