Click here to switch to the map view.

The map label for this gene is fadI [H]

Identifier: 218929818

GI number: 218929818

Start: 3076747

End: 3078057

Strand: Direct

Name: fadI [H]

Synonym: YPO2746

Alternate gene names: 218929818

Gene position: 3076747-3078057 (Clockwise)

Preceding gene: 218929817

Following gene: 218929819

Centisome position: 66.11

GC content: 53.17

Gene sequence:

>1311_bases
ATGAGTAAGCCATTACCGTTAGTGACGCGTCAGGGCGATCGCATTGTAATAGTTAACGGCCTGCGGACCCCTTTCGCCAA
GCAGGCAACTGCTTACCATGGCGTACCCGCTGTAGATTTAGGCAAAATAGTGGTCAGTGAATTGCTGGCCAGAAGTGGCA
TTTCTTCTGAGTTGATTGATCAACTGGTTTTTGGCCAAGTAGTGCAAATGCCTGAAGCACCTAATATTGCCCGCGAAATC
GTTTTGGGTACTGGCATGAGCGTTCATACCGATGCTTACAGCGTTTCCCGCGCCTGTGCGACCAGTTTTCAGGCGGTGGC
CAATGTCGCGGAAAGTATTATTGCTGGCTCCGTTGATATCGCGATAGCCGGCGGGGCAGATTCTTCATCCGTGCTGCCCA
TCGGCGTCAGTAAAGCCCTGGCCCGCACACTGGTTGACGCCAACAAGGCCCGCAGTTTATCCCAGAAGTTGAAATTGTTT
AGCCGACTTAGATTACGTGATCTGTTGCCAGTTGCACCTGCGGTGGCAGAGTATTCAACCGGCCTGCGCATGGGGGATAC
TGCCGAGCAGATGGCAAAAACCTATGGCATCAGCCGTGAGGATCAGGATGCTTTAGCGCTGCGATCCCACCAATTGGCCG
CTGAAGCCTGGCAACAGGGGTGGCTGCACGATGAGGTGATGACGGCTTATATTCCGCCTTATCGAGAGGCCATTATTGAA
GATAACAATATCCGCAAAGATTCCACATTGGCGCAATATGCCAAATTACGTCCGGCGTTTGATCGTCAGCACGGTAGTGT
GACGGCGGCGAACAGTACTCCGTTGACGGACGGGGCGGCGGCAGTACTCATGATGAGCGAATCAAAAGCCAAAGCTCTGG
GGTTGCCGCCTTTGGGCTACCTGCGCAGTTTTGCCTTCTCTGCCATTGATGTTTGGCAGGATATGCTGTTAGGGCCATCC
TATGCCACGCCATTAGCGTTAGACCGGGCGGGTATTACACTGGCGGATTTGACACTTATCGATATGCATGAAGCCTTCGC
CGCACAAACACTGGCTAACCTGAAAATGTTTGCCAGTGATACTTTTGCTCGCGAAAAACTGGGGCGTAGCCAAGCCATCG
GAGAGGTGGATATGAGTAAATTCAACGTATTGGGGGGTTCCATTGCATATGGCCACCCATTTGCCGCTACTGGCGCTCGG
ATGATAACTCAAACGCTGAATGAGTTGCGTCGCCGTGGCGGGGGATTGGGCTTAACCACCGCCTGTGCTGCTGGTGGGTT
AGGTGCTGCGATGATTCTGGAGGTGGAGTGA

Upstream 100 bases:

>100_bases
TGCCAAATGTAAACGTTTGGTTAACAATGTTCGGATCAGGTCAGACCTGTTATTTGTTATCTTTTAATCGCAGCCACTCT
ACTTATTATCAGGAGCGCTT

Downstream 100 bases:

>100_bases
TGAGCAAGGAAAATATCGTTACCCGTGAAAATACAGCTGTCAGTGAAAATGCAGTCAGTGAACCTACAGTGAATAATGAT
GTGGGCGCATCGGCCACGAA

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSKPLPLVTRQGDRIVIVNGLRTPFAKQATAYHGVPAVDLGKIVVSELLARSGISSELIDQLVFGQVVQMPEAPNIAREI
VLGTGMSVHTDAYSVSRACATSFQAVANVAESIIAGSVDIAIAGGADSSSVLPIGVSKALARTLVDANKARSLSQKLKLF
SRLRLRDLLPVAPAVAEYSTGLRMGDTAEQMAKTYGISREDQDALALRSHQLAAEAWQQGWLHDEVMTAYIPPYREAIIE
DNNIRKDSTLAQYAKLRPAFDRQHGSVTAANSTPLTDGAAAVLMMSESKAKALGLPPLGYLRSFAFSAIDVWQDMLLGPS
YATPLALDRAGITLADLTLIDMHEAFAAQTLANLKMFASDTFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGAR
MITQTLNELRRRGGGLGLTTACAAGGLGAAMILEVE

Sequences:

