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The map label for this gene is tibA [H]

Identifier: 218930073

GI number: 218930073

Start: 3381105

End: 3383384

Strand: Direct

Name: tibA [H]

Synonym: YPO3028

Alternate gene names: 218930073

Gene position: 3381105-3383384 (Clockwise)

Preceding gene: 218930072

Following gene: 218930075

Centisome position: 72.65

GC content: 44.25

Gene sequence:

>2280_bases
TTGAACACCAATAGTAAAAAAACCTACCTTAACATTGCTATTTCATTCATTCTTTACGCCTCAACAGCAATGAACGCAAA
CGCCGATTCATGTATTGATTATACTGTCACTGATATTTGTGAGCAGAGTAAATATGCTGCGGGTGAATTTCATAATATTA
AGCTGGGTGATGGTGTCACTGCTGGTAGCGAAGATCACCATTTTGTCTTTAATGGTGAAGGATATGAATTATACAATTCT
AACGCGAATTTCTCTGCTCAAATTGCCTCAGGTACCATTCGCTATACCGAAGTGAACAACAGTTACTTTACTGTAAACGC
TCACCATTTTCCGGATGATACCATCTATGCCGGCCGTGCAGAAAATACCACATTGAATGATAGCCTGATGTGGGTGGCAA
CATCGGCTGATCAGACACTGGCTAAAGGTAATTCAATGGTCGTTGTTTCCACCCAAATGGCCATGGTTGATCAAATTTTT
GTTACGACGTTGAATGATGGTAGCCTTCCATTTGATCCCGTCATTACCAATAGCCGCTATGAAGATACGTCATATGAAAT
GTTATGGGGTATGAAAAACGAGGCAAAAGGGTGGGATACCAAAGCCACATCGCATGACTCCGTATTTGTTGATGCCAGCA
AGCAGTCTATCGAAGCCAATGGTCACAGCATTGGTGCCACATTTTATGGTAGGGCCACTCAGGTGGTCAAAGCTGGCGGT
GAGTCACAGGATACCCACTTATTTGATCACAGTTATTCCTGGGTATATGCCGAGGCTAAATTAACCGGTCTGACGGAGGT
TAATGACGCTGCCACTGTCTATCTGAATGCCGCAGCAACTCAAGGTGCTTACGCTGAGAATGTCGTTCTCAACGGCGAAG
ATACAACATTGATGGTGCGCGCGAGTCTGGATAACAATGCCTATGCCACGGTGGATAACCTAATATTGAATGGCGGTGAA
GTGGTTTTCCAGCAGAGCTCTGGCGACCAATATGCTTCATTAAACATCGGCACACTTTCCGGCTCGGGCTCCTTCCTATT
CAATACCTCTATTGCTGAGGGGAAAGGAAACTTCGTGACTATCGCCAATGCCAGTGGGGAACATAAGGTGATAGTTAACG
ACTCTGGCCATGAGATCACCTCACCTGATATGACCACATTGGACTTGATTCACGATCTCAGTGGTGATGCAACATTCACA
CTGGCCTCTATTTCTGGAGCTAACATCATTGAAGTCGATGGCGGCACTTACGTATATAGCTTGAATACCTGGGATAATTC
CGCACGAGCTGGCGGAAATCTGTGGTATTTAGGCTCAGGTTTGAATACAGGCACTGAGCTTGAACCCGAACCTGAAGAGA
AAACAACCCCGTCAACGGATGCGGTGTTGAGTATGGCCTCATCCAACCAGTTTATTTTCGATGGTGAAATGCAAAATCTG
CGTTTTCGTAAAGGGGATTTAAATAATAATAAAGGTGATGGCGCCAGTGTTTGGGGGCGTTATTTAACCAACAATACTCG
GGTCAATGCTGCTCATGATGCCGCTTACCGTTTGCAGCAAGATGGCTTTGAAATTGGTGCTGATAAAGTGCTGGAAATGT
CTTCAGGTCAATTAGTCTTGGGTGGTTTTACCTCTTATAGCAATAACCGAGTGAAACATGCTCGTGGTGGAAACAGTACG
GTTGATAGTTATAGCTTGGGTGCCTACGGCACTTATTTCGATAACAGTGGTTATTATGTCGATGCCGTCGTTAAAGCCAA
CCGTTTTAAAAACTCACTGAATGCCCATATGACCAACGGCGGTTCGGTACAAAGTGATTATAACCAGAATGCAATCGGTG
GCTCACTGGAAGCCGGTTATCACTACAGCCTGTCGAATAATTGGTTCGTAGAGCCTTATGTTCGTACCAGCTATTACACG
GCACAGGATAAAGATATTGCGCTGAATAATGGCATGACAGCGAATATTGATAATAACCGCTCAGCTAAAGGTGAAATAGG
TACACATCTGGGAACGAAGATTGACCTGAATAATGGGGCTATCATCCGCCCTTATGCCAAAGTCGCTATTGAACGAGAGT
TCATCAAATCAAATACCGTGACGATCAATCAGGTTAACGACTTTAATAATGATTTATCAGGACATACCGCGAAGTATGGT
TTAGGCATGGATATCAACCTGATGAAACAGACTTCCGTTTATGCCGAAGCCAATTACCGCAACGGGACTCATGTGGAGTC
ACCTATCATGGCTAATATCGGTTTCCGGATTAATTTCTAA

Upstream 100 bases:

>100_bases
ATTAATTAATCATCATTAATGAGCAATGTAAAATCACAGCGTATCAATATGGAATACGTAAATTTAATGAAATTAAAAAA
TAAATTGGAGTATTGTTACA

Downstream 100 bases:

>100_bases
AGAACATACCAGATGAGTGGTTTCCCGCGATAATGCGGGAGACCATTTTTTTGCTCAATAGATTAAACATGTCTACCCAC
GTTACTTCGAGCTACATCTT

Product: putative autotransporter

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MNTNSKKTYLNIAISFILYASTAMNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVITNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNST
VDSYSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIALNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF

Sequences:

>Translated_759_residues
MNTNSKKTYLNIAISFILYASTAMNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVITNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNST
VDSYSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIALNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
>Mature_759_residues
MNTNSKKTYLNIAISFILYASTAMNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVITNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNST
VDSYSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIALNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=556, Percent_Identity=31.8345323741007, Blast_Score=210, Evalue=3e-55,
Organism=Escherichia coli, GI1787452, Length=483, Percent_Identity=25.4658385093168, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 82292; Mature: 82292

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNSKKTYLNIAISFILYASTAMNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVT
CCCCCCEEEEEEEEEEEEEEHHCCCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEECCCCC
AGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRA
CCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEEEEECCCEEEEEECCCCCCCEEECCC
ENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRY
CCCEECCCEEEEEECCCHHHHCCCCEEEEEEHHHHEEEEEEEEECCCCCCCCCEECCCCC
EDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCC
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVR
CCCCCEEEECCCEEEEEEEEEECCEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEE
ASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVT
EECCCCCEEEEEHEEECCCEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEE
IANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYS
EECCCCCEEEEECCCCCEECCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEE
LNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCC
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVL
EEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
GGFTSYSNNRVKHARGGNSTVDSYSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNG
EEEECCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECHHHHCCCCEEECCC
GSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNR
CCCCCCCCCCCCCCCCCCCEEEECCCCEEECCEEEEEEEECCCCCEEECCCEEEECCCCC
SAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
CCCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
CCCEEEEEEECEEEEEECCCCCCCCCCCEEEECCEEEEC
>Mature Secondary Structure
MNTNSKKTYLNIAISFILYASTAMNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVT
CCCCCCEEEEEEEEEEEEEEHHCCCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEECCCCC
AGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRA
CCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEEEEECCCEEEEEECCCCCCCEEECCC
ENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRY
CCCEECCCEEEEEECCCHHHHCCCCEEEEEEHHHHEEEEEEEEECCCCCCCCCEECCCCC
EDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCC
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVR
CCCCCEEEECCCEEEEEEEEEECCEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEE
ASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVT
EECCCCCEEEEEHEEECCCEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEE
IANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYS
EECCCCCEEEEECCCCCEECCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEE
LNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCC
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVL
EEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
GGFTSYSNNRVKHARGGNSTVDSYSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNG
EEEECCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECHHHHCCCCEEECCC
GSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNR
CCCCCCCCCCCCCCCCCCCEEEECCCCEEECCEEEEEEEECCCCCEEECCCEEEECCCCC
SAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
CCCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
CCCEEEEEEECEEEEEECCCCCCCCCCCEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]