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The map label for this gene is lipB [H]

Identifier: 218929680

GI number: 218929680

Start: 2920232

End: 2920921

Strand: Reverse

Name: lipB [H]

Synonym: YPO2599

Alternate gene names: 218929680

Gene position: 2920921-2920232 (Counterclockwise)

Preceding gene: 218929681

Following gene: 218929679

Centisome position: 62.77

GC content: 48.84

Gene sequence:

>690_bases
TTGCAACAACACAAGATCATTTTACGTCAGCTAGGGTTACAACCCTATGCACCCGTATCCCAAGCCATGCATAACTTTAC
TGAGTTTCGCACTGATACCACACCAGACGAAATCTGGTTGGTTGAGCATCAGCACGTCTTTACTCAGGGTCAGGCTGGAA
AAGCTGAACATGTCCTGATGCCAGGTGATATTCCGGTTATTCAAAGTGATAGGGGGGGTCAGGTCACCTACCATGGCCCC
GGCCAGCAAGTGATGTATGTCATGGTTGATCTCAAACGTGCCAAAATCGGTGTACGCCAGCTAGTCACCGCCATTGAGAA
TACGGTGATAGAGACTCTCGCCCATTTCAATATTGATTCACATGCTCGCCCAGATGCCCCCGGTGTCTATGTTGAACAAC
AGAAAATATGCTCACTGGGGCTACGCATCCGCCGAGGCTGTTCGTTTCACGGTTTAGCATTGAACATTGCGATGGATCTG
GAACCGTTCCAGCGCATTAATCCGTGCGGCTACGCGGGTATGCAGATGACACAAGTCAGTGCATTACAACCAGGGGTTAC
CGTTGCGGATGTGCAGCCTGTATTGGTTCGCGAATTTACCCGCCAATTAGGTTATCCGACGGCAAAATTGCAGCCGTGGT
CATTATCAGACTATTTATTATCAAGCCATTCATCATCAAGCGTGTTGTAA

Upstream 100 bases:

>100_bases
TTAGCCATCAAATTATAGCGTTGAACTGTCAAAATAGTGGCCCCACTCAGCGGGGCTGGTATACTGGCGCTACCATTTCT
GTAACCAGATGATGCCTCGC

Downstream 100 bases:

>100_bases
ATGACTCATATGCCCGATGTAACTGAAACCGTGAACGCCACCATCGCGCCAAAAGTGAATGGCTGAACGAAACAGAGTAA
AGATGATATAATTTTTAAAC

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTYHGP
GQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDL
EPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL

Sequences:

>Translated_229_residues
MQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTYHGP
GQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDL
EPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
>Mature_229_residues
MQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTYHGP
GQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDL
EPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=134, Percent_Identity=38.0597014925373, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI87081767, Length=206, Percent_Identity=68.9320388349515, Blast_Score=308, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323268, Length=157, Percent_Identity=35.6687898089172, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355483, Length=194, Percent_Identity=30.9278350515464, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 25498; Mature: 25498

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLM
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCEEEE
PGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDS
CCCCCEEECCCCCEEEEECCCCEEEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMTQVS
CCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHHHHH
ALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
HCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLM
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCEEEE
PGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTAIENTVIETLAHFNIDS
CCCCCEEECCCCCEEEEECCCCEEEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMTQVS
CCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHHHHH
ALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
HCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA