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The map label for this gene is guaA [H]

Identifier: 218929930

GI number: 218929930

Start: 3203461

End: 3205038

Strand: Reverse

Name: guaA [H]

Synonym: YPO2870

Alternate gene names: 218929930

Gene position: 3205038-3203461 (Counterclockwise)

Preceding gene: 218929931

Following gene: 218929929

Centisome position: 68.87

GC content: 49.43

Gene sequence:

>1578_bases
ATGACAAAAAATATCCATAAGCATCGCATCCTTATTCTTGATTTCGGCTCGCAGTACACCCAATTATTGGCGCGTCGTGT
GCGTGAGATTGGTGTCTATTGTGAACTATGGGCATGGGATGTCACCGAAGCCCAAATCCGTGAATTTAATCCAAGTGGTA
TCATCCTCTCTGGTAGCCCTGAAAGTACGATAGAAAACGGTAGCCCGCGCGCACCAGACTATGTGTTTACGGCTGGTGTA
CCGGTGTTGGGTGTGTGCTATGGCATGCAGACCATGGCGATACAATTGGGCGGTAAAGTTGAGAGTTCAAATCAGCGTGA
ATTTGGTTATGCGCAAGTTGAAATTAAAGCTGACAGCGCGCTGATCCGTGATATCAAAGATGCCATCAATCCGGCAGGCG
AAGCCGTATTGGATGTTTGGATGAGTCACGGTGACAAAGTTGCGGAGATCCCTGCTGATTTTGTCACGGTTGCCAGCACG
GATACCTGTCCGTTTGCCATTATGGCTAACGAAGAAAAACGTTTTTATGGTGTCCAGTTCCATCCTGAAGTGACACACAC
CAAGCAAGGCCTGCGTTTGTTGGAGCGTTTCGTGCTGGGTATCTGTGGCTGCGAAGCGCTATGGACATCTGCCACCATTA
TCGAAGATGCAATTGTCCGTTTGCGTGAGCAAATCGGCGACGATCATGTGATCTTGGGGTTAAGTGGCGGTGTCGACTCT
TCAGTGACGGCCATGTTGTTGCACCGCGCTATCGGTAAACGCCTGACCTGTGTATTCGTGGATAACGGCCTATTACGCTT
AAACGAAGCAGATCAGGTCTTGGAAATGTTTGGCGATAAATTTGGCCTGAATATTGTCCATGTGGCGGCAGAGGATCGCT
TCCTTTCGGCACTGACGGGAGTGGACGAACCAGAAGCGAAACGTAAAATCATTGGCCGTGTCTTTGTCGAACTCTTCGAC
GAAGAAGCCTGTAAACAAGAGCAGGTGAAATGGTTGGCACAGGGTACGATTTACCCTGATGTGATCGAATCGGCTGCATC
AGCTACCGGTAAAGCGCATGTGATTAAATCTCACCACAATGTGGGCGGTTTGCCAAAAGAGATGAAGCTGGGCCTGGTTG
AGCCGCTGAAAGAGCTGTTTAAAGATGAAGTGCGCAAGATTGGTCTGGAGCTTGGCTTGCCATACGACATGCTGTACCGC
CATCCTTTCCCAGGGCCGGGCTTAGGTGTGCGCGTATTGGGCGAAGTGAAGAAAGAGTATTGCGATTTGCTGCGCCGTGC
TGACGCTATCTTTATTGAAGAGCTGCACAAAGCTGATTTGTACAATAAAGTTAGCCAGGCTTTCACTGTCTTCCTGCCAG
TACGTTCAGTCGGTGTGATGGGTGATGGCCGTAAATATGATTGGGTTGTCTCTCTGCGTGCGGTAGAGACGGTTGATTTC
ATGACTGCACATTGGGCACATCTGCCATACGACTTCCTTGGCCGCGTTTCAAACCGCATCATTAATGAAGTCAATGGTAT
CTCGCGCGTAGTTTATGATATCAGCGGCAAGCCACCTGCAACGATTGAGTGGGAATGA

Upstream 100 bases:

>100_bases
GTTGCAGTAAGGCAGCAAATAAACGGGTCTCGAAGTCAGTGATTCGTGCTCGCACCACGGTAATGTCAAGTAAGAAGGGT
ATTTTTGGAATACGCCACAC

Downstream 100 bases:

>100_bases
TTTTATCGTTTTTAACCATGGTTGATAACGATTGAAAATAGCAAAAACCGCCTTGAATATTAGGCGGTTTGAGGTTATTG
ACAACGCTATTTTAGCTTGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGV
PVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVAST
DTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDS
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFD
EEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGV
PVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVAST
DTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDS
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFD
EEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
>Mature_524_residues
TKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGVP
VLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTD
TCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDSS
VTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFDE
EACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDFM
TAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=573, Percent_Identity=35.9511343804538, Blast_Score=290, Evalue=3e-78,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=87.6190476190476, Blast_Score=966, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=34.9480968858132, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=34.9480968858132, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=34.9480968858132, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=48.1835564053537, Blast_Score=512, Evalue=1e-146,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.1785714285714, Blast_Score=279, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58423; Mature: 58292

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHCCCCCCEEEECCC
ESTIENGSPRAPDYVFTAGVPVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCHH
LIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTDTCPFAIMANEEKRFYGVQF
HHHHHHHHHCHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCEEEEECCCCEEEEEEE
HPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEEECCHHHHHHHCC
VDEPEAKRKIIGRVFVELFDEEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHCCCCCCEEEECCC
ESTIENGSPRAPDYVFTAGVPVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCHH
LIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTDTCPFAIMANEEKRFYGVQF
HHHHHHHHHCHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCEEEEECCCCEEEEEEE
HPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEEECCHHHHHHHCC
VDEPEAKRKIIGRVFVELFDEEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA