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The map label for this gene is pyrC [H]

Identifier: 218928723

GI number: 218928723

Start: 1809600

End: 1810646

Strand: Reverse

Name: pyrC [H]

Synonym: YPO1587

Alternate gene names: 218928723

Gene position: 1810646-1809600 (Counterclockwise)

Preceding gene: 218928725

Following gene: 218928722

Centisome position: 38.91

GC content: 49.57

Gene sequence:

>1047_bases
ATGACTGCACAACCCCAAACCCTAAAAATTCGCCGCCCGGATGACTGGCACATTCATCTACGTGATGATGAAATGCTCAG
TACCGTGTTGCCCTATACCTCCGAAGTATTCGCCCGCGCTATTGTTATGCCAAATCTAGCCCAGCCAATTACAACGGTTG
CCAGTGCTATTGCTTATCGGGAGCGTATTTTAGCAGCGGTTCCTGCGGGCCATAAATTCACCCCGTTGATGACGTGTTAC
CTGACTAATAGCCTTGATGCTAAAGAGTTGACCACGGGTTTTGAGCAAGGCGTTTTTACCGCGGCCAAACTGTATCCGGC
CAATGCCACCACCAACTCCACTCACGGTGTATCTGACATCCCGGCAATTTACCCGTTGTTTGAACAAATGCAAAAGATAG
GCATGCCCCTGCTTATTCACGGTGAGGTAACAGATGCGGCCGTTGACATCTTTGATCGTGAAGCCCGTTTTATTGACCAA
ATTTTAGAGCCCATTCGCCAAAAGTTTCCCGAACTAAAAATTGTCTTTGAGCATATCACGACCAAAGATGCGGCAGATTA
TGTGCTGGCAGGCAATCGTTTCCTTGGGGCAACCGTCACGCCACAACACTTGATGTTTAACCGCAATCACATGCTGGTAG
GCGGTATTCGCCCCCACTTGTTCTGCCTGCCAATATTGAAGCGCAGCACCCATCAGCAAGCATTGCGCGCAGCCGTCGCC
AGTGGTTCTGATCGCTTCTTCCTTGGGACCGATTCAGCTCCCCATGCCAAACATCGTAAAGAGTCATCTTGCGGCTGTGC
GGGTGTATTCAACGCCCCAGCGGCATTGCCTGCTTATGCTTCCGTGTTTGAGGAACTGAATGCATTGCAACATCTGGAAG
CGTTTTGCGCCTTAAATGGCCCACGATTTTATGGCTTGCCTGTTAATGATGACGTTGTTGAATTGGTTCGCACTCCATTC
CTGCAGCCAGAAGAGATCCCATTAGGCAATGAATCGGTTATTCCTTTCCTTGCGGGTCAAACGCTTAATTGGTCAGTGAA
ACGCTAA

Upstream 100 bases:

>100_bases
TGCATCCTAAGCACTTTCCGCATATCCTTAGACCCCGCCGGAAACATTCCTGTCACAACATAAAAACCCGATATCTCATC
ATGACTGCGGAGCCTGTAGA

Downstream 100 bases:

>100_bases
CTCATCAAGATTACAGCAAGCGGGCGCATCACTGGCTTTGTTCAGTGGTGCGTACAACGGCAACCTAAACATCAAAATAA
GGCGAGAGGTAGTGACAACT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYRERILAAVPAGHKFTPLMTCY
LTNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDIPAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQ
ILEPIRQKFPELKIVFEHITTKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVA
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNGPRFYGLPVNDDVVELVRTPF
LQPEEIPLGNESVIPFLAGQTLNWSVKR

Sequences:

>Translated_348_residues
MTAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYRERILAAVPAGHKFTPLMTCY
LTNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDIPAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQ
ILEPIRQKFPELKIVFEHITTKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVA
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNGPRFYGLPVNDDVVELVRTPF
LQPEEIPLGNESVIPFLAGQTLNWSVKR
>Mature_347_residues
TAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYRERILAAVPAGHKFTPLMTCYL
TNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDIPAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQI
LEPIRQKFPELKIVFEHITTKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVAS
GSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNGPRFYGLPVNDDVVELVRTPFL
QPEEIPLGNESVIPFLAGQTLNWSVKR

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=348, Percent_Identity=72.4137931034483, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=34.2696629213483, Blast_Score=170, Evalue=3e-43,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38543; Mature: 38412

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYR
CCCCCCEEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ERILAAVPAGHKFTPLMTCYLTNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDI
HHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEHEEECCCCCCCCCCCCCCC
PAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQILEPIRQKFPELKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHH
TKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVA
CCCCCCEEEECCEEECCCCCHHHHEECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHH
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNG
CCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PRFYGLPVNDDVVELVRTPFLQPEEIPLGNESVIPFLAGQTLNWSVKR
CEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCEEECC
>Mature Secondary Structure 
TAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYR
CCCCCEEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ERILAAVPAGHKFTPLMTCYLTNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDI
HHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEHEEECCCCCCCCCCCCCCC
PAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQILEPIRQKFPELKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHH
TKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVA
CCCCCCEEEECCEEECCCCCHHHHEECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHH
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNG
CCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PRFYGLPVNDDVVELVRTPFLQPEEIPLGNESVIPFLAGQTLNWSVKR
CEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA