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The map label for this gene is parE [H]

Identifier: 218927861

GI number: 218927861

Start: 727036

End: 728931

Strand: Direct

Name: parE [H]

Synonym: YPO0668

Alternate gene names: 218927861

Gene position: 727036-728931 (Clockwise)

Preceding gene: 218927860

Following gene: 218927862

Centisome position: 15.62

GC content: 50.95

Gene sequence:

>1896_bases
ATGACTGAATCCAGCTATAACGCTGATGCCATTGAAGTACTCAGCGGTCTAGAACCAGTGCGCCGTCGTCCAGGAATGTA
TACGGACACCTCGCGGCCAAACCACCTCGGTCAAGAGGTGATTGATAACAGCGTCGATGAGGCGCTGGCTGGTCATGCCC
GTCGTATTGACGTCATTTTACACGCCGATCAATCACTCGAAGTGATTGATGATGGCCGTGGGATGCCGGTTGATATCCAC
CCAGAGGAGGGGGTTCCTGCTGTTGAACTGATTTTATGTCGGTTACATGCGGGCGGTAAATTCTCCAATAAGAACTATCA
GTTTTCTGGTGGTTTGCACGGTGTGGGTATTTCAGTTGTTAACGCCTTATCCAAGCGGGTAGAAGTCACGGTACGCCGTG
ATAGTCAAATCTACAGTATCGCTTTTGAAAATGGCGATAAAGTCCAGGATTTACAGGTTATTGGGACGTGCGGTAAGCGC
AATACTGGCACCAGTGTGCATTTCTGGCCGGACGTCTCTTTCTTTGATAGCCCGCGTTTTTCGGTTTCTCGTCTATCCCA
TTTACTGAAAGCCAAAGCGGTATTGTGTCCAGGCGTCGAGATCGTTTTTAAAGATCAGGTCAACAACACAGAACAGCGTT
GGTGTTATGCCGATGGTCTAACCGATTATCTGATGGAAGCGGTTAACGGCTTTATTACTCTGCCAGAAGCACCCTTTGTG
GGGTCTTTTGCCGGTGATACAGAAGCTATCGACTGGGCATTACTGTGGTTGCCAGAAGGCGGCGAACTGCTGACTGAAAG
CTACGTTAACCTGATCCCAACCATGCAGGGTGGTACCCACGTTAATGGCTTGCGTCAGGGGTTGCTGGATGCCATGCGCG
ATTTCTGTGAATACCGCAATATCTTGCCTCGCGGAGTCAAGCTCTCGGCAGATGATATCTGGGAACGCTGTGCTTATGTG
TTATCGGTAAAAATGCAGGATCCACAGTTCGCGGGTCAGACGAAAGAGCGGCTCTCCTCACGTCAATGTGCGGCCTTTGT
CTCCGGTGTTGTCAAAGATGCCTTCAGCTTATGGTTAAACCAGAATGTGCAGGCCGCAGAACAACTGGCTGAACTGGCGA
TTTCCAGCGCTCAGCGTCGTATGCGTGCAGCAAAAAAAGTGGTGCGTAAAAAACTGACCAGTGGCCCGGCACTGCCTGGC
AAACTGGCAGATTGTACTTCGCAGGACTTGAGCCTCACAGAGCTATTTTTGGTGGAAGGGGATTCCGCCGGCGGTTCCGC
GAAACAAGCCCGCGACCGGGAATATCAGGCGATCATGCCGTTGAAAGGCAAGATCTTGAACACTTGGGAGGTCTCCTCTG
ATGAAGTCCTGGCCTCGCAGGAAGTTCACGATATTTCCGTGGCGATCGGTATTGATCCTGATAGCGAAGACTTAAGCCAG
TTACGTTACGGTAAAGTGTGCATTCTGGCGGATGCGGACTCCGATGGCCTGCATATTGCCACGTTGCTGTGCGCACTGTT
TGTGCGTCACTTCCGGGCACTGGTCCGTAATGGTCATGTGTATGTGGCGATGCCGCCGTTGTACCGTATCGATCTAGGCA
AAGAGGTCTTTTACGCGCTGGATGAAGAAGAGAAAGCCGGTGTGCTTGAGCAACTGAAACGCAAACGGGGTAAACCTAAC
GTTCAGCGTTTCAAAGGGTTGGGTGAAATGAACCCATTACAATTGCGTGAAACCACCCTTGATCCCAATACCCGCCGTCT
GGTGCAATTGACCATCAGTGATGATGATATTGATCACACTCTGGCCGTTATGGATATGTTGTTGGCAAAGAAACGCTCGG
AAGATCGCCGCAACTGGCTACAAGAGAAAGGGGATACTGCTGAGATCGAGGTCTGA

Upstream 100 bases:

>100_bases
ATTAGGCGGTGTAAGCGCGACCTAATGACTCCGGGGCCGGATGGTCAATGGGGTATGTCACCGCCAGCCTTCCAACCATT
AGCCGAATATTAATCAAACC

Downstream 100 bases:

>100_bases
TCGATGAAAGTCACGTTGGAAGAGTTGCAGGCATTTACCTCGGTAGTGGACTGCGGCTCTATCACGGCTGCGGCAGAGCA
GCGCAGCCAAACGACATCGG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MTESSYNADAIEVLSGLEPVRRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHARRIDVILHADQSLEVIDDGRGMPVDIH
PEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDSQIYSIAFENGDKVQDLQVIGTCGKR
NTGTSVHFWPDVSFFDSPRFSVSRLSHLLKAKAVLCPGVEIVFKDQVNNTEQRWCYADGLTDYLMEAVNGFITLPEAPFV
GSFAGDTEAIDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMRDFCEYRNILPRGVKLSADDIWERCAYV
LSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAELAISSAQRRMRAAKKVVRKKLTSGPALPG
KLADCTSQDLSLTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
LRYGKVCILADADSDGLHIATLLCALFVRHFRALVRNGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKRGKPN
VQRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDDDIDHTLAVMDMLLAKKRSEDRRNWLQEKGDTAEIEV

Sequences:

>Translated_631_residues
MTESSYNADAIEVLSGLEPVRRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHARRIDVILHADQSLEVIDDGRGMPVDIH
PEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDSQIYSIAFENGDKVQDLQVIGTCGKR
NTGTSVHFWPDVSFFDSPRFSVSRLSHLLKAKAVLCPGVEIVFKDQVNNTEQRWCYADGLTDYLMEAVNGFITLPEAPFV
GSFAGDTEAIDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMRDFCEYRNILPRGVKLSADDIWERCAYV
LSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAELAISSAQRRMRAAKKVVRKKLTSGPALPG
KLADCTSQDLSLTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
LRYGKVCILADADSDGLHIATLLCALFVRHFRALVRNGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKRGKPN
VQRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDDDIDHTLAVMDMLLAKKRSEDRRNWLQEKGDTAEIEV
>Mature_630_residues
TESSYNADAIEVLSGLEPVRRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHARRIDVILHADQSLEVIDDGRGMPVDIHP
EEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDSQIYSIAFENGDKVQDLQVIGTCGKRN
TGTSVHFWPDVSFFDSPRFSVSRLSHLLKAKAVLCPGVEIVFKDQVNNTEQRWCYADGLTDYLMEAVNGFITLPEAPFVG
SFAGDTEAIDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMRDFCEYRNILPRGVKLSADDIWERCAYVL
SVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAELAISSAQRRMRAAKKVVRKKLTSGPALPGK
LADCTSQDLSLTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQL
RYGKVCILADADSDGLHIATLLCALFVRHFRALVRNGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKRGKPNV
QRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDDDIDHTLAVMDMLLAKKRSEDRRNWLQEKGDTAEIEV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=583, Percent_Identity=25.557461406518, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI19913406, Length=586, Percent_Identity=23.3788395904437, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1789408, Length=631, Percent_Identity=90.9667194928685, Blast_Score=1207, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=553, Percent_Identity=40.8679927667269, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=605, Percent_Identity=24.1322314049587, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17535065, Length=639, Percent_Identity=24.4131455399061, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI212645657, Length=251, Percent_Identity=26.2948207171315, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=700, Percent_Identity=24.1428571428571, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17136538, Length=583, Percent_Identity=24.0137221269297, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69995; Mature: 69864

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESSYNADAIEVLSGLEPVRRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHARRIDVIL
CCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
HADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVV
ECCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHH
NALSKRVEVTVRRDSQIYSIAFENGDKVQDLQVIGTCGKRNTGTSVHFWPDVSFFDSPRF
HHHHHHEEEEEECCCEEEEEEECCCCCEEHHHEEECCCCCCCCCEEEEECCCCCCCCCCH
SVSRLSHLLKAKAVLCPGVEIVFKDQVNNTEQRWCYADGLTDYLMEAVNGFITLPEAPFV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHEEECCCHHHHHHHHHCCEEECCCCCCC
GSFAGDTEAIDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMRDFCEYRN
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILPRGVKLSADDIWERCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLN
CCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNVQAAEQLAELAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTSQDLSLTELFLVEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEEEEC
DSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
CCCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHCCCCEEEEEEEECCCCHHHHHH
LRYGKVCILADADSDGLHIATLLCALFVRHFRALVRNGHVYVAMPPLYRIDLGKEVFYAL
HCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHEEE
DEEEKAGVLEQLKRKRGKPNVQRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDDDIDHT
CCHHHCCHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHH
LAVMDMLLAKKRSEDRRNWLQEKGDTAEIEV
HHHHHHHHHHHCCHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
TESSYNADAIEVLSGLEPVRRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHARRIDVIL
CCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
HADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVV
ECCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHH
NALSKRVEVTVRRDSQIYSIAFENGDKVQDLQVIGTCGKRNTGTSVHFWPDVSFFDSPRF
HHHHHHEEEEEECCCEEEEEEECCCCCEEHHHEEECCCCCCCCCEEEEECCCCCCCCCCH
SVSRLSHLLKAKAVLCPGVEIVFKDQVNNTEQRWCYADGLTDYLMEAVNGFITLPEAPFV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHEEECCCHHHHHHHHHCCEEECCCCCCC
GSFAGDTEAIDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMRDFCEYRN
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILPRGVKLSADDIWERCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLN
CCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNVQAAEQLAELAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTSQDLSLTELFLVEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEEEEC
DSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
CCCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHCCCCEEEEEEEECCCCHHHHHH
LRYGKVCILADADSDGLHIATLLCALFVRHFRALVRNGHVYVAMPPLYRIDLGKEVFYAL
HCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHEEE
DEEEKAGVLEQLKRKRGKPNVQRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDDDIDHT
CCHHHCCHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHH
LAVMDMLLAKKRSEDRRNWLQEKGDTAEIEV
HHHHHHHHHHHCCHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]