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The map label for this gene is rcsC [H]

Identifier: 218930055

GI number: 218930055

Start: 3360876

End: 3362420

Strand: Direct

Name: rcsC [H]

Synonym: YPO3008

Alternate gene names: 218930055

Gene position: 3360876-3362420 (Clockwise)

Preceding gene: 218930054

Following gene: 218930056

Centisome position: 72.22

GC content: 49.77

Gene sequence:

>1545_bases
ATGAAGCCGTCAAAAAGCCTGTTTCTTTTTACCTCTATCACGTTCTTAATCTGCGCGGCTATCGCCTACTTCGGCTATCG
CAGCCTCACCCATGAAACACTGCTGCGCCATTATCAGAACCAACGTCTGGCACAGAGTCATACCACACAGGTCAGTACAT
TTATTCTGGATCTGCTAAACCAGAATGCCGTGCGTCTGGGTTCGCTTGTTTCTTATATTCAGTTAGATAATGCGTCGCTA
AACGCCCTGATCGCGCAAGAGAGTAGTATTGACGCCCTATTTGTATTGAAGAAAAACCAACTCTTGTACCCCAATACTCA
AGCAGCCTTGACTGAGAAAGAGAAAGCCTGGATACAAGCGATCACCCCTATCATTCAGGACCCGAGCCTGCTCTACAGCC
ACCACTATACCGATGAACAGACCCGGCCAACCTCAGGCTGGTACCTCAGTCGCGAACTCAGCGACCCACTGTTGATATAT
TGGCAGGCGCGGGATAATCAACTGATCGGTTTTAAAGTCCCCTACGTCAAGCTGCTGTCTGATGTGATTAACACCATGAC
ATTTGACTCTGCACCGAACACACTGCAAGTCCTGGATGATGGGCGCTTGCTCTACCAAAGCGGCAGTGAAGAGCTGTTAA
CCCAACAGGTGCCCTTGAATTCCCAACGCCTGCCTTATCCGCTAGGTGCCTGGCAGATAGATTATTACGCCAAGGCGGTA
AACGGCGCGCCCCTTTATCTCTGGGGTGGGCTGCTGTTATTACTGCTGATGGTGACAGTTGGGCTGGTCATGCTATATCT
GTATCGAGAATACAACCGCCAGTTACGGCTTGCTCAACAGCAGGTGAGCTTCGTCGGCCAGGTATCCCACGAACTGAAGA
CGCCACTAACCAATATCACCTTATATGCAGAGATGTTGCAGGAGTTGCAACCAGAGCAGAGCGTTCCTCCCACCGCAGAG
CAGCGCTATCTGGAGGTGATCCTCAATGAAAGCCAGCGGCTCTCGCGCCTGATTCAGAACATCCTCAGTTTTACCAAAGC
GCCGAAACTCCATCTACAAACGGTGGCGCTGCGCCCATTGCTGAACAAAATTTATCACACTTTTATTCCCGCGTTTTCCG
CCAAAAATATGGAGTTGGTGCTGATCATTAATACCGATATTCACCTCACGACCGATGTCGATCGCTTGACGCAGATTATC
AGTAATTTTCTCAGTAATGCCGAAAAATACGCCTCACAAGGAAAACGGGTGGAGTTGATTGGTGAACAGGCTGATGACCG
GGTGTTGATCCACGTAAGGGACTATGGTAACGGCATCGCCGCAAAAGAGTTAAAGGCGATCTTCCAGCCCTTTTATCGAG
TGAAGAGCCATATCACTGAAGGTGTTTCCGGTACCGGTATTGGTTTAACCATCGCCAGCCAATTAGCCGCCAGTTTGCAG
GGCGAAATTTCCGTCACCAGTAATCCGGCGGGTAGCTGTTTTACCCTAAAACTGCCTATGACGATTAAGCAAGATGCGGC
CACAGACAAGGAGCAGTTCACATGA

Upstream 100 bases:

>100_bases
CACCGTTCAAGATCGCGTCATCGGGGTTTGTCAGCAGTCTGAATAAAAGTTCATTTATGCTGAGTCAGTACGCTGGCTCA
GCGTTTACATGGGATATGGC

Downstream 100 bases:

>100_bases
AAATATTAATTGCCGAAGACAATGCCCATATTCGTAATGGCCTTATGGAAGTATTGGCCCATGAAGGGTACCGCCCCATC
GCGGCAGAAAATGGTGTGCA

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKPSKSLFLFTSITFLICAAIAYFGYRSLTHETLLRHYQNQRLAQSHTTQVSTFILDLLNQNAVRLGSLVSYIQLDNASL
NALIAQESSIDALFVLKKNQLLYPNTQAALTEKEKAWIQAITPIIQDPSLLYSHHYTDEQTRPTSGWYLSRELSDPLLIY
WQARDNQLIGFKVPYVKLLSDVINTMTFDSAPNTLQVLDDGRLLYQSGSEELLTQQVPLNSQRLPYPLGAWQIDYYAKAV
NGAPLYLWGGLLLLLLMVTVGLVMLYLYREYNRQLRLAQQQVSFVGQVSHELKTPLTNITLYAEMLQELQPEQSVPPTAE
QRYLEVILNESQRLSRLIQNILSFTKAPKLHLQTVALRPLLNKIYHTFIPAFSAKNMELVLIINTDIHLTTDVDRLTQII
SNFLSNAEKYASQGKRVELIGEQADDRVLIHVRDYGNGIAAKELKAIFQPFYRVKSHITEGVSGTGIGLTIASQLAASLQ
GEISVTSNPAGSCFTLKLPMTIKQDAATDKEQFT

Sequences:

>Translated_514_residues
MKPSKSLFLFTSITFLICAAIAYFGYRSLTHETLLRHYQNQRLAQSHTTQVSTFILDLLNQNAVRLGSLVSYIQLDNASL
NALIAQESSIDALFVLKKNQLLYPNTQAALTEKEKAWIQAITPIIQDPSLLYSHHYTDEQTRPTSGWYLSRELSDPLLIY
WQARDNQLIGFKVPYVKLLSDVINTMTFDSAPNTLQVLDDGRLLYQSGSEELLTQQVPLNSQRLPYPLGAWQIDYYAKAV
NGAPLYLWGGLLLLLLMVTVGLVMLYLYREYNRQLRLAQQQVSFVGQVSHELKTPLTNITLYAEMLQELQPEQSVPPTAE
QRYLEVILNESQRLSRLIQNILSFTKAPKLHLQTVALRPLLNKIYHTFIPAFSAKNMELVLIINTDIHLTTDVDRLTQII
SNFLSNAEKYASQGKRVELIGEQADDRVLIHVRDYGNGIAAKELKAIFQPFYRVKSHITEGVSGTGIGLTIASQLAASLQ
GEISVTSNPAGSCFTLKLPMTIKQDAATDKEQFT
>Mature_514_residues
MKPSKSLFLFTSITFLICAAIAYFGYRSLTHETLLRHYQNQRLAQSHTTQVSTFILDLLNQNAVRLGSLVSYIQLDNASL
NALIAQESSIDALFVLKKNQLLYPNTQAALTEKEKAWIQAITPIIQDPSLLYSHHYTDEQTRPTSGWYLSRELSDPLLIY
WQARDNQLIGFKVPYVKLLSDVINTMTFDSAPNTLQVLDDGRLLYQSGSEELLTQQVPLNSQRLPYPLGAWQIDYYAKAV
NGAPLYLWGGLLLLLLMVTVGLVMLYLYREYNRQLRLAQQQVSFVGQVSHELKTPLTNITLYAEMLQELQPEQSVPPTAE
QRYLEVILNESQRLSRLIQNILSFTKAPKLHLQTVALRPLLNKIYHTFIPAFSAKNMELVLIINTDIHLTTDVDRLTQII
SNFLSNAEKYASQGKRVELIGEQADDRVLIHVRDYGNGIAAKELKAIFQPFYRVKSHITEGVSGTGIGLTIASQLAASLQ
GEISVTSNPAGSCFTLKLPMTIKQDAATDKEQFT

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=35.0649350649351, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=31.7991631799163, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1790436, Length=268, Percent_Identity=29.4776119402985, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=27.9661016949153, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=31.9148936170213, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=30.4347826086957, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=29.7872340425532, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=30.1724137931034, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=27.3809523809524, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=24.1666666666667, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=26.457399103139, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=27.1966527196653, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=25.1162790697674, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=23.8738738738739, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=261, Percent_Identity=25.6704980842912, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1790551, Length=200, Percent_Identity=26, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57971; Mature: 57971

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSKSLFLFTSITFLICAAIAYFGYRSLTHETLLRHYQNQRLAQSHTTQVSTFILDLLN
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNAVRLGSLVSYIQLDNASLNALIAQESSIDALFVLKKNQLLYPNTQAALTEKEKAWIQA
CCHHHHHHHHHHHEECCCCCEEEEECCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHHH
ITPIIQDPSLLYSHHYTDEQTRPTSGWYLSRELSDPLLIYWQARDNQLIGFKVPYVKLLS
HHHHHCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECHHHHHHH
DVINTMTFDSAPNTLQVLDDGRLLYQSGSEELLTQQVPLNSQRLPYPLGAWQIDYYAKAV
HHHHHHCCCCCCCEEEEECCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHC
NGAPLYLWGGLLLLLLMVTVGLVMLYLYREYNRQLRLAQQQVSFVGQVSHELKTPLTNIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LYAEMLQELQPEQSVPPTAEQRYLEVILNESQRLSRLIQNILSFTKAPKLHLQTVALRPL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LNKIYHTFIPAFSAKNMELVLIINTDIHLTTDVDRLTQIISNFLSNAEKYASQGKRVELI
HHHHHHHHHCCCCCCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
GEQADDRVLIHVRDYGNGIAAKELKAIFQPFYRVKSHITEGVSGTGIGLTIASQLAASLQ
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GEISVTSNPAGSCFTLKLPMTIKQDAATDKEQFT
CCEEEECCCCCCEEEEEECCEECCCCCCCHHCCC
>Mature Secondary Structure
MKPSKSLFLFTSITFLICAAIAYFGYRSLTHETLLRHYQNQRLAQSHTTQVSTFILDLLN
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNAVRLGSLVSYIQLDNASLNALIAQESSIDALFVLKKNQLLYPNTQAALTEKEKAWIQA
CCHHHHHHHHHHHEECCCCCEEEEECCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHHH
ITPIIQDPSLLYSHHYTDEQTRPTSGWYLSRELSDPLLIYWQARDNQLIGFKVPYVKLLS
HHHHHCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECHHHHHHH
DVINTMTFDSAPNTLQVLDDGRLLYQSGSEELLTQQVPLNSQRLPYPLGAWQIDYYAKAV
HHHHHHCCCCCCCEEEEECCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHC
NGAPLYLWGGLLLLLLMVTVGLVMLYLYREYNRQLRLAQQQVSFVGQVSHELKTPLTNIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LYAEMLQELQPEQSVPPTAEQRYLEVILNESQRLSRLIQNILSFTKAPKLHLQTVALRPL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LNKIYHTFIPAFSAKNMELVLIINTDIHLTTDVDRLTQIISNFLSNAEKYASQGKRVELI
HHHHHHHHHCCCCCCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
GEQADDRVLIHVRDYGNGIAAKELKAIFQPFYRVKSHITEGVSGTGIGLTIASQLAASLQ
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GEISVTSNPAGSCFTLKLPMTIKQDAATDKEQFT
CCEEEECCCCCCEEEEEECCEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]