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The map label for this gene is tktA [H]

Identifier: 218928099

GI number: 218928099

Start: 1016330

End: 1018324

Strand: Reverse

Name: tktA [H]

Synonym: YPO0926

Alternate gene names: 218928099

Gene position: 1018324-1016330 (Counterclockwise)

Preceding gene: 218928101

Following gene: 218928098

Centisome position: 21.88

GC content: 52.03

Gene sequence:

>1995_bases
ATGTCCTCTCGTAAAGAGCTTGCCAACGCTATCCGCGCACTAAGCATGGATGCCGTGCAAAAAGCGAAGTCCGGCCATCC
CGGAGCCCCGATGGGTATGGCAGATATTGCCGAAGTCCTGTGGCGTGATTATCTGAACCATAATCCAACTAACCCACACT
GGGCTGATCGTGACCGTTTCGTCCTGTCAAATGGTCACGGCTCCATGTTGATTTATAGCCTGTTGCATCTCACAGGTTAT
GACCTGCCGATGGAAGAGCTAAAAAATTTCCGCCAACTGCACTCTAAAACGCCTGGCCACCCTGAATATGGTTATACCGC
TGGTGTAGAAACCACCACTGGGCCATTGGGGCAAGGCATTGCCAATGCTGTTGGTTTTGCTATCGCAGAACGCACGCTGG
GGGCGCAGTTTAACCGCCCAGGTCACGACATTGTCGATCACCATACCTACGCCTTTATGGGCGATGGTTGCATGATGGAA
GGGATCTCTCACGAGGTTTGCTCTCTGGCCGGTACGATGAAGCTGGGCAAACTGACGGCTTTCTATGATGACAACGGTAT
TTCTATCGATGGTCATGTTGAAGGCTGGTTCACTGATGACACGGCGGCCCGTTTCGAAGCCTACGGCTGGCATGTGGTAC
GGGGTGTTGATGGCCATAACGCGGACTCTATTAAAGCAGCTATCGAAGAAGCACATAAGGTTACCGACAAGCCTTCATTG
TTGATGTGCAAAACGATTATTGGTTTTGGCTCACCAAACAAAGCTGGAACCCATGATTCCCATGGTGCGCCATTAGGTGA
AGCGGAAGTGGCAGCAACCCGTGAAGCATTAGGTTGGAAATACCCGGCATTTGAAATCCCACAAGATATCTATGCGGCAT
GGGATGCCAAAGAAGCGGGCAAAGCCAAAGAAGCGGCCTGGAACGAGAAGTTCGCTGCGTATGCCAAGGCTTATCCAGAA
CTGGCGGCTGAATTCAAACGTCGTGTCAGCGGTGAATTACCGGCTAACTGGGCCGTTGAATCCAAGAAATTCATCGAACA
ATTGCAAGCCAATCCAGCAAATATTGCCAGCCGCAAAGCCTCACAAAATGCGCTGGAAGCCTTCGGTAAAGTGTTACCTG
AGTTCCTGGGCGGTTCTGCTGACCTGGCACCGAGTAACCTGACTATCTGGTCTGGCTCTAAATCCTTGAGCGACGATCTG
GCTGGTAACTACATTCACTACGGTGTCCGTGAATTTGGTATGTCTGCCATCATGAACGGTATTGCCCTGCACGGCGGTTT
CATCCCTTACGGCGCAACCTTCCTGATGTTTGTGGAATATGCCCGTAACGCAGTGCGCATGGCGGCACTGATGAAAATCC
GTAGCGTGTTCGTTTATACCCATGACTCTATTGGTCTGGGCGAAGATGGCCCAACCCATCAGCCTGTTGAACAGATGGCC
AGCCTGCGTGTTACCCCGAATATGAGTACCTGGCGTCCTTGTGATCAGGTCGAATCTGCAGTGGCATGGCAGTATGCGCT
GGAACGTAAAGATGGCCCAAGCGCACTGATCTTCTCCCGACAGAATCTGGCACAGCAGCCACGTACTGCGGAGCAGCTAG
CCAATATCGCCAAAGGCGGGTATGTGCTGAAGGATTGTGCAGGCCAGCCTGAACTGATCCTGATTGCTACCGGCTCTGAA
GTGGAGTTAGCAGTTGCTGCGGCTGATCAACTGACGGCCACTGGCCGTAAAGTCCGCGTTGTCTCTATGCCATCAACTGA
TGCATTCGATAAACAAGATGCGGCTTACCGTGAGTCAGTATTGCCATCTGCGGTTAGCGCACGTGTTGCCGTAGAAGCGG
GTATTGCGGATTATTGGTACAAATACGTTGGCCTGAATGGCGCGGTTGTCGGTATGACCACGTTTGGTGAATCAGCGCCA
GCTGAATTGCTGTTCAAAGAGTTTGGTTTCACCGTGGAAAACGTGGTGGCGAAAGCTCAGGCGCTGCTGAAGTAA

Upstream 100 bases:

>100_bases
TGCAACTCGAATTATTTAGAGTATAGTGATTGCCGTTTCAATGCTGAGTCTGAGAAAATGGTAATCTTGAACGCTTTGTT
AATCCGACCTGGAGTAAAAC

Downstream 100 bases:

>100_bases
TTAACGGTTAAGAAGCGATTAGTCCCTAAAGAGCGATTAGCCGTTAAAAAGTCATTAACTGTTAAAACAGGCAACGACGT
TATCAATACTGCAAATGGGT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMEELKNFRQLHSKTPGHPEYGYTAGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTMKLGKLTAFYDDNGISIDGHVEGWFTDDTAARFEAYGWHVVRGVDGHNADSIKAAIEEAHKVTDKPSL
LMCKTIIGFGSPNKAGTHDSHGAPLGEAEVAATREALGWKYPAFEIPQDIYAAWDAKEAGKAKEAAWNEKFAAYAKAYPE
LAAEFKRRVSGELPANWAVESKKFIEQLQANPANIASRKASQNALEAFGKVLPEFLGGSADLAPSNLTIWSGSKSLSDDL
AGNYIHYGVREFGMSAIMNGIALHGGFIPYGATFLMFVEYARNAVRMAALMKIRSVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYALERKDGPSALIFSRQNLAQQPRTAEQLANIAKGGYVLKDCAGQPELILIATGSE
VELAVAAADQLTATGRKVRVVSMPSTDAFDKQDAAYRESVLPSAVSARVAVEAGIADYWYKYVGLNGAVVGMTTFGESAP
AELLFKEFGFTVENVVAKAQALLK

Sequences:

>Translated_664_residues
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMEELKNFRQLHSKTPGHPEYGYTAGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTMKLGKLTAFYDDNGISIDGHVEGWFTDDTAARFEAYGWHVVRGVDGHNADSIKAAIEEAHKVTDKPSL
LMCKTIIGFGSPNKAGTHDSHGAPLGEAEVAATREALGWKYPAFEIPQDIYAAWDAKEAGKAKEAAWNEKFAAYAKAYPE
LAAEFKRRVSGELPANWAVESKKFIEQLQANPANIASRKASQNALEAFGKVLPEFLGGSADLAPSNLTIWSGSKSLSDDL
AGNYIHYGVREFGMSAIMNGIALHGGFIPYGATFLMFVEYARNAVRMAALMKIRSVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYALERKDGPSALIFSRQNLAQQPRTAEQLANIAKGGYVLKDCAGQPELILIATGSE
VELAVAAADQLTATGRKVRVVSMPSTDAFDKQDAAYRESVLPSAVSARVAVEAGIADYWYKYVGLNGAVVGMTTFGESAP
AELLFKEFGFTVENVVAKAQALLK
>Mature_663_residues
SSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGYD
LPMEELKNFRQLHSKTPGHPEYGYTAGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEG
ISHEVCSLAGTMKLGKLTAFYDDNGISIDGHVEGWFTDDTAARFEAYGWHVVRGVDGHNADSIKAAIEEAHKVTDKPSLL
MCKTIIGFGSPNKAGTHDSHGAPLGEAEVAATREALGWKYPAFEIPQDIYAAWDAKEAGKAKEAAWNEKFAAYAKAYPEL
AAEFKRRVSGELPANWAVESKKFIEQLQANPANIASRKASQNALEAFGKVLPEFLGGSADLAPSNLTIWSGSKSLSDDLA
GNYIHYGVREFGMSAIMNGIALHGGFIPYGATFLMFVEYARNAVRMAALMKIRSVFVYTHDSIGLGEDGPTHQPVEQMAS
LRVTPNMSTWRPCDQVESAVAWQYALERKDGPSALIFSRQNLAQQPRTAEQLANIAKGGYVLKDCAGQPELILIATGSEV
ELAVAAADQLTATGRKVRVVSMPSTDAFDKQDAAYRESVLPSAVSARVAVEAGIADYWYKYVGLNGAVVGMTTFGESAPA
ELLFKEFGFTVENVVAKAQALLK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=689, Percent_Identity=26.4150943396226, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI4507521, Length=689, Percent_Identity=26.4150943396226, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI133778974, Length=689, Percent_Identity=24.6734397677794, Blast_Score=138, Evalue=2e-32,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=86.2745098039216, Blast_Score=1213, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=74.2813918305598, Blast_Score=1054, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=24.7774480712166, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=49.478390461997, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=45.5089820359281, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=687, Percent_Identity=26.783114992722, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45550715, Length=687, Percent_Identity=26.783114992722, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24666278, Length=679, Percent_Identity=24.4477172312224, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645119, Length=653, Percent_Identity=26.0336906584992, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71874; Mature: 71743

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEYGYTAGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTMKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHHHCCEEE
FYDDNGISIDGHVEGWFTDDTAARFEAYGWHVVRGVDGHNADSIKAAIEEAHKVTDKPSL
EECCCCEEECCCCCCEECCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCH
LMCKTIIGFGSPNKAGTHDSHGAPLGEAEVAATREALGWKYPAFEIPQDIYAAWDAKEAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHCC
KAKEAAWNEKFAAYAKAYPELAAEFKRRVSGELPANWAVESKKFIEQLQANPANIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNALEAFGKVLPEFLGGSADLAPSNLTIWSGSKSLSDDLAGNYIHYGVREFGMSAIMNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
IALHGGFIPYGATFLMFVEYARNAVRMAALMKIRSVFVYTHDSIGLGEDGPTHQPVEQMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYALERKDGPSALIFSRQNLAQQPRTAEQLANIAKGG
HEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCHHHHHHHHHCCC
YVLKDCAGQPELILIATGSEVELAVAAADQLTATGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEECCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
LPSAVSARVAVEAGIADYWYKYVGLNGAVVGMTTFGESAPAELLFKEFGFTVENVVAKAQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC
>Mature Secondary Structure 
SSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEYGYTAGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTMKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHHHCCEEE
FYDDNGISIDGHVEGWFTDDTAARFEAYGWHVVRGVDGHNADSIKAAIEEAHKVTDKPSL
EECCCCEEECCCCCCEECCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCH
LMCKTIIGFGSPNKAGTHDSHGAPLGEAEVAATREALGWKYPAFEIPQDIYAAWDAKEAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHCC
KAKEAAWNEKFAAYAKAYPELAAEFKRRVSGELPANWAVESKKFIEQLQANPANIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNALEAFGKVLPEFLGGSADLAPSNLTIWSGSKSLSDDLAGNYIHYGVREFGMSAIMNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
IALHGGFIPYGATFLMFVEYARNAVRMAALMKIRSVFVYTHDSIGLGEDGPTHQPVEQMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYALERKDGPSALIFSRQNLAQQPRTAEQLANIAKGG
HEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCHHHHHHHHHCCC
YVLKDCAGQPELILIATGSEVELAVAAADQLTATGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEECCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
LPSAVSARVAVEAGIADYWYKYVGLNGAVVGMTTFGESAPAELLFKEFGFTVENVVAKAQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]