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The map label for this gene is edd [H]

Identifier: 218929619

GI number: 218929619

Start: 2842212

End: 2844089

Strand: Reverse

Name: edd [H]

Synonym: YPO2533

Alternate gene names: 218929619

Gene position: 2844089-2842212 (Counterclockwise)

Preceding gene: 218929620

Following gene: 218929618

Centisome position: 61.11

GC content: 53.25

Gene sequence:

>1878_bases
ATGGAGATGAACCCCATTATCACCCGTGTCACGCAGCGTATCATTGCGCGCTCAGCGGCCACACGCACGGCATATCTGCA
ACGTATCAGTGCAGCAAAAGAGCATACCGTTCACCGTTCACAACTGGCTTGCGGTAATCTGGCGCACGGCTTTGCGGCTT
GTCAGCCAGAGGATAAAGCGGCCCTAAAAAATAGGGTGCGTAGCGATATCGCCATCATTACGTCCTATAACGATATGCTG
TCTGCTCATCAACCTTATGAACATTACCCACAACAACTGAAAGACGCATTGCATGAGGTTGGGGCCATTGGGCAGGTTGC
CGGTGGGGTTCCTGCCATGTGTGATGGGGTGACGCAAGGGCAGGATGGGATGGAGTTGTCGCTAATGAGCCGCGATGTGA
TTGCTATGTCAGCGGCTATTGGCCTGTCACACAATATGTTTGATGGTGCTCTCTACCTCGGTGTGTGCGATAAAATCGTT
CCCGGTTTGTTAATGGCAGCGCTGTCATTTGGCCATTTACCGGCTATTTTTGTCCCCGCCGGGCCTATGGCCAGCGGTTT
GCCTAACAAAGAGAAAGTCCGGATCCGCCAACTTTACGCCGAGGGGAAAGTGGATAGGCAAGCCTTGTTGGAGGCTGAAG
CCGCTTCGTATCACAGTGCCGGGACCTGTACTTTTTACGGTACTGCCAATTCTAATCAGATGGTGATGGAAGTGATGGGG
CTGCATTTGCCGGGAGCCTCTTTTATCCAACCGAATACACCACTGCGTGATGCGCTGACTGCAGCGGCGGCACGTCAAAT
CACCCGTCTGACCGAAACCGGCATTAATTGTATTGATGGCAATCATATTGATGTTAACCATATCAACAGTAGCCATATCA
ACAGCAGCTATTTGCCTGTTGGCCAATTGGTGGATGAAAAAGTGGTCGTCAATGGGATTGTCGCGCTGCTGGCAACCGGC
GGTTCGACTAATCACACCTTACATTTGGTCGCGATGGCGCGGGCGGCGGGCATCATCATTAATTGGGATGATTTCTCTGA
ACTGTCGGAAGCGGTGCCGCAGCTATGCCGTATTTACCCTAATGGCCCAGCGGACATCAACTATTTTCAGGCATCGGGTG
GTGTGGCACTGCTGGTTAATATGCTATTGCAAGGCGGTTTACTGCACGAAGAGGTGCATACCGTCGCTGGATTTGGTTTG
CAGCGTTATACGCAAGAGCCTTATCTGGCGGCGGGTAAATTGCAATGGCGTCCTGGGCCGCAACAGTCACTGGATGCGAC
GGTGATCGCCAGTCTGGAACAGCCTTTTTCTGCTCAGGGGGGGACGAAAGTATTAAACGGCAATCTGGGGCGGGCGGTAA
TGAAAACCTCGGCAGTGCCACGGGAGCATCAGGTTATTGAAGGGCCAGCGCGGGTATTTGAGAGTCAGCATGATGTGGAA
GCCGCCTTTGAATCCGGTGATTTGGATCGCGATTGTGTGGTGGTGGTGCGTTATCAGGGGCCGCAGGCCATTGGTATGCC
GGAGTTACATAAGCTGATGCCGCCGCTAGGAGTATTACTTGATCGTGGCTTTAAGGTAGCGTTGGTGACGGATGGCCGAT
TATCCGGCGCATCAGGCAAGGTGCCGTCTGCCATTCACGTGACGCCAGAAGCCTATTGCGGTGGTTTACTGGCCAACGTC
CGCAATGGTGACCGGATTCGGGTTGATGGGGTCAGTGGCGAGCTGTCATTACTGGTGGATGAGGCTGAATTGGCCACTCG
CGATAGTCCGTTACCGGCTATCTCTGCTTTCCATGTGGGATGTGGCCGTGAGTTGTTTGGGGCATTACGTGAACAGCTTT
CTGGTGCAGAGCAGGGGGCGTGTTGTATTCGTTTCTAA

Upstream 100 bases:

>100_bases
TGACCACAATTTACTGTTACAGGTACTGGCCGACTTTGTCGGCCTGCCCACTGGCAGCATTGAACTTTTGACCCCATTAA
CCCCATTGAGCGCATAAGGA

Downstream 100 bases:

>100_bases
ATGCTATTTAGGTAGTTTTATTCAGAGCACTGTGCGCCATTTCCGCGCAGGATTTCAATATATGAATGAGTTTCAAGTCA
ATAAATAAAAACGCAGATTT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MEMNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDML
SAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIV
PGLLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMG
LHLPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATG
GSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGL
QRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVE
AAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANV
RNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Sequences:

>Translated_625_residues
MEMNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDML
SAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIV
PGLLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMG
LHLPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATG
GSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGL
QRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVE
AAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANV
RNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
>Mature_625_residues
MEMNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDML
SAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIV
PGLLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMG
LHLPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATG
GSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGL
QRYTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVE
AAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANV
RNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=623, Percent_Identity=75.7624398073836, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=555, Percent_Identity=30.990990990991, Blast_Score=199, Evalue=6e-52,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=29.0794979079498, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=26.5799256505576, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=495, Percent_Identity=31.7171717171717, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66658; Mature: 66658

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHH
ALKNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQG
HHHHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
QDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPA
CCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMG
CCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
LHLPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCH
GQLVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYP
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCC
NGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGP
CCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCC
QQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVE
CCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHH
AAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGK
HHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCC
VPSAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVG
CCCEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCC
CGRELFGALREQLSGAEQGACCIRF
CCHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MEMNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHH
ALKNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQG
HHHHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
QDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPA
CCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMG
CCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
LHLPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCH
GQLVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYP
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCC
NGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGP
CCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCC
QQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVE
CCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHH
AAFESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGK
HHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCC
VPSAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVG
CCCEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCC
CGRELFGALREQLSGAEQGACCIRF
CCHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]