>Translated_436_residues
MSKPLPLVTRQGDRIVIVNGLRTPFAKQATAYHGVPAVDLGKIVVSELLARSGISSELIDQLVFGQVVQMPEAPNIAREI
VLGTGMSVHTDAYSVSRACATSFQAVANVAESIIAGSVDIAIAGGADSSSVLPIGVSKALARTLVDANKARSLSQKLKLF
SRLRLRDLLPVAPAVAEYSTGLRMGDTAEQMAKTYGISREDQDALALRSHQLAAEAWQQGWLHDEVMTAYIPPYREAIIE
DNNIRKDSTLAQYAKLRPAFDRQHGSVTAANSTPLTDGAAAVLMMSESKAKALGLPPLGYLRSFAFSAIDVWQDMLLGPS
YATPLALDRAGITLADLTLIDMHEAFAAQTLANLKMFASDTFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGAR
MITQTLNELRRRGGGLGLTTACAAGGLGAAMILEVE
>Mature_435_residues
SKPLPLVTRQGDRIVIVNGLRTPFAKQATAYHGVPAVDLGKIVVSELLARSGISSELIDQLVFGQVVQMPEAPNIAREIV
LGTGMSVHTDAYSVSRACATSFQAVANVAESIIAGSVDIAIAGGADSSSVLPIGVSKALARTLVDANKARSLSQKLKLFS
RLRLRDLLPVAPAVAEYSTGLRMGDTAEQMAKTYGISREDQDALALRSHQLAAEAWQQGWLHDEVMTAYIPPYREAIIED
NNIRKDSTLAQYAKLRPAFDRQHGSVTAANSTPLTDGAAAVLMMSESKAKALGLPPLGYLRSFAFSAIDVWQDMLLGPSY
ATPLALDRAGITLADLTLIDMHEAFAAQTLANLKMFASDTFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGARM
ITQTLNELRRRGGGLGLTTACAAGGLGAAMILEVE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=43.8095238095238, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI4501853, Length=430, Percent_Identity=33.0232558139535, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4557237, Length=423, Percent_Identity=28.3687943262411, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI167614485, Length=423, Percent_Identity=31.4420803782506, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI148539872, Length=428, Percent_Identity=31.0747663551402, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1788683, Length=436, Percent_Identity=80.5045871559633, Blast_Score=712, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=422, Percent_Identity=35.3080568720379, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1788554, Length=426, Percent_Identity=35.9154929577465, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787663, Length=426, Percent_Identity=34.5070422535211, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI48994986, Length=434, Percent_Identity=34.331797235023, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=39.9049881235154, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133906874, Length=426, Percent_Identity=30.9859154929577, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=423, Percent_Identity=28.8416075650118, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25147385, Length=419, Percent_Identity=27.4463007159904, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=427, Percent_Identity=23.4192037470726, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325229, Length=437, Percent_Identity=30.6636155606407, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322031, Length=378, Percent_Identity=30.1587301587302, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=42.8904428904429, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24655093, Length=422, Percent_Identity=30.8056872037915, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24640423, Length=425, Percent_Identity=27.5294117647059, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17648125, Length=429, Percent_Identity=30.0699300699301, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46312; Mature: 46181

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLPLVTRQGDRIVIVNGLRTPFAKQATAYHGVPAVDLGKIVVSELLARSGISSELID
CCCCCCCEECCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESIIAGSVDI
HHHHHHHHCCCCCCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIAGGADSSSVLPIGVSKALARTLVDANKARSLSQKLKLFSRLRLRDLLPVAPAVAEYST
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRMGDTAEQMAKTYGISREDQDALALRSHQLAAEAWQQGWLHDEVMTAYIPPYREAIIE
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHC
DNNIRKDSTLAQYAKLRPAFDRQHGSVTAANSTPLTDGAAAVLMMSESKAKALGLPPLGY
CCCCCCHHHHHHHHHHCCHHHCCCCCEEECCCCCCCCCCEEEEEEECCCHHHCCCCCHHH
LRSFAFSAIDVWQDMLLGPSYATPLALDRAGITLADLTLIDMHEAFAAQTLANLKMFASD
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
TFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGARMITQTLNELRRRGGGLGLTT
HHHHHHHCHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMILEVE
HHHCCCCCEEEEEEEC
>Mature Secondary Structure 
SKPLPLVTRQGDRIVIVNGLRTPFAKQATAYHGVPAVDLGKIVVSELLARSGISSELID
CCCCCCEECCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESIIAGSVDI
HHHHHHHHCCCCCCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIAGGADSSSVLPIGVSKALARTLVDANKARSLSQKLKLFSRLRLRDLLPVAPAVAEYST
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRMGDTAEQMAKTYGISREDQDALALRSHQLAAEAWQQGWLHDEVMTAYIPPYREAIIE
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHC
DNNIRKDSTLAQYAKLRPAFDRQHGSVTAANSTPLTDGAAAVLMMSESKAKALGLPPLGY
CCCCCCHHHHHHHHHHCCHHHCCCCCEEECCCCCCCCCCEEEEEEECCCHHHCCCCCHHH
LRSFAFSAIDVWQDMLLGPSYATPLALDRAGITLADLTLIDMHEAFAAQTLANLKMFASD
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
TFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGARMITQTLNELRRRGGGLGLTT
HHHHHHHCHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMILEVE
HHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA