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The map label for this gene is mscS [H]

Identifier: 218928092

GI number: 218928092

Start: 1008476

End: 1009345

Strand: Reverse

Name: mscS [H]

Synonym: YPO0919

Alternate gene names: 218928092

Gene position: 1009345-1008476 (Counterclockwise)

Preceding gene: 218928093

Following gene: 218928091

Centisome position: 21.69

GC content: 50.11

Gene sequence:

>870_bases
ATGGAAGAACTAAACGTAGTTGAAGGGATCAATAATGCAAGCACCTGGTTGGCGAATAACCAGGACTTACTGATCCAATA
CGCAGTCAATATTATTGCCGCGTTATTGATCCTGATTGTCGGTTCGATCATCGCTAAAGTGCTATCTGGCATGCTCAATC
GGGTGATGAGATTGCGTGGCATTGATGTCACCGTTGCCGACTTCTTATCAGCGATGGTGCGTTACAGCATTCTGGCTTTC
ACCATTGTGGCGGTACTGGGGCGGCTGGGTGTACAAACCGCATCGGTCATTGCGGTCATTGGTGCTGCGGGTTTGGCCGT
TGGTTTAGCCCTACAAGGGTCGCTGTCTAACTTTGCTGCTGGTGTGTTGCTGGTCGCCTTCCGTCCGTTTAAAGCGGGTG
AGTACGTCGATCTGGGCGGTGTGGCCGGGACGGTGGTGCAGGTGCAGATTTTCTCAACCACCCTACGTACGGTTGATGAC
AAAATCATTGTGGTACCAAATGGCAAAATTATTGCCAACAATATTATTAATACCAGCCGCGAGCCGAACCGCCGTACCGA
CATGATTGTCGGTGTGGCATATGATGCCGATATTGATGTGGTGAAAAAGGTTCTTGGTGACATCATCGCAGCTGATAGTC
GGATCATACACGAGAAAGGGGTGACGGTGCGCTTGAATGAAATGGCACCGTCCTCACTGAATTTTGCTGTTCGTGTTTGG
ACGACCAATGGTGATGCGCAAGAGGTGTTTTGGGACTTGACTGAAAACTTCAAGCGGGCGCTGGATGCGCACAAAATTGG
TATCCCTTACCCACAAATGGATGTGCATTTGCATCAGGTGGCAAAAGCCGAAGCCGAGAAGCCGGAGTAA

Upstream 100 bases:

>100_bases
ACCCTACTACATAGGCCGTTGGCTAGAGTCGCCAGCGTTAGATGGTGATTTTTTTTGGCGTAATTGCTCCTGTAGGGAGC
TTTTTTGTAGGATGGTTTAA

Downstream 100 bases:

>100_bases
GGTTTTTCACCGTGGTAAGCGGTAAATAGATTAAACGGGCCTCAGTGCCCGTTTTTACTCGCTCGGTTATTTGACTCGCT
CTGCTGTTTTATCAGTTCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MEELNVVEGINNASTWLANNQDLLIQYAVNIIAALLILIVGSIIAKVLSGMLNRVMRLRGIDVTVADFLSAMVRYSILAF
TIVAVLGRLGVQTASVIAVIGAAGLAVGLALQGSLSNFAAGVLLVAFRPFKAGEYVDLGGVAGTVVQVQIFSTTLRTVDD
KIIVVPNGKIIANNIINTSREPNRRTDMIVGVAYDADIDVVKKVLGDIIAADSRIIHEKGVTVRLNEMAPSSLNFAVRVW
TTNGDAQEVFWDLTENFKRALDAHKIGIPYPQMDVHLHQVAKAEAEKPE

Sequences:

>Translated_289_residues
MEELNVVEGINNASTWLANNQDLLIQYAVNIIAALLILIVGSIIAKVLSGMLNRVMRLRGIDVTVADFLSAMVRYSILAF
TIVAVLGRLGVQTASVIAVIGAAGLAVGLALQGSLSNFAAGVLLVAFRPFKAGEYVDLGGVAGTVVQVQIFSTTLRTVDD
KIIVVPNGKIIANNIINTSREPNRRTDMIVGVAYDADIDVVKKVLGDIIAADSRIIHEKGVTVRLNEMAPSSLNFAVRVW
TTNGDAQEVFWDLTENFKRALDAHKIGIPYPQMDVHLHQVAKAEAEKPE
>Mature_289_residues
MEELNVVEGINNASTWLANNQDLLIQYAVNIIAALLILIVGSIIAKVLSGMLNRVMRLRGIDVTVADFLSAMVRYSILAF
TIVAVLGRLGVQTASVIAVIGAAGLAVGLALQGSLSNFAAGVLLVAFRPFKAGEYVDLGGVAGTVVQVQIFSTTLRTVDD
KIIVVPNGKIIANNIINTSREPNRRTDMIVGVAYDADIDVVKKVLGDIIAADSRIIHEKGVTVRLNEMAPSSLNFAVRVW
TTNGDAQEVFWDLTENFKRALDAHKIGIPYPQMDVHLHQVAKAEAEKPE

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=285, Percent_Identity=66.6666666666667, Blast_Score=386, Evalue=1e-109,
Organism=Escherichia coli, GI1786670, Length=258, Percent_Identity=27.1317829457364, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787591, Length=263, Percent_Identity=23.574144486692, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367355, Length=254, Percent_Identity=20.8661417322835, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 31112; Mature: 31112

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELNVVEGINNASTWLANNQDLLIQYAVNIIAALLILIVGSIIAKVLSGMLNRVMRLRG
CCCCCHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDVTVADFLSAMVRYSILAFTIVAVLGRLGVQTASVIAVIGAAGLAVGLALQGSLSNFAA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVAFRPFKAGEYVDLGGVAGTVVQVQIFSTTLRTVDDKIIVVPNGKIIANNIINTSR
HHHHHEECCCCCCCEEECCCCCCEEEEEEEHHHHHHHCCCEEEEEECCEEEECCCCCCCC
EPNRRTDMIVGVAYDADIDVVKKVLGDIIAADSRIIHEKGVTVRLNEMAPSSLNFAVRVW
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCCEEEEEE
TTNGDAQEVFWDLTENFKRALDAHKIGIPYPQMDVHLHQVAKAEAEKPE
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEELNVVEGINNASTWLANNQDLLIQYAVNIIAALLILIVGSIIAKVLSGMLNRVMRLRG
CCCCCHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDVTVADFLSAMVRYSILAFTIVAVLGRLGVQTASVIAVIGAAGLAVGLALQGSLSNFAA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVAFRPFKAGEYVDLGGVAGTVVQVQIFSTTLRTVDDKIIVVPNGKIIANNIINTSR
HHHHHEECCCCCCCEEECCCCCCEEEEEEEHHHHHHHCCCEEEEEECCEEEECCCCCCCC
EPNRRTDMIVGVAYDADIDVVKKVLGDIIAADSRIIHEKGVTVRLNEMAPSSLNFAVRVW
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCCEEEEEE
TTNGDAQEVFWDLTENFKRALDAHKIGIPYPQMDVHLHQVAKAEAEKPE
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]