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The map label for this gene is ccmG

Identifier: 218929812

GI number: 218929812

Start: 3071277

End: 3071843

Strand: Direct

Name: ccmG

Synonym: YPO2740

Alternate gene names: 218929812

Gene position: 3071277-3071843 (Clockwise)

Preceding gene: 218929811

Following gene: 218929813

Centisome position: 66.0

GC content: 49.74

Gene sequence:

>567_bases
ATGAAACCTCAATCCTCATTCAATAAGCTGATGTTTATTCCGCTGGTCCTTTTCTTACTGCTGGTCGTGGCATTCCTGAT
ACAACTGACCCGTAATGCCAACGGCGAAGATCCAACGATGTTGGAGTCGGCGCTGATCGGCAAGCCCGTACCGGCATTCA
AACTGGAATCCCTCGAACAGCCGGGTAAAACCTTTGATCAGGCGGTATTACGTGATGGTAAACCGATACTGCTGAATGTT
TGGGCAACATGGTGCCCAACTTGCCGTGCCGAGCATGAATACCTGAATAAATTGGCGGCTCAAGGTATCCGTGTGGTGGG
CCTGAATTATAAAGATGACCGTAGCAAAGCCGTGCAGTGGCTGAATTCGCTGGGTAACCCTTATTTTCTCAGTTTGTATG
ATGGTGATGGAATGTTGGGCCTGGATTTGGGGGTATACGGCGCACCAGAAACGTTCCTTATCGATGGTCAAGGGGTTATC
CGTTACCGCCATGCTGGTGATCTTAATGATCGGGTCTGGCAGCAGGAAATCTTACCGCTGTATAAAAAGTACCAGGGGGG
CGCATGA

Upstream 100 bases:

>100_bases
GCGGGATCTTTATGGCCGTCGGCGGCATCTTCTGTATGCTCGATCCGCGCTATCGGATGAGTAAAAAGCTAAAACGCGGT
GCGATACCGGAGGCAGAGTC

Downstream 100 bases:

>100_bases
GGTTACTCAGTCTGCTACTGGGTCTGATATTGAGCTGGGGAGTATTGGCGACCATCGATACTTATCGCTTCAGTTCGGTA
GAACAAGAGCAGCAATACCG

Product: thiol:disulfide interchange protein DsbE

Products: NA

Alternate protein names: Cytochrome c biogenesis protein CcmG

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKPQSSFNKLMFIPLVLFLLLVVAFLIQLTRNANGEDPTMLESALIGKPVPAFKLESLEQPGKTFDQAVLRDGKPILLNV
WATWCPTCRAEHEYLNKLAAQGIRVVGLNYKDDRSKAVQWLNSLGNPYFLSLYDGDGMLGLDLGVYGAPETFLIDGQGVI
RYRHAGDLNDRVWQQEILPLYKKYQGGA

Sequences:

>Translated_188_residues
MKPQSSFNKLMFIPLVLFLLLVVAFLIQLTRNANGEDPTMLESALIGKPVPAFKLESLEQPGKTFDQAVLRDGKPILLNV
WATWCPTCRAEHEYLNKLAAQGIRVVGLNYKDDRSKAVQWLNSLGNPYFLSLYDGDGMLGLDLGVYGAPETFLIDGQGVI
RYRHAGDLNDRVWQQEILPLYKKYQGGA
>Mature_188_residues
MKPQSSFNKLMFIPLVLFLLLVVAFLIQLTRNANGEDPTMLESALIGKPVPAFKLESLEQPGKTFDQAVLRDGKPILLNV
WATWCPTCRAEHEYLNKLAAQGIRVVGLNYKDDRSKAVQWLNSLGNPYFLSLYDGDGMLGLDLGVYGAPETFLIDGQGVI
RYRHAGDLNDRVWQQEILPLYKKYQGGA

Specific function: Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1788523, Length=180, Percent_Identity=72.2222222222222, Blast_Score=282, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DSBE_YERPE (Q8ZD52)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0334
- RefSeq:   NP_668891.1
- RefSeq:   NP_993752.1
- RefSeq:   YP_002347687.1
- ProteinModelPortal:   Q8ZD52
- SMR:   Q8ZD52
- GeneID:   1146520
- GeneID:   1175571
- GeneID:   2763374
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2740
- KEGG:   ypk:y1573
- KEGG:   ypm:YP_2424
- HOGENOM:   HBG493509
- OMA:   KWLAEFH
- ProtClustDB:   CLSK889283
- BioCyc:   YPES187410:Y1573-MONOMER
- BioCyc:   YPES214092:YPO2740-MONOMER
- InterPro:   IPR004799
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- TIGRFAMs:   TIGR00385

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 21073; Mature: 21073

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1884a46c)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPQSSFNKLMFIPLVLFLLLVVAFLIQLTRNANGEDPTMLESALIGKPVPAFKLESLEQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCC
PGKTFDQAVLRDGKPILLNVWATWCPTCRAEHEYLNKLAAQGIRVVGLNYKDDRSKAVQW
CCHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
LNSLGNPYFLSLYDGDGMLGLDLGVYGAPETFLIDGQGVIRYRHAGDLNDRVWQQEILPL
HHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHH
YKKYQGGA
HHHHCCCH
>Mature Secondary Structure
MKPQSSFNKLMFIPLVLFLLLVVAFLIQLTRNANGEDPTMLESALIGKPVPAFKLESLEQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCC
PGKTFDQAVLRDGKPILLNVWATWCPTCRAEHEYLNKLAAQGIRVVGLNYKDDRSKAVQW
CCHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
LNSLGNPYFLSLYDGDGMLGLDLGVYGAPETFLIDGQGVIRYRHAGDLNDRVWQQEILPL
HHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHH
YKKYQGGA
HHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430