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The map label for this gene is moeA [H]

Identifier: 218928636

GI number: 218928636

Start: 1696082

End: 1697356

Strand: Reverse

Name: moeA [H]

Synonym: YPO1495

Alternate gene names: 218928636

Gene position: 1697356-1696082 (Counterclockwise)

Preceding gene: 218928637

Following gene: 218928635

Centisome position: 36.47

GC content: 49.96

Gene sequence:

>1275_bases
ATGGATCACTGTAATACCTCGGATTTACTCTCTCTGGAACAAGCACTGACCAAAATGCTATCACAGGCCACACCATTGCC
AGCAACAGAGGTCATCCCATTGTCTGAGGCTGCGGGCCGCATCACCGCCAGCGCCATTACTTCACCTATTGCTGTCCCAC
CTTTCGCCAACTCAGCGATGGACGGCTATGCGGTACGTTGGCATGAATTGAGCGACGAGATACCCTTACCCGTCGCAGGA
GTAGCGTTTGCAGGTGCGCCGTTTAAAGATGTGTGGCCGGAAAAGACCTGCATTCGCATTATGACAGGTGCGCCACTCCC
CAAGGGTGCAGATGCCGTTGTCATGCAAGAGCACGCTGTCGTGAGTGAACAAGGTGTCATCTTCAATAGTAACATTCGAA
TCGGGCAAAACATTCGGCTGGCGGGTGAAGATATCCAGCAAGGAGCGTCAGTTTTTCCGGCTGGCGTTAAATTAGGTGCA
GCACAGCTACCGCTATTAGCCTCGTTAGGTATTGCTGAAATCGCGGTTTATCGTGCATTAAAAGTGGCTATTTTCTCAAC
CGGTGATGAATTACAGCCTATCGGACATCCCTTAGCTGAAGGACAGATTTACGATACTAACCGCTTTGCCGTCAGGCTAA
TGTTGCAGCAATTGGGGTGTCAAATCATCGATCTTGGTGTTATCCGTGACGATCAACATGCACTACGTGCAGCATTTCAG
CAGGCGGATACTGCAGCAGACTTGGTCATCAGCAGTGGGGGCGTTTCAGTCGGTGAAGCCGATTATACCAAACAGATACT
GGACGAACTCGGGGATATTGGTTTTTGGAAATTAGCCATAAAGCCCGGTAAACCTTTTGCTTTTGGTAAACTTAGCAATG
CTTGGTTCTGCGGTTTGCCAGGGAATCCTGTCTCTGCGGCCCTAACATTCTATCAACTGGTACAACCGCTGTTGGCAAAG
CTGTCCGGGCATACAGAATGGCATCCACCACTGCGATTAAAAGCCAAAGCGACAACACCACTGAAAAAAACACCAGGCCG
CTTGGACTTTCAACGTGGGGTTTTTTCCAGCAATGCGGACGGTCAGTTAGAGGTTCGCACGACTGGCCACCAAGGCTCCC
ACATTTTCAGTTCATTCAGTCAAGGCAACTGTTTTATCGTGCTTGAACGGGAACGCGGTTCGGTAGCCGTGGGGGAATCC
GTAGAAATAGAGTTGTTTAATGAATTGTTAGGAGGTAATCGACCGTTTGCCATTCATCACCCTGTCGGAGGTTGA

Upstream 100 bases:

>100_bases
CCTCAGGCAATCTCTGCCATAATGGCCTTCTTATTTTAATTGATAGCTCTGCCCCGTGACTCTCCTTTAACCGCGGCGCA
CCCAGACCTCGGAGTTCAGC

Downstream 100 bases:

>100_bases
TATGTTGCCGGAACTTTCAGATGTTGAGGCCCTGCGCTATAACCGGCAAATCACATTACGCGGTTTTGATTTTGACGGCC
AAGAGAAACTGAAAGCGGCC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADAVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGASVFPAGVKLGA
AQLPLLASLGIAEIAVYRALKVAIFSTGDELQPIGHPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGVFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG

Sequences:

>Translated_424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADAVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGASVFPAGVKLGA
AQLPLLASLGIAEIAVYRALKVAIFSTGDELQPIGHPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGVFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG
>Mature_424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADAVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGASVFPAGVKLGA
AQLPLLASLGIAEIAVYRALKVAIFSTGDELQPIGHPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGVFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=34.5088161209068, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=34.5088161209068, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787049, Length=407, Percent_Identity=68.0589680589681, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25147659, Length=356, Percent_Identity=30.8988764044944, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=318, Percent_Identity=25.1572327044025, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=377, Percent_Identity=29.7082228116711, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638841, Length=377, Percent_Identity=29.7082228116711, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45251; Mature: 45251

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCCCCCCCCCCC
DGYAVRWHELSDEIPLPVAGVAFAGAPFKDVWPEKTCIRIMTGAPLPKGADAVVMQEHAV
CCCEEEEEECCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHHE
VSEQGVIFNSNIRIGQNIRLAGEDIQQGASVFPAGVKLGAAQLPLLASLGIAEIAVYRAL
ECCCCEEEECCEEECCEEEECCHHHHCCCCCCCCCCCCCCHHCCHHHHCCHHHHHHHHHH
KVAIFSTGDELQPIGHPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
EEEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHH
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLP
HCCCHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGVFSSNAD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGESVEIELFNELLGGNRPFAIHH
CEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCEEEEC
PVGG
CCCC
>Mature Secondary Structure
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCCCCCCCCCCC
DGYAVRWHELSDEIPLPVAGVAFAGAPFKDVWPEKTCIRIMTGAPLPKGADAVVMQEHAV
CCCEEEEEECCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHHE
VSEQGVIFNSNIRIGQNIRLAGEDIQQGASVFPAGVKLGAAQLPLLASLGIAEIAVYRAL
ECCCCEEEECCEEECCEEEECCHHHHCCCCCCCCCCCCCCHHCCHHHHCCHHHHHHHHHH
KVAIFSTGDELQPIGHPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
EEEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHH
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLP
HCCCHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGVFSSNAD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGESVEIELFNELLGGNRPFAIHH
CEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCEEEEC
PVGG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]