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The map label for this gene is murC [H]

Identifier: 218927752

GI number: 218927752

Start: 601301

End: 602776

Strand: Direct

Name: murC [H]

Synonym: YPO0556

Alternate gene names: 218927752

Gene position: 601301-602776 (Clockwise)

Preceding gene: 218927751

Following gene: 218927753

Centisome position: 12.92

GC content: 51.96

Gene sequence:

>1476_bases
GTGAATACACAACAACTGGCGAAACTGCGTACTATCGTGCCCGAGATGCGACGTGTCCGGCACATTCACTTTGTTGGCAT
CGGTGGTGCCGGCATGGGGGGTATCGCCGAAGTGTTGGCCAACGAAGGTTATCAGATTAGTGGTTCAGATTTAGCACCCA
ACTCGGTAACTCAGCATTTGACTGCCCTGGGTGCACAGATTTATTTCCATCATCGCCCGGAAAACGTGCTGGATGCGAGC
GTGGTCGTGGTTTCTACTGCAATCTCTGCGGATAACCCAGAGATTGTCGCGGCCCGTGAGGCGAGAATACCGGTGATCCG
CCGCGCAGAAATGTTGGCGGAATTGATGCGCTATCGCCATGGGATTGCCGTTGCTGGCACCCACGGCAAAACCACCACAA
CGGCGATGTTATCCAGTATTTATGCCGAAGCAGGGTTAGATCCAACGTTCGTCAATGGTGGGTTAGTCAAGGCCGCGGGT
ACACATGCTCGTTTGGGTTCCAGCCGTTACCTGATTGCAGAAGCCGATGAAAGCGACGCGTCATTCCTGCATTTGCAACC
GATGGTGGCGATTGTTACCAATATCGAAGCCGATCATATGGATACCTACCAAGGCGACTTCGAAAATTTAAAACAGACAT
TCATTAACTTTTTGCACAATTTGCCCTTTTATGGCCGTGCGGTGATGTGTATCGATGATCCCGTAGTGCGTGAATTATTG
CCACGTGTTGGCCGTCACATCACAACCTATGGTTTCAGTGATGATGCTGATGTGCAGATCGCCAGCTATCGGCAAGAAGG
CCCACAAGGGCACTTCACGTTGCGCCGTCAGGATAAACCGTTGATAGAGGTGACCTTGAATGCACCAGGTCGCCACAATG
CACTGAATGCGGCGGCAGCAGTCGCTGTCGCAACAGAAGAAGGCATTGAAGACGAAGATATCCTGCGTGCATTAGTGGGT
TTCCAAGGGACGGGGCGCCGTTTTGATTTCCTCGGCAACTTCCCACTGGCCCCGGTTAACGGTAAAGAAGGCAGTGCGAT
GCTGGTTGATGATTATGGTCATCACCCTACCGAAGTGGATGCCACCATTAAAGCCGCACGTGCTGGTTGGCCGGATAAAC
GCATTGTCATGCTCTTTCAGCCACACCGCTATACCCGAACCCGCGATCTGTATGACGATTTCGCGAATGTGCTGTCACAG
GTCGATGTTTTATTGATGCTGGATGTGTATGCCGCAGGTGAGCCACCGATCCCAGGGGCAGATAGCCGCGCGTTGTGCCG
AACGATTCGTAATCGCGGTAAGTTGGACCCTATTTTAGTGCCAGACAGCGAATCAGCACCTGAAATGTTGGCGCAAATAC
TGAACGGGGAAGACCTGATCTTGGTTCAGGGCGCAGGTAACATTGGTAAAATTGCCCGTAAATTGGCTGAGCATAAATTG
CAGCCACAGTTAAAAGACGAGGAACATCATGGCTGA

Upstream 100 bases:

>100_bases
GTTACGGTTTTGAAATAGCGATGACCTTGAAATAAACAGTGATCAGTGGGCGATGAATGCAGGCTGTGAATACATGACAG
ACAAAAAAGTGAAGAGAAAC

Downstream 100 bases:

>100_bases
GAAAGTCGCGGTATTGCTGGGTGGGACCTCTGCGGAGCGTGAAGTGTCATTACTGTCAGGTCAGGCGGTATTGGCAGGCT
TGAAAGAAGCCGGTATCGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHHRPENVLDAS
VVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCIDDPVVRELL
PRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVG
FQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIARKLAEHKL
QPQLKDEEHHG

Sequences:

>Translated_491_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHHRPENVLDAS
VVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCIDDPVVRELL
PRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVG
FQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIARKLAEHKL
QPQLKDEEHHG
>Mature_491_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHHRPENVLDAS
VVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCIDDPVVRELL
PRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVG
FQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIARKLAEHKL
QPQLKDEEHHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=86.3265306122449, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.2916666666667, Blast_Score=138, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53655; Mature: 53655

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHH
TALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRH
HHHHHEEEEEECCCCHHHHEEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHCCCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCIDDPVVRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHH
VAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIPGA
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIARKLAEHKL
CHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCC
QPQLKDEEHHG
CCCCCCCCCCC
>Mature Secondary Structure
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHH
TALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRH
HHHHHEEEEEECCCCHHHHEEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHCCCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCIDDPVVRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHH
VAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIPGA
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIARKLAEHKL
CHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCC
QPQLKDEEHHG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA