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The map label for this gene is bioC [H]

Identifier: 218928317

GI number: 218928317

Start: 1299245

End: 1300048

Strand: Direct

Name: bioC [H]

Synonym: YPO1153

Alternate gene names: 218928317

Gene position: 1299245-1300048 (Clockwise)

Preceding gene: 218928316

Following gene: 218928318

Centisome position: 27.92

GC content: 53.86

Gene sequence:

>804_bases
ATGGCCTCTGTCACTGAGCACGCGCAATGGGGCGTTGGGTGTTTACCGCCACTGAACGTTGATAAACAGGCGATTGCGGC
TGCATTCAGCCGGGCCGCCGAGAGCTACGACAGCGCGGCTAATTTACAGCGAGAAACGGGTCATCGGTTAGTGCAGTTGG
GCCAGCAGCATACGGGTTTTGTGGTGTTGGATGCGGGTTGTGGCACGGGGCATTTCAGCCAGCATTGGCGCTTGTTGGGT
AAGCGGGTCATTGCCTTGGATCTGGCGGCAGGTATGTTGGATTATGCGCGCCAACAGCAGGTCGCTGACGACTATCTGCT
GGGGGATATTGAACATATTCCACTGCCTGATCAGTCGGTGGATATCTGCTTTAGCAATTTGGCGGTGCAATGGTGTTCAG
ATCTGGGGGCGGCATTGAGTGAATTCTACCGAGTGACGCGCCCCGGCGGGATCATCCTATTTTCTACCTTGGCAGAAGGC
TCCCTTGATGAATTAGGGCAAGCGTGGCAACAGGTGGATGGTCAGCGTCATGTAAATGATTTTTTGCCATTGCAACATAT
CCAGACGGCCTGCCAATATTATCGCCATCACCTAACAACCGCGTTATATCAGCCACGGTTTCCTAACGTGATAGCGCTGA
TGCGCTCGTTACAAGGCATTGGTGCCACGCACTTGCATCATGGGCGTCAGGCTGGGTTACAGGGGCGTCAACGTCTGGCG
GCGCTACAACGGGCCTATGTCATGCAATCTGGCGGCTATCCACTGAGTTATCATATGGTTTATGGGGTTATCTATCGTGA
CTAA

Upstream 100 bases:

>100_bases
ATCCGCCCCCCCACGGTGCCACCAGGAAGCGCCAGATTGCGCATTACCCTCAGCGCGGCTCACCAACCCGAGGATATCGA
TAGATTATTGGAGGTGCTTT

Downstream 100 bases:

>100_bases
ACGTTGGTTTATCACCGGTACCGATACTGATGTCGGTAAAACCGTCGCCAGTTGTGCATTACTGCAAGCGGCCACCGCTC
AGGGGTACCGTACTGCTGGC

Product: biotin synthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MASVTEHAQWGVGCLPPLNVDKQAIAAAFSRAAESYDSAANLQRETGHRLVQLGQQHTGFVVLDAGCGTGHFSQHWRLLG
KRVIALDLAAGMLDYARQQQVADDYLLGDIEHIPLPDQSVDICFSNLAVQWCSDLGAALSEFYRVTRPGGIILFSTLAEG
SLDELGQAWQQVDGQRHVNDFLPLQHIQTACQYYRHHLTTALYQPRFPNVIALMRSLQGIGATHLHHGRQAGLQGRQRLA
ALQRAYVMQSGGYPLSYHMVYGVIYRD

Sequences:

>Translated_267_residues
MASVTEHAQWGVGCLPPLNVDKQAIAAAFSRAAESYDSAANLQRETGHRLVQLGQQHTGFVVLDAGCGTGHFSQHWRLLG
KRVIALDLAAGMLDYARQQQVADDYLLGDIEHIPLPDQSVDICFSNLAVQWCSDLGAALSEFYRVTRPGGIILFSTLAEG
SLDELGQAWQQVDGQRHVNDFLPLQHIQTACQYYRHHLTTALYQPRFPNVIALMRSLQGIGATHLHHGRQAGLQGRQRLA
ALQRAYVMQSGGYPLSYHMVYGVIYRD
>Mature_266_residues
ASVTEHAQWGVGCLPPLNVDKQAIAAAFSRAAESYDSAANLQRETGHRLVQLGQQHTGFVVLDAGCGTGHFSQHWRLLGK
RVIALDLAAGMLDYARQQQVADDYLLGDIEHIPLPDQSVDICFSNLAVQWCSDLGAALSEFYRVTRPGGIILFSTLAEGS
LDELGQAWQQVDGQRHVNDFLPLQHIQTACQYYRHHLTTALYQPRFPNVIALMRSLQGIGATHLHHGRQAGLQGRQRLAA
LQRAYVMQSGGYPLSYHMVYGVIYRD

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=222, Percent_Identity=25.2252252252252, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786994, Length=251, Percent_Identity=49.402390438247, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29577; Mature: 29446

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCEEEEHHEEEEECC
>Mature Secondary Structure 
ASVTEHAQWGVGCLPPLNVDKQAIAAAFSRAAESYDSAANLQRETGHRLVQLGQQHTGF
CCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VVLDAGCGTGHFSQHWRLLGKRVIALDLAAGMLDYARQQQVADDYLLGDIEHIPLPDQSV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
DICFSNLAVQWCSDLGAALSEFYRVTRPGGIILFSTLAEGSLDELGQAWQQVDGQRHVND
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHH
FLPLQHIQTACQYYRHHLTTALYQPRFPNVIALMRSLQGIGATHLHHGRQAGLQGRQRLA
HCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHH
ALQRAYVMQSGGYPLSYHMVYGVIYRD
HHHHHHHHHCCCCCEEEEHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]