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The map label for this gene is upp [H]

Identifier: 218929892

GI number: 218929892

Start: 3153841

End: 3154467

Strand: Reverse

Name: upp [H]

Synonym: YPO2827

Alternate gene names: 218929892

Gene position: 3154467-3153841 (Counterclockwise)

Preceding gene: 218929896

Following gene: 218929891

Centisome position: 67.78

GC content: 48.01

Gene sequence:

>627_bases
ATGAAGATCGTTGAGGTGAAGCACCCGCTAGTAAAACATAAACTTGGTTTGATGCGTGAGAATGATATCAGCACGAAACG
TTTTCGCGAATTGGCTTCCGAGGTGGGGAGTTTGCTGACTTACGTAGCAACCGCTGATCTGGAAACTGAAACAGTGACCA
TCGAAGGTTGGAATGGGCCGGTTGAAATAGAACAGATTAAAGGTAAGAAAATTACAGTGGTGCCAATCCTGCGTGCGGGT
CTGGGGATGATGGAAGGGGTGTTGGAAAATGTGCCCAGTGCGCGTATCAGTGTGGTAGGTGTGTATCGCGATGAAGAGAC
GCTGAAACCGGTACCGTATTTCCAGAAGTTGGTTTCCAATATCAACGAACGCATGGCGTTAGTGGTTGACCCAATGTTGG
CAACCGGTGGTTCTATGATTGCTACTATCGATTTGCTCAAGAAAGCAGGCTGCCAGAGCATTAAGGTATTGGTGTTAGTT
GCTGCACCAGAAGGTATCAAGGCGCTGGAAGAAGCGCATCCGGATGTTGAATTGTACACCGCCTCCATCGATCAGGGCCT
GAACGAACACGGTTATATTATCCCTGGGTTGGGTGATGCCGGGGATAAGATTTTCGGAACTAAATAA

Upstream 100 bases:

>100_bases
TATTGATCTGAATCAGGCTATTCATTATGGCGTTCAAAAAGAAAGGCGGTATAATCTCGCGATTTTTTTGGCCGTCGACC
GCCTAACCAGGAGAAAAATA

Downstream 100 bases:

>100_bases
CGATGATAGCCGACGTGAAAGTCGGCTTTTTTGTGCCCAGAAAACCCCCAGCTAGGCTGGGGGTTCAGTAAAGCTTTCAG
CTTTGGGTCAGTTATAAAAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGPVEIEQIKGKKITVVPILRAG
LGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSNINERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLV
AAPEGIKALEEAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGPVEIEQIKGKKITVVPILRAG
LGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSNINERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLV
AAPEGIKALEEAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
>Mature_208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGPVEIEQIKGKKITVVPILRAG
LGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSNINERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLV
AAPEGIKALEEAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=26.2376237623762, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.2376237623762, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=93.2692307692308, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=158, Percent_Identity=39.873417721519, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=26.1083743842365, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=26.1083743842365, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=26.1083743842365, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=26.1083743842365, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22575; Mature: 22575

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGP
CEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VEIEQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSN
EEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
INERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLVAAPEGIKALEEAHPDVELYT
HHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCEEEEE
ASIDQGLNEHGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGP
CEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VEIEQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSN
EEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
INERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLVAAPEGIKALEEAHPDVELYT
HHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCEEEEE
ASIDQGLNEHGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA