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The map label for this gene is purE [H]

Identifier: 218930121

GI number: 218930121

Start: 3431738

End: 3432262

Strand: Direct

Name: purE [H]

Synonym: YPO3076

Alternate gene names: 218930121

Gene position: 3431738-3432262 (Clockwise)

Preceding gene: 218930120

Following gene: 218930122

Centisome position: 73.74

GC content: 55.81

Gene sequence:

>525_bases
ATGGGAGCCAACCTCAATTCAGCTTATGCAGCCGGGGTTAAAATCGCCATCGTAATGGGGTCCAAGAGTGATTGGGCCAC
CATGCAGTTCGCCGCCGACGTTCTCACCACGCTCAATGTTCCGTTTCATGTGGAAGTCGTCTCTGCACACCGCACCCCAG
ATAGGTTGTTCAGCTTTGCCGAACAGGCCGAAGCCAATGGCTTACATGTGATCATTGCCGGTGCCGGTGGTGCAGCACAT
TTGCCAGGGATGCTGGCCGCCAAAACGCTGGTGCCGGTTTTAGGGGTTCCGGTGCAAAGTGCGGCCTTGAGTGGCGTTGA
TAGCCTGTACTCAATTGTGCAAATGCCACGCGGCATTCCTGTAGGGACGCTCGCTATCGGTAAAGCCGGTGCGGCCAATG
CGGCGCTGCTGGCCGCACAAATCTTAGCATTACACGATACTGAATTAGCTGGCCGCTTGGCACATTGGCGTCAAAGTCAA
ACGGATGACGTGCTGGACAACCCTGATCCGAGGGAAGAAGCATGA

Upstream 100 bases:

>100_bases
CGCCTTTGGCTCATGATATGCTCTACGCCCTCTTCGCCAGCCACGATGTATAGTCAGTCGTTCTGGCCGACGCTTGCGCA
ATTACAGGAGCTTTACACCC

Downstream 100 bases:

>100_bases
AACCAGTTTGTGTACTGGGTAATGGCCAGTTAGGGCGAATGCTGCGGCAGGCAGGTGAACCGCTGGGAATTGCGGTTTAT
CCCGTCGGCTTAGATGCTGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFAEQAEANGLHVIIAGAGGAAH
LPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQ
TDDVLDNPDPREEA

Sequences:

>Translated_174_residues
MGANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFAEQAEANGLHVIIAGAGGAAH
LPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQ
TDDVLDNPDPREEA
>Mature_173_residues
GANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFAEQAEANGLHVIIAGAGGAAHL
PGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQT
DDVLDNPDPREEA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=84.8101265822785, Blast_Score=236, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=51.6556291390728, Blast_Score=152, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17952; Mature: 17821

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFA
CCCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
EQAEANGLHVIIAGAGGAAHLPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIP
HHHCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQTDDVLDNPDPREEA
CCEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFA
CCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
EQAEANGLHVIIAGAGGAAHLPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIP
HHHCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQTDDVLDNPDPREEA
CCEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]