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The map label for this gene is nuoE [H]

Identifier: 218929638

GI number: 218929638

Start: 2866561

End: 2867079

Strand: Reverse

Name: nuoE [H]

Synonym: YPO2552

Alternate gene names: 218929638

Gene position: 2867079-2866561 (Counterclockwise)

Preceding gene: 218929639

Following gene: 218929637

Centisome position: 61.61

GC content: 55.11

Gene sequence:

>519_bases
GTGGTGAATCTGGCAGTCAATGCGGCTGAACCAGCGGCCATGCCAGACGCCTTCGAATTGAGTGCCGAAGAACGTGATGC
TATCGAGCATGAGAAACACCATTACGAAGATGCCCGTGCTGCGTCGATTGAAGCACTGAAAATTGTGCAGAAGCAACGTG
GCTGGGTGCCGGATGGTGCGATCCACGCGATTGCTGATGTGCTGGGTATCCCGGCCAGTGATGTTGAGGGGGTCGCCACC
TTCTACAGCCAAATCTTCCGCCAACCGGTAGGGCGTCATGTGATCCGCTACTGTGACAGCGTGGTGTGTCATATCACCGG
CTATCAGGGGATTCAGGCGGCACTGGAGAAAAAACTCAGTATCAAGCCAGGCCAAACGACCTTCGATGGCCGTTTCACCC
TGCTGCCAACCTGTTGTCTGGGTAACTGCGACCGTGGGCCGACGATGATGATCGATGACGACACCCACAGCTACCTGAAG
CCTGAAGAGATCGAGAAGTTACTGGAGCAATATCCATGA

Upstream 100 bases:

>100_bases
TGATCGTCTATCTGGGCAGTATCGATTTTGTAATGTCTGATGTGGACCGCTAATTATGAGTGATCAAAAAGAGACTCAGG
CTCATAACGGAAGCCTTGAT

Downstream 100 bases:

>100_bases
CCATCAATTCAGGAACGACCAAGGAAATTATCCGGACGCCAGAAATGCACCCGCTGACCTGGCGTTTGCGCGATGACAAA
CAGCCCGTGTGGCTGGATGA

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E; NUO5 [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MVNLAVNAAEPAAMPDAFELSAEERDAIEHEKHHYEDARAASIEALKIVQKQRGWVPDGAIHAIADVLGIPASDVEGVAT
FYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKKLSIKPGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDDTHSYLK
PEEIEKLLEQYP

Sequences:

>Translated_172_residues
MVNLAVNAAEPAAMPDAFELSAEERDAIEHEKHHYEDARAASIEALKIVQKQRGWVPDGAIHAIADVLGIPASDVEGVAT
FYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKKLSIKPGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDDTHSYLK
PEEIEKLLEQYP
>Mature_172_residues
MVNLAVNAAEPAAMPDAFELSAEERDAIEHEKHHYEDARAASIEALKIVQKQRGWVPDGAIHAIADVLGIPASDVEGVAT
FYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKKLSIKPGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDDTHSYLK
PEEIEKLLEQYP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=170, Percent_Identity=35.2941176470588, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788621, Length=156, Percent_Identity=89.1025641025641, Blast_Score=296, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17561328, Length=154, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859877, Length=170, Percent_Identity=34.1176470588235, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355353, Length=153, Percent_Identity=30.718954248366, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19038; Mature: 19038

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLAVNAAEPAAMPDAFELSAEERDAIEHEKHHYEDARAASIEALKIVQKQRGWVPDGA
CCEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IHAIADVLGIPASDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKKLS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
IKPGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDDTHSYLKPEEIEKLLEQYP
CCCCCCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVNLAVNAAEPAAMPDAFELSAEERDAIEHEKHHYEDARAASIEALKIVQKQRGWVPDGA
CCEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IHAIADVLGIPASDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKKLS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
IKPGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDDTHSYLKPEEIEKLLEQYP
CCCCCCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]