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The map label for this gene is gcvT [H]

Identifier: 218928080

GI number: 218928080

Start: 994834

End: 995931

Strand: Reverse

Name: gcvT [H]

Synonym: YPO0907

Alternate gene names: 218928080

Gene position: 995931-994834 (Counterclockwise)

Preceding gene: 218928081

Following gene: 218928079

Centisome position: 21.4

GC content: 50.55

Gene sequence:

>1098_bases
ATGGCTAAGCAGACCCCGCTGTATGACCAACATGTCGCGTGCGGTGCGCGTATGGTAGATTTTCATGGTTGGATGATGCC
ATTGCATTATGGCTCCCAAATTGACGAACACCATTTTGTGCGGCAGGACGCAGGCATGTTTGATGTCTCCCACATGACCA
TCGTTGATTTGCACGGTAACCGTACCCGTGAGTTTTTGCGCTATCTGTTGGCTAACGATGTAGCCAAACTGACCCAACCG
GGCAAAGCCCTTTACACCGGGATGCTGAATGAATCCGGCGGTGTTATCGATGATTTGATTGTTTACTTCCTCAGCGAAGA
TTATTTCCGTTTAGTGGTTAACTCCGCCACCCGTGATAAAGACCTCGCTTGGATAAGTCAGCATGCTGAACCTTATCAGG
TCGAGGTCACGGTGCGTGACGATCTGGCACTGATTGCAGTACAAGGCCCACAAGCCCAACAAAAAGTTGCCACGTTACTG
ACCACCGAGCAGCAACAGGCTATTGCGGGCATGAAGCCATTCTTTGGTATTCAAACCGGCGATTTATTTATTGCTACCAC
GGGTTATACCGGTGAAGCCGGGTATGAAATTGCGTTGCCGAAACAGCAGGTTGTTGCGTTCTGGCAGCAACTATTGGCCG
CCGGTGTGAAGCCCGCAGGTCTTGGTGCGCGTGATACGCTGCGCTTAGAAGCGGGGATGAACTTATATGGTCAGGAAATG
GATGAAAAAACGTCTCCGTTAGCCGCTAATATGGGGTGGACAGTGGCCTGGCAACCAGAAGATCGTCAGTTTATTGGTCG
TGCTGCGTTGGAAAGGCAGCGAATGAAGGGGACTGAGCAATTGGTTGGTCTGATCATGACGGAAAAAGGCGTGTTACGTA
ATGAATTGCCGGTGTATTTTTTTGATGCCGCAGGCAATCAGCATGTTGGGGTGATAACCAGCGGTTCATTTTCGCCAACA
CTGGGTTTCAGTATTGCGCTAGCCCGTGTACCCGCAGGTATCGGTGAACATGCTGTGGTACAAATCCGTAACCGTGAAAT
GCCGGTACGGGTAACAAAACCCGGTTTTGTGCGAGCGGGCAAAGCCATCGTATTGTAA

Upstream 100 bases:

>100_bases
AAAAGGTATCGTTTGCGTCGTGGTGTCCCTACCTGTTTATTGTGGTCTTGAAGCAGGTACCCTGCGGCTTCAAACACGAA
GTGTATATTGAGGGAAAAAG

Downstream 100 bases:

>100_bases
GTTTGTTTTCCATTATTCTGAATTATAAGAGCCTTCTCTTTTGGCTCTATCTCTTTTAAGGAATAGCAATGAGTAATGTA
CCAACAGAATTGAAATATGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MAKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGNRTREFLRYLLANDVAKLTQP
GKALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDKDLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLL
TTEQQQAIAGMKPFFGIQTGDLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEM
DEKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYFFDAAGNQHVGVITSGSFSPT
LGFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAGKAIVL

Sequences:

>Translated_365_residues
MAKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGNRTREFLRYLLANDVAKLTQP
GKALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDKDLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLL
TTEQQQAIAGMKPFFGIQTGDLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEM
DEKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYFFDAAGNQHVGVITSGSFSPT
LGFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAGKAIVL
>Mature_364_residues
AKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGNRTREFLRYLLANDVAKLTQPG
KALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDKDLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLLT
TEQQQAIAGMKPFFGIQTGDLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEMD
EKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYFFDAAGNQHVGVITSGSFSPTL
GFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAGKAIVL

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=373, Percent_Identity=33.7801608579088, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI257796258, Length=345, Percent_Identity=34.4927536231884, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=30.1630434782609, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=31.6455696202532, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI24797151, Length=360, Percent_Identity=28.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI197927446, Length=369, Percent_Identity=25.7452574525745, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21361378, Length=369, Percent_Identity=25.7452574525745, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194306651, Length=379, Percent_Identity=24.5382585751979, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=79.6143250688705, Blast_Score=620, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=34.5744680851064, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71994045, Length=339, Percent_Identity=23.8938053097345, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=339, Percent_Identity=23.8938053097345, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32563613, Length=342, Percent_Identity=23.3918128654971, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=376, Percent_Identity=35.3723404255319, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=33.9522546419098, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI28571104, Length=271, Percent_Identity=28.7822878228782, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20130091, Length=421, Percent_Identity=23.2779097387173, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40323; Mature: 40192

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGN
CCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCCCHHHHHHHCCCEEEECEEEEEEECCC
RTREFLRYLLANDVAKLTQPGKALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDK
HHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
DLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLLTTEQQQAIAGMKPFFGIQTG
HHHHHHCCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHCHHHHHHHCCCCCCCEECC
DLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHCHH
DEKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYF
CCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCEEE
FDAAGNQHVGVITSGSFSPTLGFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAG
EECCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCEECC
KAIVL
CEEEC
>Mature Secondary Structure 
AKQTPLYDQHVACGARMVDFHGWMMPLHYGSQIDEHHFVRQDAGMFDVSHMTIVDLHGN
CCCCCCCHHHHHCCCEEEECCCEEEEECCCCCCCHHHHHHHCCCEEEECEEEEEEECCC
RTREFLRYLLANDVAKLTQPGKALYTGMLNESGGVIDDLIVYFLSEDYFRLVVNSATRDK
HHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
DLAWISQHAEPYQVEVTVRDDLALIAVQGPQAQQKVATLLTTEQQQAIAGMKPFFGIQTG
HHHHHHCCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHCHHHHHHHCCCCCCCEECC
DLFIATTGYTGEAGYEIALPKQQVVAFWQQLLAAGVKPAGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHCHH
DEKTSPLAANMGWTVAWQPEDRQFIGRAALERQRMKGTEQLVGLIMTEKGVLRNELPVYF
CCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCEEE
FDAAGNQHVGVITSGSFSPTLGFSIALARVPAGIGEHAVVQIRNREMPVRVTKPGFVRAG
EECCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCEECC
KAIVL
CEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA