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The map label for this gene is ompA

Identifier: 218928581

GI number: 218928581

Start: 1627192

End: 1628253

Strand: Reverse

Name: ompA

Synonym: YPO1435

Alternate gene names: 218928581

Gene position: 1628253-1627192 (Counterclockwise)

Preceding gene: 218928582

Following gene: 218928580

Centisome position: 34.99

GC content: 50.19

Gene sequence:

>1062_bases
ATGAAAAAGACAGCTATCGCATTAGCAGTGGCACTGGTAGGTTTCGCTACAGTAGCGCAAGCCGCACCAAAAGATAACAC
CTGGTACACCGGTGGTAAATTGGGTTGGTCTCAGTATCAAGATACTGGTTCTATCATCAATAACGATGGTCCAACTCATA
AAGATCAGCTGGGTGCCGGTGCGTTCTTCGGTTACCAAGCAAATCAGTACCTGGGCTTTGAGATGGGATACGACTGGCTT
GGTCGTATGCCTTACAAAGGCGACATCAATAATGGCGCTTTCAAGGCTCAAGGCGTTCAGTTAGCAGCTAAACTGAGCTA
CCCAGTAGCACAAGACCTTGACGTATATACCCGTCTGGGTGGTTTAGTATGGCGTGCAGATGCTAAAGGCTCCTTCGATG
GTGGTCTTGACCGTGCTAGCGGCCATGATACCGGTGTTTCTCCATTGGTAGCTCTGGGTGCTGAATACGCATGGACCAAA
AACTGGGCAACCCGTATGGAATACCAGTGGGTTAACAACATCGGCGACCGTGAAACCGTTGGTGCTCGTCCAGACAACGG
CCTCCTGAGTGTTGGTGTTTCTTACCGCTTTGGTCAGGAAGATGCAGCAGCGCCAATCGTTGCTCCAACACCTGCTCCAG
CGCCAATTGTTGACACTAAGCGTTTCACATTAAAATCTGATGTGCTGTTTGGTTTCAACAAAGCAAACCTGAAGCCAGAA
GGCCAGCAAGCTCTGGACCAACTGTACGCACAACTGAGCTCTATCGATCCTAAAGATGGTTCTGTAGTTGTTCTGGGCTT
TGCTGACCGTATCGGTCAACCAGCGCCTAACTTAGCTCTGTCTCAGCGTCGTGCTGACAGCGTGCGTGACTACCTGGTTT
CTAAAGGTATCCCTGCTGACAAAATCACTGCTCGCGGTGAAGGTCAAGCAAACCCAGTTACAGGCAACACCTGTGACAAC
GTGAAACCACGTGCTGCTCTGATTGAGTGCCTGGCACCAGATCGTCGCGTAGAGATCGAAGTGAAAGGCTACAAAGAAGT
TGTGACTCAGCCACAGGCTTAA

Upstream 100 bases:

>100_bases
CAACGTAATTAACGGGAGCGTAAAAACCTTGGCGAAGAATTTTAACCAAGGGCTTAGCTTTTAAAGCTCATTGCCTATTT
GGATGATAATGAGGCGTAAA

Downstream 100 bases:

>100_bases
GTTAACTTCTTTCGTGAAAAACCCCGCGCTATGCGGGGTTTTTTTTGTGCCCAGAAAACCCCCAGCTAGGCTGGGGGTTC
AGTAAAGCTTTCAGCTTTGG

Product: outer membrane protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAGAFFGYQANQYLGFEMGYDWL
GRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLGGLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTK
NWATRMEYQWVNNIGDRETVGARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPE
GQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPADKITARGEGQANPVTGNTCDN
VKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA

Sequences:

>Translated_353_residues
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAGAFFGYQANQYLGFEMGYDWL
GRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLGGLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTK
NWATRMEYQWVNNIGDRETVGARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPE
GQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPADKITARGEGQANPVTGNTCDN
VKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA
>Mature_353_residues
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAGAFFGYQANQYLGFEMGYDWL
GRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLGGLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTK
NWATRMEYQWVNNIGDRETVGARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPE
GQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPADKITARGEGQANPVTGNTCDN
VKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA

Specific function: Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes

COG id: COG2885

COG function: function code M; Outer membrane protein and related peptidoglycan-associated (lipo)proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 OmpA-like domain

Homologues:

Organism=Escherichia coli, GI1787191, Length=353, Percent_Identity=73.371104815864, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI48994946, Length=120, Percent_Identity=35, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Mi

Swissprot (AC and ID): OMPA_YERPE (Q8ZG77)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0175
- RefSeq:   NP_670036.1
- RefSeq:   NP_992692.1
- RefSeq:   YP_002346456.1
- ProteinModelPortal:   Q8ZG77
- GeneID:   1147682
- GeneID:   1174275
- GeneID:   2765622
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1435
- KEGG:   ypk:y2735
- KEGG:   ypm:YP_1326
- HOGENOM:   HBG741096
- OMA:   ATRRISY
- ProtClustDB:   PRK10808
- BioCyc:   YPES187410:Y2735-MONOMER
- BioCyc:   YPES214092:YPO1435-MONOMER
- GO:   GO:0000746
- InterPro:   IPR011250
- InterPro:   IPR006664
- InterPro:   IPR002368
- InterPro:   IPR006690
- InterPro:   IPR000498
- InterPro:   IPR006665
- Gene3D:   G3DSA:2.40.160.20
- Gene3D:   G3DSA:3.30.1330.60
- PRINTS:   PR01021
- PRINTS:   PR01022

Pfam domain/function: PF00691 OmpA; PF01389 OmpA_membrane; SSF103088 OmpA/MotB_C

EC number: NA

Molecular weight: Translated: 37930; Mature: 37930

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS01068 OMPA_1; PS51123 OMPA_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x48d8ad64)-; HASH(0xb9a5fa0)-; HASH(0x48e51094)-; HASH(0x48e634fc)-; HASH(0xd64332c)-; HASH(0x48f26130)-; HASH(0x48f35628)-; HASH(0xc711180)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAG
CCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCEECCCCCCCHHHCCCC
AFFGYQANQYLGFEMGYDWLGRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLG
EEECCCCCCEEEHCCCHHHHCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHC
GLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTKNWATRMEYQWVNNIGDRETV
CEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHCCCCCCCC
GARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPE
CCCCCCCEEEECEEEEECCCCCCCCEEECCCCCCCCCCCCCEEEECCEEEECCCCCCCCC
GQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPAD
HHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
KITARGEGQANPVTGNTCDNVKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA
HEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCH
>Mature Secondary Structure
MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAG
CCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCEECCCCCCCHHHCCCC
AFFGYQANQYLGFEMGYDWLGRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLG
EEECCCCCCEEEHCCCHHHHCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHC
GLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTKNWATRMEYQWVNNIGDRETV
CEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHCCCCCCCC
GARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPE
CCCCCCCEEEECEEEEECCCCCCCCEEECCCCCCCCCCCCCEEEECCEEEECCCCCCCCC
GQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPAD
HHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
KITARGEGQANPVTGNTCDNVKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA
HEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430